Autoimmunity refers to the phenomenon whereby an organism or body mounts an immune response against its own tissues. As a medical term, autoimmunity is today used to account for any instance in which the body fails to recognise its own constituents as ‘self’, an error that results in the paradoxical situation in which self-defense (immunity, protection) manifests as self-harm (pathology). As a result, the very possibility of autoimmunity poses a problem for the notion of immunity and the concept of identity that underpins it: if self-protection can just as readily take the form of self-destruction, then it seems that the very identity of the self, and thus the boundary between self and other, is in question. Conceptually, autoimmunity thus challenges us to think critically about the nature of any sovereign entity or identity, be they human or nonhuman, cells, nations, or other forms of community. This volume reflects and engages with different disciplinary approaches to autoimmunity in the theoretical, medical or posthumanities, social and political theory, and critical science studies. It aims to provide a topical intervention within the current discussion on biopolitical thought and critical posthumanist futures. This book was originally published as a special issue of Parallax.

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

This book discusses the various mechanisms by which food can trigger autoimmunity, thus turning a patient's own immune system against him. Readers will learn about the vital role of oral tolerance in immunity, the history of food allergy testing, difference between food allergy and food immune reactivity, the gut-brain-immune system axis, and discover how the blood-brain barrier and its integrity is connected to neuroautoimmunity and neurodegeneration. It ends with concrete workable suggestions on how to repair or restore broken immunity, or maintain a healthy immune system. This book is for medical or health care practitioners whose patients have puzzling symptoms and test results that are difficult to explain; it will help practitioners give patients the answers, diagnosis, care and treatment that they deserve, and can help to prevent, halt, or even reverse the course of autoimmune disease in patients, saving them from what could be an unhappy lifetime of suffering

Tending Adam's Garden describes and explains the way in which our immune system works from a novel perspective. The book uses metaphors and examples to bring the immune system to life and explores the fundamental miracle of nature. Written in plain language for a broad audience, this book encompasses much more than just immunology, exploring more fundamental matters such as causality, information, energy, evolution, cognition and individuality, as well as the strategy of the immune system and its role in health and disease. - Provides a unique perspective on the immune system from one of the keenest scientific and philosophical brains in the world - Uses metaphors and case histories to explore themes in an accessible manner - Written in plain language requiring no specialized vocabulary or specific scientific background in the subject

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

The Autoimmune Diseases is composed of 25 chapters dealing with different aspects of some specific autoimmune diseases. The book begins with the elucidation of the genetic predisposition to autoimmune diseases. Subsequent chapters explore numerous kinds of autoimmune diseases. Other chapters describe the antireceptor antibodies and the sensitivity and specificity of autoantibody testing. This book is designed to provide a deeper understanding of this increasingly important field of medical science for physicians and investigators involved in the diagnosis, treatment, or research of autoimmune diseases.

According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.