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Theoretical arguments associate labor migration and regional innovation capacity are based on technological innovation and knowledge diffusion that stimulate productivity increase in firms, institutions and regions. Labor mobility may contribute efficiently in the knowledge spillover and diffusion and because migrants can utilizes the knowledge and skill they gain from parental institutions which exploit in the host country. The migrated skill worker increase the knowledge accumulation and spillover which leads to increase the productivity of firm, institutions and region. Human capital migration is essential for knowledge diffusion because it enables the transfer of tacit information between businesses or institutions, enhancing productivity. In this context of externalities generation, skilled labor mobility is an important mechanism for the interregional transfer of technological knowledge diffusion.