This book brings together recent developments in Alzheimer's disease research with related discoveries in the field of cell biology. The book moves between basic cell biological concepts that form the underpinnings of modern Alzheimer's disease research, and current findings about proteins and cellular processes affected by the disease. Divided into three topics, the book addresses (1) protein trafficking, a problem that has become germane to the study of the amyloid precursor protein; (2) phosphorylation, a problem that underlies studies of the pathological transformation of tau to paired helical filaments; and (3) cell death, a pervasive problem in neurodegeneration.

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It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

This volume constitutes the proceedings of the Third European Symposium on Research in Computer Security, held in Brighton, UK in November 1994. The 26 papers presented in the book in revised versions were carefully selected from a total of 79 submissions; they cover many current aspects of computer security research and advanced applications. The papers are grouped in sections on high security assurance software, key management, authentication, digital payment, distributed systems, access control, databases, and measures.

This volume presents the proceedings of the Second Annual European Symposium on Algorithms (ESA '94), held near Utrecht, The Netherlands in September 1994. ESA is the premier European conference on algorithms. The 42 papers presented were selected from a total of 159 submissions and reflect many of the current directions in algorithm research. The volume is organized into chapters on automatic graph drawing and rendering, spanners and Steiner trees, efficient data structures and complexity analysis, graph algorithms, distributed algorithms, computational geometry and its applications, operations research and combinatorial optimization, parallel computation and interconnection networks, complexity theory, and text processing

This book constitutes the refereed proceedings of the 10th International Symposium on Algorithms and Computation, ISAAC'99, held in Chennai, India, in December 1999. The 40 revised full papers presented together with four invited contributions were carefully reviewed and selected from 71 submissions. Among the topics covered are data structures, parallel and distributed computing, approximation algorithms, computational intelligence, online algorithms, complexity theory, graph algorithms, computational geometry, and algorithms in practice.

This book constitutes the refereed proceedings of the 10th International Symposium on Algorithms and Computation, ISAAC'99, held in Chennai, India, in December 1999. The 40 revised full papers presented together with four invited contributions were carefully reviewed and selected from 71 submissions. Among the topics covered are data structures, parallel and distributed computing, approximation algorithms, computational intelligence, online algorithms, complexity theory, graph algorithms, computational geometry, and algorithms in practice.