This book brings together recent developments in Alzheimer's disease research with related discoveries in the field of cell biology. The book moves between basic cell biological concepts that form the underpinnings of modern Alzheimer's disease research, and current findings about proteins and cellular processes affected by the disease. Divided into three topics, the book addresses (1) protein trafficking, a problem that has become germane to the study of the amyloid precursor protein; (2) phosphorylation, a problem that underlies studies of the pathological transformation of tau to paired helical filaments; and (3) cell death, a pervasive problem in neurodegeneration.

9

This book constitutes the refereed proceedings of the 10th International Symposium on Algorithms and Computation, ISAAC'99, held in Chennai, India, in December 1999. The 40 revised full papers presented together with four invited contributions were carefully reviewed and selected from 71 submissions. Among the topics covered are data structures, parallel and distributed computing, approximation algorithms, computational intelligence, online algorithms, complexity theory, graph algorithms, computational geometry, and algorithms in practice.

This volume constitutes the proceedings of the Third European Symposium on Research in Computer Security, held in Brighton, UK in November 1994. The 26 papers presented in the book in revised versions were carefully selected from a total of 79 submissions; they cover many current aspects of computer security research and advanced applications. The papers are grouped in sections on high security assurance software, key management, authentication, digital payment, distributed systems, access control, databases, and measures.

This book constitutes the refereed proceedings of the 10th International Symposium on Algorithms and Computation, ISAAC'99, held in Chennai, India, in December 1999. The 40 revised full papers presented together with four invited contributions were carefully reviewed and selected from 71 submissions. Among the topics covered are data structures, parallel and distributed computing, approximation algorithms, computational intelligence, online algorithms, complexity theory, graph algorithms, computational geometry, and algorithms in practice.

The optimistic predictions of a number of microbiologists notwithstanding, the past decade has not signaled the end of infectious disease, but rather an introduction to a host of new and complex microorganisms and their resulting depredations on humanity. The identification of new pathogens, such as the causative agent of Lyme disease and the Human Immuno-deficiency Virus (HIV), as well as the Hepatitis Delta Virus (HDV) has not only revealed new forms of clinical pathology, but new and unexpected variations on the life cycle and the molecular biology of the pathogens. In this volume a number of the leaders in the field of Hepatitis Delta virus research, ranging from clinicians and virologists to molecular biologists and biochemists describe what in their experience typifies some of these unique features.

This Festschrift was published in honor of Hans L. Bodlaender on the occasion of his 60th birthday. The 14 full and 5 short contributions included in this volume show the many transformative discoveries made by H.L. Bodlaender in the areas of graph algorithms, parameterized complexity, kernelization and combinatorial games. The papers are written by his former Ph.D. students and colleagues as well as by his former Ph.D. advisor, Jan van Leeuwen. Chapter “Crossing Paths with Hans Bodlaender: A Personal View on Cross-Composition for Sparsification Lower Bounds” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This volume presents the proceedings of the First International workshop on Parallel Scientific Computing, PARA '94, held in Lyngby, Denmark in June 1994. It reports interdisciplinary work done by mathematicians, scientists and engineers working on large-scale computational problems in discussion with computer science specialists in the field of parallel methods and the efficient exploitation of modern high-performance computing resources. The 53 full refereed papers provide a wealth of new results: an up-to-date overview on high-speed computing facilities, including different parallel and vector computers as well as workstation clusters, is given and the most important numerical algorithms, with a certain emphasis on computational linear algebra, are investigated.

This volume presents the proceedings of the 1995 International Conference on Database Theory, ICDT '95, held in Prague in January 1995. Besides two full invited papers and the abstracts of two tutorials, the book includes the revised full versions of 29 technical contributions selected from a total of 116 submissions. The papers address all current aspects of database theory; they are organized in sections on optimization, nonmonotonic semantics, query languages, concurrency control, advanced models, probabilistic methods, constraints and dependencies, and Datalog analysis.

Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.