The 21st century technological development is revolutionizing medicine and health care, bringing new hopes to human suffering by offering cures and treatments which were unthinkable a few decades ago. This is where anti-ageing medicine finds its niche. Anti-ageing medicine aims at slowing, arresting, and reversing phenomena associated with ageing by merging biotechnological innovation and engineered solutions. Ideally, by means of the newest medical technology, the "body machinery" should be kept fit and at peak performance all life long. Early detection of age-related dysfunction should thus be "fixed" at any age with interventions such as metabolic fine tuning, enhancement, regeneration, restoration or replacement of "body parts" (i.e. organs, skin, bone or muscle). It covers a vast array of domains: from cell therapy to pharmaceutical interventions, from bio-surgery to aesthetic surgery, from human enhancement to fortified food, from smart housing and robots to toxic-free environments. Anti-ageing medicine holds promises but also significant risks and safety issues which are addressesd in this book. It presents the latest scientific evidence on what works or does not work. It also provides public policy recommendations to ensure the protection of consumers and their rights while encouraging research and development. This book is intended for academics, health professionals, business persons, consumers and policy-makers interested in the latest evidence and ethical issues about anti-ageing medicine.

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Aging is a treatable condition! For more than a century aging and a particular lifespan have been widely thought to be an inescapable and fundamental aspect of human existence. Indeed, Darwin's evolution theory tells us that the force of evolution is toward defeating aging, leading to the idea that aging is the result of unalterable laws of physics or chemistry. We can find different treatments for different age-related diseases like cancer and heart disease but aging is itself an untreatable fact of life. Today it is increasingly clear that aging is actually the result of complex biological programs that purposely limit lifespan in humans and most animals because this created an evolutionary advantage for populations of wild animals including our prehistoric ancestors. Programmed aging and supporting evolutionary concepts are a logical consequence of relatively recent discoveries in genetics as well as observations regarding the aging and lifespan characteristics of many different organisms. As a consequence, we can increase healthy human lifespan by interfering with the aging program. Interfering with a biological process is a familiar problem in medicine, and research toward developing treatments based on this idea are underway. Goldsmith describes the 160-year history of still-unresolved scientific arguments over the evolutionary nature of aging, the increasing empirical evidence of aging programs, and the exciting prospects for lifespan extension and healthy living. More practically, the book describes: Key observations about the nature of aging. Orally administered substances known to increase longevity in mice. Why exercise increases longevity. Anti-aging medicine issues with existing health care systems. Social, educational, ethical, and economic issues with extending lifespan. How lifespan extension concepts add to our ability to devise treatments for age-related diseases. Contents 1. Introduction 2. Nature of Aging and Lifespan 3. Evolution Theory and Aging 4. Evidence Supporting Programmed Aging 5. U.S. Health System Summary 6. Exercise and Activity - Effects on Aging 7. Non-Science Factors Favor Non-Programmed Aging 8. Programmed vs Non-Programmed Aging - Current Status 9. Anti-Aging Research 10. Anti-Aging Medicine 11. Conclusion 12. Free Resources and Further Reading 13. Author's Notes 14. Appendix 15. Glossary 16. References

Aging Men, Masculinities and Modern Medicine explores the multiple socio-historical contexts surrounding men’s aging bodies in modern medicine from a global perspective. The first of its kind, it investigates the interrelated aspects of aging, masculinities and biomedicine, allowing for a timely reconsideration of the conceptualisation of aging men within the recent explosion of social science studies on men’s health and biotechnologies including anti-aging perspectives. This book discusses both healthy and diseased states of aging men in medical practices, bringing together theoretical and empirical conceptualisations. Divided into four parts it covers: Historical epistemology of aging, bodies and masculinity and the way in which the social sciences have theorised the aging body and gender. Material practices and processes by which biotechnology, medical assemblages and men’s aging bodies relate to concepts of health and illness. Aging experience and its impact upon male sexuality and identity. The importance of men’s roles and identities in care-giving situations and medical practices. Highlighting how aging men’s bodies serve as trajectories for understanding wider issues of masculinity, and the way in which men’s social status and men’s roles are made in medical cultures, this innovative volume offers a multidisciplinary dialogue between sociology of health and illness, anthropology of the body and gender studies.

The first account of anti-ageing and rejuvenation in modern Britain, exploring hormones, diet, electrotherapy, exercise and skin care.

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

"Want to be healthy, vital , alert, and active on your 100th birthday? Then you must read this book." --Dr. Bob Goldman, president, National Academy of Sports Medicine Discover the Age-Reversing Benefits of Human Growth Hormone Lose Fat, Gain Muscle Increase Energy Level Increase Immune Function Enhance Sexual Performance Increase Cardiac Output Improve Skin Elasticity Remove Wrinkles Eliminate Cellulite Improve Vision Increase Memory Retention Improve Quality of Sleep Increase Exercise Performance Lower Blood Pressure Improve Cholesterol Profile Increase Bone Mass Quicken Wound Healing

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.