This book, written by two mathematicians from the University of Southern California, provides a broad introduction to the important subject of nonlinear mixture models from a Bayesian perspective. It contains background material, a brief description of Markov chain theory, as well as novel algorithms and their applications. It is self-contained and unified in presentation, which makes it ideal for use as an advanced textbook by graduate students and as a reference for independent researchers. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary background material needed to go further into the subject and explore the research literature.In this book the authors present Bayesian methods of analysis for nonlinear, hierarchical mixture models, with a finite, but possibly unknown, number of components. These methods are then applied to various problems including population pharmacokinetics and gene expression analysis. In population pharmacokinetics, the nonlinear mixture model, based on previous clinical data, becomes the prior distribution for individual therapy. For gene expression data, one application included in the book is to determine which genes should be associated with the same component of the mixture (also known as a clustering problem). The book also contains examples of computer programs written in BUGS. This is the first book of its kind to cover many of the topics in this field.

Wiley Series in Probability and Statistics A modern perspective on mixed models The availability of powerful computing methods in recent decades has thrust linear and nonlinear mixed models into the mainstream of statistical application. This volume offers a modern perspective on generalized, linear, and mixed models, presenting a unified and accessible treatment of the newest statistical methods for analyzing correlated, nonnormally distributed data. As a follow-up to Searle's classic, Linear Models, and Variance Components by Searle, Casella, and McCulloch, this new work progresses from the basic one-way classification to generalized linear mixed models. A variety of statistical methods are explained and illustrated, with an emphasis on maximum likelihood and restricted maximum likelihood. An invaluable resource for applied statisticians and industrial practitioners, as well as students interested in the latest results, Generalized, Linear, and Mixed Models features: * A review of the basics of linear models and linear mixed models * Descriptions of models for nonnormal data, including generalized linear and nonlinear models * Analysis and illustration of techniques for a variety of real data sets * Information on the accommodation of longitudinal data using these models * Coverage of the prediction of realized values of random effects * A discussion of the impact of computing issues on mixed models

Bei der Regressionsanalyse von Datenmaterial erhält man leider selten lineare oder andere einfache Zusammenhänge (parametrische Modelle). Dieses Buch hilft Ihnen, auch komplexere, nichtparametrische Modelle zu verstehen und zu beherrschen. Stärken und Schwächen jedes einzelnen Modells werden durch die Anwendung auf Standarddatensätze demonstriert. Verbreitete nichtparametrische Modelle werden mit Hilfe von Bayes-Verfahren in einen kohärenten wahrscheinlichkeitstheoretischen Zusammenhang gebracht.

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

With Bayesian statistics rapidly becoming accepted as a way to solve applied statisticalproblems, the need for a comprehensive, up-to-date source on the latest advances in thisfield has arisen.Presenting the basic theory of a large variety of linear models from a Bayesian viewpoint,Bayesian Analysis of Linear Models fills this need. Plus, this definitive volume containssomething traditional-a review of Bayesian techniques and methods of estimation, hypothesis,testing, and forecasting as applied to the standard populations ... somethinginnovative-a new approach to mixed models and models not generally studied by statisticianssuch as linear dynamic systems and changing parameter models ... and somethingpractical-clear graphs, eary-to-understand examples, end-of-chapter problems, numerousreferences, and a distribution appendix.Comprehensible, unique, and in-depth, Bayesian Analysis of Linear Models is the definitivemonograph for statisticians, econometricians, and engineers. In addition, this text isideal for students in graduate-level courses such as linear models, econometrics, andBayesian inference.

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

Incorporating new and updated information, this second edition of THE bestselling text in Bayesian data analysis continues to emphasize practice over theory, describing how to conceptualize, perform, and critique statistical analyses from a Bayesian perspective. Its world-class authors provide guidance on all aspects of Bayesian data analysis and include examples of real statistical analyses, based on their own research, that demonstrate how to solve complicated problems. Changes in the new edition include: Stronger focus on MCMC Revision of the computational advice in Part III New chapters on nonlinear models and decision analysis Several additional applied examples from the authors' recent research Additional chapters on current models for Bayesian data analysis such as nonlinear models, generalized linear mixed models, and more Reorganization of chapters 6 and 7 on model checking and data collection Bayesian computation is currently at a stage where there are many reasonable ways to compute any given posterior distribution. However, the best approach is not always clear ahead of time. Reflecting this, the new edition offers a more pluralistic presentation, giving advice on performing computations from many perspectives while making clear the importance of being aware that there are different ways to implement any given iterative simulation computation. The new approach, additional examples, and updated information make Bayesian Data Analysis an excellent introductory text and a reference that working scientists will use throughout their professional life.

In reality many time series are non-linear and non-gaussian. They show the characters like flat stretches, bursts of activity and outliers. (Bivariate) Mixture Transition Distribution model are introduced to study these time series data. EM algorithm is used for point estimations of parameters. However as is known, for many mixture models, the likelihoods couldn't be maximized since they will go to infinity. Number of mixtures should be prefixed in this way but in many realities it is unknown.

The past decade has seen powerful new computational tools for modeling which combine a Bayesian approach with recent Monte simulation techniques based on Markov chains. This book is the first to offer a systematic presentation of the Bayesian perspective of finite mixture modelling. The book is designed to show finite mixture and Markov switching models are formulated, what structures they imply on the data, their potential uses, and how they are estimated. Presenting its concepts informally without sacrificing mathematical correctness, it will serve a wide readership including statisticians as well as biologists, economists, engineers, financial and market researchers.