Astrocytes And Epilepsy
Download Astrocytes And Epilepsy full books in PDF, epub, and Kindle. Read online free Astrocytes And Epilepsy ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads.
Author |
: Jacqueline A. Hubbard |
Publisher |
: Academic Press |
Total Pages |
: 395 |
Release |
: 2016-07-05 |
ISBN-10 |
: 9780128026243 |
ISBN-13 |
: 0128026243 |
Rating |
: 4/5 (43 Downloads) |
Synopsis Astrocytes and Epilepsy by : Jacqueline A. Hubbard
Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. - Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume - Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions - Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Author |
: Peter Bedner |
Publisher |
: Biota Publishing |
Total Pages |
: 91 |
Release |
: 2015-08-01 |
ISBN-10 |
: 9781615047154 |
ISBN-13 |
: 1615047158 |
Rating |
: 4/5 (54 Downloads) |
Synopsis Crucial Role for Astrocytes in Epilepsy by : Peter Bedner
This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear. Neurosurgical specimens from patients presenting with mesial temporal lobe epilepsy (MTLE) demonstrate marked reactive gliosis. Since recent studies have implicated astrocytes in important physiological roles in the CNS, such as synchronization of neuronal firing, it is plausible that they may also have a role in seizure generation and/or seizure spread. In support of this view, various membrane channels, receptors, and transporters in astrocytic membranes are altered in the epileptic brain. Excitingly, recent evidence suggests that in the course of the pathogenesis of MTLE, these glial changes alter homeostatic network functions and temporally precede the alterations in neurons. These findings might eventually classify MTLE as a glial rather than a neuronal disorder, and identify astrocytes as promising new targets for the development of more specific antiepileptogenic therapeutic strategies. Although research on astrocytes in epilepsy is still in its infancy, this book clearly demonstrates a critical role of astrocytes in the disturbance of K+ and transmitter homeostasis and its impact on seizure generation.
Author |
: Jeffrey Noebels |
Publisher |
: OUP USA |
Total Pages |
: 1258 |
Release |
: 2012-06-29 |
ISBN-10 |
: 9780199746545 |
ISBN-13 |
: 0199746540 |
Rating |
: 4/5 (45 Downloads) |
Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author |
: Simon Shorvon |
Publisher |
: Cambridge University Press |
Total Pages |
: 1013 |
Release |
: 2019-05-02 |
ISBN-10 |
: 9781108420754 |
ISBN-13 |
: 1108420753 |
Rating |
: 4/5 (54 Downloads) |
Synopsis The Causes of Epilepsy by : Simon Shorvon
Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Author |
: Eliana Scemes |
Publisher |
: CRC Press |
Total Pages |
: 425 |
Release |
: 2016-04-19 |
ISBN-10 |
: 9781439825853 |
ISBN-13 |
: 1439825858 |
Rating |
: 4/5 (53 Downloads) |
Synopsis Astrocytes by : Eliana Scemes
Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellul
Author |
: Baoman Li |
Publisher |
: Springer Nature |
Total Pages |
: 368 |
Release |
: 2021-12-09 |
ISBN-10 |
: 9783030773755 |
ISBN-13 |
: 3030773752 |
Rating |
: 4/5 (55 Downloads) |
Synopsis Astrocytes in Psychiatric Disorders by : Baoman Li
This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.
Author |
: Gonzalo Alarcón |
Publisher |
: Cambridge University Press |
Total Pages |
: 641 |
Release |
: 2012-04-26 |
ISBN-10 |
: 9780521691581 |
ISBN-13 |
: 0521691583 |
Rating |
: 4/5 (81 Downloads) |
Synopsis Introduction to Epilepsy by : Gonzalo Alarcón
Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
Author |
: Sandra Henriques Vaz |
Publisher |
: Frontiers Media SA |
Total Pages |
: 152 |
Release |
: 2023-10-30 |
ISBN-10 |
: 9782832537367 |
ISBN-13 |
: 2832537367 |
Rating |
: 4/5 (67 Downloads) |
Synopsis Astrocytic Synaptic Plasticity in Epilepsy: From Synapses to Circuits by : Sandra Henriques Vaz
Author |
: Samden Lhatoo |
Publisher |
: Oxford University Press, USA |
Total Pages |
: 395 |
Release |
: 2012-12-20 |
ISBN-10 |
: 9780199659043 |
ISBN-13 |
: 0199659044 |
Rating |
: 4/5 (43 Downloads) |
Synopsis Oxford Textbook of Epilepsy and Epileptic Seizures by : Samden Lhatoo
Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.
Author |
: Andrea Bernasconi |
Publisher |
: Cambridge University Press |
Total Pages |
: 263 |
Release |
: 2019-01-10 |
ISBN-10 |
: 9781107108356 |
ISBN-13 |
: 1107108357 |
Rating |
: 4/5 (56 Downloads) |
Synopsis Imaging Biomarkers in Epilepsy by : Andrea Bernasconi
Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.