Biochemical Actions of Hormones, Volume VII is a nine-chapter text that covers a broad range of subjects representing research efforts on hormone action. This book deals first with the developments on hormones of the thymus and the evidence on the regulation of liver steroid and drug metabolism by the hypothalamus and anterior pituitary. These topics are followed by discussions on the regulation by neurotransmitters in the hypothalamus of LHRH and somatostatin; the hormonal regulation of protein degradation in liver and in isolated cells; and the hormonal regulation of lipid mobilization from adipose tissue. Considerable chapters are devoted to steroid hormone mechanisms and the cell genetics of glucocorticoid responsiveness. The remaining chapters explore the mero-receptor and androgenic regulation in male accessory tissue. These chapters also highlight the molecular biological aspects of thyroid hormone action. This volume is an ideal source for biologists, biochemists, and researchers working in the subject and in related fields.

Comparative Biochemistry: A Comprehensive Treatise, Volume VII: Supplementary Volume focuses on the processes, methodologies, and approaches involved in molecular biochemistry. The selection first offers information on expressions of the pentose phosphate cycle, including description, criteria for the presence of the pentose phosphate cycle, chordates, segmented worms, mollusks, echinoderms, roundworms, flatworms, algae, and higher plants. The text then ponders on chitin and mucosubstances, as well as the distribution and biochemistry of chitin, molecular structure and function of chitin, and chitin in relation to mucosubstances. The publication reviews the cellular aspects of active transport and hormones and behavior. Topics include relations between inorganic ions, sugar, amino acids, fatty acids, and bioelectric potentials; aspects of the regulation of the intracellular pool of free amino acids; hormones and permeability characteristics of living cellular membranes; and chemical nature of the structure responsible for the permeability characteristics of living membranes. The recording and measurement of behavior, role of hormones in the patterning of behavior, and hormones influencing behavior and the behavior most subject to hormonal influence and control are also discussed. The selection is a dependable source of data for readers interested in the processes, methodologies, approaches involved in biochemistry.

This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.

Biochemical Actions of Hormones, Volume III is a collection of papers that deals with steroid hormone action, hypothalamic-regulating hormones, plasma membrane receptors, thyroid hormones, hormones acting on the synthesis of proteins in liver perfusion systems, as well as on approaches using genetics and cell culture. One paper explains why cell hybridization can be a useful technique in studying both genetic control of differentiated functions and of hormonal induction. Another paper discusses the general approaches in the study of ligand-membrane interactions, and cites experiments dealing with polypeptide hormones and catecholamines. It explains in detail the physiochemical interaction between a radioactively labeled ligand and the plasma membrane, either as found in an intact cell or in an isolated membrane preparation. One paper discusses the introduction and time course of estrogen-stimulated biosynthetic events in the uterus. It analyzes the relationship of the estrogen-binding protein to the biological responses of the uterus, including the "domino" versus "sustained output" model of estrogen action. One paper explains, by using a chick oviduct, how to investigate the hypothesis that hormones can activate genes to allow transcription of new species of messenger RNA. This collection can prove beneficial to biochemists, molecular biologists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in cell research.

This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and longer use of hormone therapy. The malignancy finally forms castration-resistant prostate cancer (CRPC) despite the lack of testicular androgen. With advances in understanding of the molecular basis of hormone dependence and CRPC, many new androgen receptor-targeted agents have emerged. During the last decade, much evidence on hormone therapy has been accumulated in Japan. Interestingly, some of these findings are different from those reported from Western countries, suggesting ethnic variation in the outcome of hormone therapy. In the chapters of this book, expert authors provide exhaustive interpretations of the evidence recently reported from Japan and provide important Asian perspectives on hormone therapy for PCa. This work benefits not only Asian urologists but also their Western counterparts and all physicians and medical personnel who are involved in the treatment of PCa.

An Insider's Perspective of Prostate Cancer: Understanding Effects, Management Options and Consequences provides scientifically based information on the management and treatment of prostate cancer. The text is designed to be neither prescriptive nor proscriptive, providing succinct, yet comprehensive details in 'bite size chunks' for ready assimilation and application. Sections cover recent approaches the prostate cancer landscape has made by providing background statistical and anatomical information that is followed by relevant genetic, immunological and background data. The book then proceeds to explain the mechanisms involved with cancer development and the spread and metastases that can occur in a minority of those diagnosed. In addition to acknowledging the importance of psychological effects of diagnosis and management interventions, the undervalued benefits of exercise are also emphasized, including information on holistic management. This comprehensive approach makes this a perfect reference for up-to-date information on all aspects of prostate cancer and its management. - Provides succinct, yet comprehensive coverage on the management and treatment of prostate cancer and subsequent consequences for patients - Reviews how prostate cancers change and how treatments can adapt - Delivers guidance on how to assess information with ranking in terms of levels of evidence, thus enabling the evaluation of critical reports and claims made in relation to prostate cancer and other conditions