Focusing on issues of gene organization, regulation, and evolution in the context of the whole life of the cell, this new volume complements the editors' classic 1993 volume Bacillus subtilis and Other Gram-Positive Bacteria. Building upon the previous edition, Bacillus subtilis and Its Closest Relatives contains an updated annotation of the complete B. subtilis genome and includes a unique compilation of major pathways of metabolism and macromolecular synthesis, correlating genes and proteins and assigning new functions to many genes. It also provides clear explanations of the major regulatory mechanisms that are unique to gram-positive bacteria as well as an overview of their special properties. This essential reference offers detailed, current information and is valuable reading for microbiologists, biotechnologists, and students.

The field of microbiology has developed considerably in the last 20 years, building exponentially on its own discoveries and growing to encompass many other disciplines. Unfortunately, the literature in the field tends to be either encyclopedic in scope or presented as a textbook and oriented for the student. Finding its niche between these two pol

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.

Bacteriologists from all levels of expertise and within all specialties rely on this Manual as one of the most comprehensive and authoritative works. Since publication of the first edition of the Systematics, the field has undergone revolutionary changes, leading to a phylogenetic classification of prokaryotes based on sequencing of the small ribosomal subunit. The list of validly named species has more than doubled since publication of the first edition, and descriptions of over 2000 new and realigned species are included in this new edition along with more in-depth ecological information about individual taxa and extensive introductory essays by leading authorities in the field.

Genetics and Biotechnology of Bacilli contains the proceedings of the Second International Conference on Genetics and Biotechnology of Bacilli, held at Stanford University in Stanford, California, on July 6-8, 1983. Contributors discuss the progress that has been made concerning the genetics and biotechnology of Bacillus and focus on topics built around the themes of chromosomal organization, secretion, transcription, gene cloning, gene expression, and synthesis of sporulation-associated products. This text is organized into 33 chapters and begins with an overview of bacteriophage lambda biology, with emphasis on lambda insertion, controlled DNA rearrangements, operator-promoter function, and the evolution of extrachromosomal elements. The reader is then introduced to genetic mapping of cloned ribosomal RNA genes, gene amplification in Bacillus subtilis, beta-lactamases of Bacilli, and the role of a Bacillus secretion vector in the secretion of foreign gene products. This book also gives an account of various facets of Bacillus biology, especially in the identification of promoters, cloning of foreign genes, and selection of expressed gene products. This reference material is a valuable resource for geneticists, microbiologists, and biotechnologists, as well as students and researchers in the fields of molecular biology and biochemistry.

The study of bacterial spores spans biosecurity to ecology The first articles describing the sporulation process were published by Robert Koch and Ferdinand Cohn in the late 19th century. Although most of the work accomplished in the past 50 years has focused on the model organism Bacillus subtilis, more recent work significantly expanded the scope of sporulation research to integrate medically relevant spore pathogens, such as B. anthracis and Clostridium difficile, as well as investigations of the ecology of spore-forming species. This new direction is supported by an explosion of novel techniques that can also be applied to nonmodel organisms, such as next-generation sequencing, metagenomics, and transcriptomics. The Bacterial Spore provides a comprehensive series of reviews of the major topics in spore biology that represent intensive, cutting-edge spore research. Editors Adam Driks and Patrick Eichenberger assembled chapters written by a team of diverse and multidisciplinary experts in biodefense and microbial forensics to produce an overview of topics of spore research, such as spore molecular biology, bioremediation, systems biology, issues in biodefense, and the challenge of food safety that is accessible to any reader, regardless of expertise. The Bacterial Spore also encompasses the diversity of spore research, which will appeal to those seeking to broaden their knowledge. The Bacterial Spore is a reference for a wide range of readers, including geneticists, cell biologists, physiologists, structural and evolutionary biologists, applied scientists, advanced undergraduate and graduate students, and nonresearchers, such as national security professionals.

Bacillus anthracis causes anthrax in all mammals, including humans. Depending upon the route of entry of B. anthracis spores, infection can result in cutaneous lesions, which are readily treatable with antibiotics, or systemic lethal disease, which is nearly always fatal. The continuing worldwide incidence of anthrax in animal populations, the risk of human infection associated with animal outbreaks, and the threat of use of B. anthracis as a biological weapon warrant continued investigation of this organisms and its virulence mechanims. Furthermore, B. anthracis is an excellent model system for inverstigation of virulence gene expression by bacteria.

The Molecular Biology of the Bacilli, Volume I: Bacillus subtilis focuses on areas of research traditionally investigated in Bacillus subtilis, as well as topics in which outstanding progress has been made. It discusses the sporulation, defective bacteriophage, and transformation of Bacillus subtilis. Organized into 11 chapters, the book begins with the genetic map of Bacillus subtilis, followed by DNA replication and RNA polymerase of the said species. The book then describes the translational apparatus of Bacillus subtilis. It also explains the genetic transformation in Bacillus subtilis; the sporulation genes; the regulatory mechanisms in the development of lytic bacteriophages in this species; the temperate Bacillus subtilis phages; the specialized transduction in Bacillus subtilis; and molecular cloning in this organism. Lastly, the book considers the most economically important areas of the microbiological industry employing bacilli, including the production of enzymes, nucleosides, riboflavin, and preparations pathogenic to insects. This book will be useful to scientists who are concerned with the use of Bacillus subtilis as a tool for the study of molecular biology and to those who wish to increase the medical, veterinary, and industrial usefulness of this and related organisms.

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise knowledge and practical information about working with microorganisms. Useful to anyone interested in microbes, the book is intended to especially benefit four groups: trained microbiologists working within one specific area of microbiology; people with training in other disciplines, and use microorganisms as a tool or "chemical reagent"; business people evaluating investments in microbiology focused companies; and an emerging group, people in occupations and trades that might have limited training in microbiology, but who require specific practical information. Key Features Provides a comprehensive compendium of basic information on microorganisms—from classical microbiology to genomics. Includes coverage of disease-causing bacteria, bacterial viruses (phage), and the use of phage for treating diseases, and added coverage of extremophiles. Features comprehensive coverage of antimicrobial agents, including chapters on anti-fungals and anti-virals. Covers the Microbiome, gene editing with CRISPR, Parasites, Fungi, and Animal Viruses. Adds numerous chapters especially intended for professionals such as healthcare and industrial professionals, environmental scientists and ecologists, teachers, and businesspeople. Includes comprehensive survey table of Clinical, Commercial, and Research-Model bacteria. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. Chapter 21, "Archaea," of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license available at http://www.taylorfrancis.com See Emanuel Goldman's Open Access article: "Lamarck redux and other false arguments against SARS-CoV-2 vaccination," https://www.embopress.org/doi/full/10.15252/embr.202254675