An Introduction To Drug Synthesis
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Author |
: Graham L. Patrick |
Publisher |
: |
Total Pages |
: |
Release |
: 2015 |
ISBN-10 |
: 0191073474 |
ISBN-13 |
: 9780191073472 |
Rating |
: 4/5 (74 Downloads) |
Synopsis An Introduction to Drug Synthesis by : Graham L. Patrick
An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.
Author |
: Graham L. Patrick |
Publisher |
: Oxford University Press, USA |
Total Pages |
: 587 |
Release |
: 2015 |
ISBN-10 |
: 9780198708438 |
ISBN-13 |
: 0198708432 |
Rating |
: 4/5 (38 Downloads) |
Synopsis An Introduction to Drug Synthesis by : Graham L. Patrick
Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.
Author |
: Douglas S. Johnson |
Publisher |
: John Wiley & Sons |
Total Pages |
: 295 |
Release |
: 2013-02-26 |
ISBN-10 |
: 9781118678466 |
ISBN-13 |
: 111867846X |
Rating |
: 4/5 (66 Downloads) |
Synopsis The Art of Drug Synthesis by : Douglas S. Johnson
The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.
Author |
: Jie Jack Li |
Publisher |
: John Wiley & Sons |
Total Pages |
: 238 |
Release |
: 2004-12-27 |
ISBN-10 |
: 9780471686736 |
ISBN-13 |
: 0471686735 |
Rating |
: 4/5 (36 Downloads) |
Synopsis Contemporary Drug Synthesis by : Jie Jack Li
An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.
Author |
: Jie Jack Li |
Publisher |
: John Wiley & Sons |
Total Pages |
: 371 |
Release |
: 2013-03-27 |
ISBN-10 |
: 9781118701249 |
ISBN-13 |
: 1118701240 |
Rating |
: 4/5 (49 Downloads) |
Synopsis Modern Drug Synthesis by : Jie Jack Li
Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.
Author |
: Richard B. Silverman |
Publisher |
: Elsevier |
Total Pages |
: 650 |
Release |
: 2012-12-02 |
ISBN-10 |
: 9780080513379 |
ISBN-13 |
: 0080513379 |
Rating |
: 4/5 (79 Downloads) |
Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Author |
: Peter J. Harrington |
Publisher |
: John Wiley & Sons |
Total Pages |
: 815 |
Release |
: 2011-02-23 |
ISBN-10 |
: 9780470922866 |
ISBN-13 |
: 0470922869 |
Rating |
: 4/5 (66 Downloads) |
Synopsis Pharmaceutical Process Chemistry for Synthesis by : Peter J. Harrington
There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
Author |
: Ruben Vardanyan |
Publisher |
: Academic Press |
Total Pages |
: 870 |
Release |
: 2016-01-07 |
ISBN-10 |
: 9780124115248 |
ISBN-13 |
: 0124115241 |
Rating |
: 4/5 (48 Downloads) |
Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan
Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Author |
: Ashish Tewari |
Publisher |
: Elsevier |
Total Pages |
: 384 |
Release |
: 2018-04-17 |
ISBN-10 |
: 9780081022740 |
ISBN-13 |
: 0081022743 |
Rating |
: 4/5 (40 Downloads) |
Synopsis Synthesis of Medicinal Agents from Plants by : Ashish Tewari
Synthesis of Medicinal Agents from Plants highlights the importance of synthesizing medicinal agents from plants and outlines methods for performing it effectively. Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from natural sources. Chapters then explore the medicinal properties of a number of important plants, before concluding with a discussion of the future of drugs from medicinal plants. Illustrated with real-world examples, it is a practical resource for researchers in this field. In an age of rapid environmental destruction, hundreds of medicinal plants are at risk of extinction from overexploitation and deforestation, limiting the natural resources available for active agent extraction, thereby threatening the discovery of future cures for diseases. Simultaneously, with the increasing population and advances in medical sciences, the demand for drugs is continuously increasing and cannot be met with just plants. The ability to synthetically replicate the active compounds from these plants is essential in creating an ecologically-aware, sustainable future for drug design - Includes detailed coverage of therapeutic compound synthesis - Uses multiple real-world examples to support content - Lays out a sustainable template for the future of developing active agents from natural products
Author |
: Ruben Vardanyan |
Publisher |
: Elsevier |
Total Pages |
: 635 |
Release |
: 2006-03-10 |
ISBN-10 |
: 9780080462127 |
ISBN-13 |
: 008046212X |
Rating |
: 4/5 (27 Downloads) |
Synopsis Synthesis of Essential Drugs by : Ruben Vardanyan
Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references