Annotation The field of toxicology has developed a well-characterized set of techniques to assess the behavioral and histopathological consequences of exposure to environmental insults using a number of animal models. These techniques are suitable for determining crude endpoints of exposure such as death, but are not optimal for assessing the more subtle effects of very low level or multi-agent chemical exposures, nor do they offer mechanistic explanations at the molecular level. This book is designed to have a mix of chapters devoted to classical toxicology followed by those focused more on the emerging techniques of toxicogenomics and proteomics. In this way, the relevance of new technologies such as gene arrays to classical toxicologic problems is made evident. Finally, because the worst of the world's toxicology problems reside in developing nations while the latest technical developments are occurring in the industrial nations, we sought to provide a balance of both scientific and geographical perspectives from researchers engaged in toxicology and public health research.

The history of biological weapons (BW), chemical weapons (CW), and nuclear weapons is complicated. It can be disturbing, tragic, and occasionally encouraging. It is rarely amusing, although the names selected for certain weapons suggest a casualness toward the consequences of their use: Atomic Annie, Blue Peacock, Dew of Death, Fat Man, Flying cow, George, Gilda, Helen of Bikini, Hurricane, Katie, Little Boy, Lulu, Mike, Red Beard, Sewer Pipe, Squirt. Use of BW and CW in warfare has produced mixed results in terms of effecting the outcome of a battle or campaign; despite this mixed record, both weapon types have attracted intense interest and strong advocacy for further use. The sole experience with use of nuclear weapons in warfare is viewed as hastening surrender by Japan, created competition among nations to develop more such weapons, and influenced efforts to ban any use or even stockpiling of such weapons. Each of these three weapon types has its own peculiar history, as recounted in this dictionary. This second edition of Historical Dictionary of Nuclear, Biological and Chemical Warfare contains a chronology, an introduction, and an extensive bibliography. The dictionary section has over 700 cross-referenced entries onterms related to NBC warfare, ranging from basic descriptions of substances used to details on incidents and episodes where NBC weapons were used, historical events, persons important to NBC warfare, countries where such weapons have been developed or used, and international treaties and treaty-related organizations.

Human experience with nuclear, biological, and chemical (NBC) warfare has been limited, especially in comparison to conventional forms of warfare. Our experience with nuclear warfare is confined to a period of less than one week during the end of World War II, when the United States successfully used two nuclear weapons against targets in Japan. The course of biological warfare and modern use of biological weapons are difficult to track owing to the difficulty of differentiating deliberate use from natural outbreaks. However, the keen potential of biological weapons in acts of terror was shown in the mass disruption caused in the fall 2001 experience in the U.S. with the release of anthrax through the American postal system. Chemical weapons have been used in a handful of conflicts since their introduction to modern warfare during World War I, most recently during the Iran-Iraq War during the 1980s. Despite this limited experience, NBC warfare continues to exert a certain fascination among states. The A to Z of Nuclear, Biological, and Chemical Warfare covers the development and use of NBC weapons as well as efforts to limit or control the use of these weapons through a chronology, a bibliography, an introductory essay, and dictionary entries. Over 500 cross-referenced dictionary entries provide a unique selection of terms related to NBC warfare, ranging from basic descriptions of substances used in NBC warfare to details on incidents and episodes where NBC weapons were used. Entries are structured around historical events, persons important to NBC warfare, countries where such weapons have been developed or used, and international treaties and treaty-related organizations.

The book opens with chapters that focus on the development of molecular diagnostic tools and these are followed by chapters on genetic evolution and its relationship to pathogenicity. Other topics include Brucella comparative genomics and proteomics, analysis of the structure, biosynthesis and biology of glucans and lipopolysaccharides, pathogenicity, approaches to vaccine development, bacterium-host interactions, immune response, and much more. Essential reading for everyone with an interest in Brucella and brucellosis and recommended reading for the wider body of scientists with an interest in microbial diagnostics, microbial pathogenesis, cellular microbiology and immunology, and vaccine development.

This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways-leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.

Microbial Forensics is a rapidly evolving scientific discipline. In the last decade, and particularly due to the anthrax letter attacks in the United States, microbial forensics has become more formalized and has played an increasingly greater role in crime investigations. This has brought renewed interest, development and application of new technologies, and new rules of forensic and policy engagement. It has many applications ranging from biodefense, criminal investigations, providing intelligence information, making society more secure, and helping protect precious resources, particularly human life. A combination of diverse areas is investigated, including the major disciplines of biology, microbiology, medicine, chemistry, physics, statistics, population genetics, and computer science. Microbial Forensics, Second Edition is fully revised and updated and serves as a complete reference of the discipline. It describes the advances, as well as the challenges and opportunities ahead, and will be integral in applying science to help solve future biocrimes. - A collection of microbiology, virology, toxicology and mycology as it relates to forensics, in one reference - New and expanded content to include statistical analysis of forensic data and legal admissibility and the standards of evidence, to name a few - Includes research information and application of that research to crime scene analysis, which will allow practitioners to understand and apply the knowledge to their practice with ease

The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.