Interventions that delay aging are expected to improve health. In the current US National Institute on Aging's Interventions Testing Program (ITP) the immunosuppressive drug rapamycin was found to increase the maximum life span in mice. These mice started receiving this treatment at an age corresponding to 60 years in humans. Rapamycin targets the same mechanism which was critically involved in the life span extension previously seen in certain mutants of worms flies and mice. The maximum life span was increased in some of these mutants by more than 250 percent, suggesting 1) that the maximum life span is limited by a common mechanism of death, and 2) that humans may possibly gain a few more decades beyond 120 years by interfering in this mechanism. As rapamycin has important adverse effects, this books looks into the underlying mechanisms and describes several natural interventions likely to decrease the rate of aging without using pharmacological drugs.

From the physician behind the wildly popular NutritionFacts website, How Not to Die reveals the groundbreaking scientific evidence behind the only diet that can prevent and reverse many of the causes of disease-related death. The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives. The simple truth is that most doctors are good at treating acute illnesses but bad at preventing chronic disease. The fifteen leading causes of death claim the lives of 1.6 million Americans annually. This doesn't have to be the case. By following Dr. Greger's advice, all of it backed up by strong scientific evidence, you will learn which foods to eat and which lifestyle changes to make to live longer. History of prostate cancer in your family? Put down that glass of milk and add flaxseed to your diet whenever you can. Have high blood pressure? Hibiscus tea can work better than a leading hypertensive drug-and without the side effects. Fighting off liver disease? Drinking coffee can reduce liver inflammation. Battling breast cancer? Consuming soy is associated with prolonged survival. Worried about heart disease (the number 1 killer in the United States)? Switch to a whole-food, plant-based diet, which has been repeatedly shown not just to prevent the disease but often stop it in its tracks. In addition to showing what to eat to help treat the top fifteen causes of death, How Not to Die includes Dr. Greger's Daily Dozen -a checklist of the twelve foods we should consume every day.Full of practical, actionable advice and surprising, cutting edge nutritional science, these doctor's orders are just what we need to live longer, healthier lives.

"This book is about dying, not about death. We are always dying a big, always giving things up, always having things taken away. Is there a person alive who isn't really curious about what dying is for them? Is there a person alive who wouldn't like to go to their dying full of excitement, without fear and without morbidity? This books tells you how." -- Front cover.

When the end of life makes its inevitable appearance, people should be able to expect reliable, humane, and effective caregiving. Yet too many dying people suffer unnecessarily. While an "overtreated" dying is feared, untreated pain or emotional abandonment are equally frightening. Approaching Death reflects a wide-ranging effort to understand what we know about care at the end of life, what we have yet to learn, and what we know but do not adequately apply. It seeks to build understanding of what constitutes good care for the dying and offers recommendations to decisionmakers that address specific barriers to achieving good care. This volume offers a profile of when, where, and how Americans die. It examines the dimensions of caring at the end of life: Determining diagnosis and prognosis and communicating these to patient and family. Establishing clinical and personal goals. Matching physical, psychological, spiritual, and practical care strategies to the patient's values and circumstances. Approaching Death considers the dying experience in hospitals, nursing homes, and other settings and the role of interdisciplinary teams and managed care. It offers perspectives on quality measurement and improvement, the role of practice guidelines, cost concerns, and legal issues such as assisted suicide. The book proposes how health professionals can become better prepared to care well for those who are dying and to understand that these are not patients for whom "nothing can be done."

The New York Times bestselling guide to the lifesaving diet that can both prevent and help reverse the effects of heart disease Based on the groundbreaking results of his twenty-year nutritional study, Prevent and Reverse Heart Disease by Dr. Caldwell Esselstyn illustrates that a plant-based, oil-free diet can not only prevent the progression of heart disease but can also reverse its effects. Dr. Esselstyn is an internationally known surgeon, researcher and former clinician at the Cleveland Clinic and a featured expert in the acclaimed documentary Forks Over Knives. Prevent and Reverse Heart Disease has helped thousands across the country, and is the book behind Bill Clinton’s life-changing vegan diet. The proof lies in the incredible outcomes for patients who have followed Dr. Esselstyn's program, including a number of patients in his original study who had been told by their cardiologists that they had less than a year to live. Within months of starting the program, all Dr. Esselstyn’s patients began to improve dramatically, and twenty years later, they remain free of symptoms. Complete with more than 150 delicious recipes perfect for a plant-based diet, the national bestseller Prevent and Reverse Heart Disease explains the science behind the simple plan that has drastically changed the lives of heart disease patients forever. It will empower readers and give them the tools to take control of their heart health.

**American Journal of Nursing (AJN) Book of the Year Awards, 1st Place in Medical-Surgical Nursing, 2023** **Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Medical/Surgical** Gain the knowledge and skills you need to succeed in medical-surgical nursing with this leading textbook! Lewis's Medical-Surgical Nursing, 12th Edition uses a conversational writing style, a focus on nursing concepts and clinical trends, evidence-based content, and basic pathophysiology review to provide the solid foundation needed in a rapidly changing healthcare environment. Comprehensive chapters cover topics including nursing management and collaboration, health promotion, acute interventions, and ambulatory care. Summary tables and boxes make it easy to find essential information, and a building-block approach makes even the most complex concepts simple to grasp. In addition to three new chapters, this edition includes a stronger focus on the nursing process, clinical judgment, and preparation for the Next-Generation NCLEX® Examination.

Viewing transportation through the lens of current social, economic, and policy aspects, this four-volume reference work explores the topic of transportation across multiple disciplines within the social sciences and related areas, including geography, public policy, business, and economics. The book’s articles, all written by experts in the field, seek to answer such questions as: What has been the legacy, not just economically but politically and socially as well, of President Eisenhower’s modern interstate highway system in America? With that system and the infrastructure that supports it now in a state of decline and decay, what’s the best path for the future at a time of enormous fiscal constraints? Should California politicians plunge ahead with plans for a high-speed rail that every expert says—despite the allure—will go largely unused and will never pay back the massive investment while at this very moment potholes go unfilled all across the state? What path is best for emerging countries to keep pace with dramatic economic growth for their part? What are the social and financial costs of gridlock in our cities? Features: Approximately 675 signed articles authored by prominent scholars are arranged in A-to-Z fashion and conclude with Further Readings and cross references. A Chronology helps readers put individual events into historical context; a Reader’s Guide organizes entries by broad topical or thematic areas; a detailed index helps users quickly locate entries of most immediate interest; and a Resource Guide provides a list of journals, books, and associations and their websites. While articles were written to avoid jargon as much as possible, a Glossary provides quick definitions of technical terms. To ensure full, well-rounded coverage of the field, the General Editor with expertise in urban planning, public policy, and the environment worked alongside a Consulting Editor with a background in Civil Engineering. The index, Reader’s Guide, and cross references combine for thorough search-and-browse capabilities in the electronic edition. Available in both print and electronic formats, Encyclopedia of Transportation is an ideal reference for libraries and those who want to explore the issues that surround transportation in the United States and around the world.

From New York Times bestselling author and pastor Timothy Keller, a book about facing the death of loved ones, as well as our own inevitable death Significant events such as birth, marriage, and death are milestones in our lives in which we experience our greatest happiness and our deepest grief. And so it is profoundly important to understand how to approach and experience these occasions with grace, endurance, and joy. In a culture that does its best to deny death, Timothy Keller--theologian and bestselling author--teaches us about facing death with the resources of faith from the Bible. With wisdom and compassion, Keller finds in the Bible an alternative to both despair or denial. A short, powerful book, On Death gives us the tools to understand the meaning of death within God's vision of life.