This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.

Optical microscopy and associated technologies have advanced rapidly along with laser technology. These techniques have stimulated further development of the optical imaging theory, including 3-dimensional microscopy imaging theory, the theory of imaging with ultrashort pulsed beam illumination and the aberration theory for high numerical-aperture objectives. This book introduces these new theories in modern optical microscopy, providing comparisons with classical imaging as appropriate.

Advances in Computerized Analysis in Clinical and Medical Imaging book is devoted for spreading of knowledge through the publication of scholarly research, primarily in the fields of clinical & medical imaging. The types of chapters consented include those that cover the development and implementation of algorithms and strategies based on the use of geometrical, statistical, physical, functional to solve the following types of problems, using medical image datasets: visualization, feature extraction, segmentation, image-guided surgery, representation of pictorial data, statistical shape analysis, computational physiology and telemedicine with medical images. This book highlights annotations for all the medical and clinical imaging researchers’ a fundamental advances of clinical and medical image analysis techniques. This book will be a good source for all the medical imaging and clinical research professionals, outstanding scientists, and educators from all around the world for network of knowledge sharing. This book will comprise high quality disseminations of new ideas, technology focus, research results and discussions on the evolution of Clinical and Medical image analysis techniques for the benefit of both scientific and industrial developments. Features: Research aspects in clinical and medical image processing Human Computer Interaction and interface in imaging diagnostics Intelligent Imaging Systems for effective analysis using machine learning algorithms Clinical and Scientific Evaluation of Imaging Studies Computer-aided disease detection and diagnosis Clinical evaluations of new technologies Mobility and assistive devices for challenged and elderly people This book serves as a reference book for researchers and doctoral students in the clinical and medical imaging domain including radiologists. Industries that manufacture imaging modality systems and develop optical systems would be especially interested in the challenges and solutions provided in the book. Professionals and practitioners in the medical and clinical imaging may be benefited directly from authors’ experiences.

A picture says more than a thousand words. This is something that we all know to be true. Imaging has been important since the early days of medicine and bi- ogy, as seen in the anatomical studies of Leonardo Da Vinci or Andreas Vesalius. More than 100 years ago, the ?rst noninvasive imaging technologies, such as K- rad Roentgen’s X-ray technology,were applied to the medical ?eld—and while still crude—revolutionized medical diagnosis. Today, every patient will be exposed to some kind of advanced imaging technology such as medical resonance imaging, computed tomography or four-dimensional ultrasound during their lifetime. Many diseases, such as brain tumors, are initially diagnosed solely by imaging, and most of the surgical planning relies on the patient imagery. 4D ultrasound is available to expecting parents who wish to create unique early memories of the new baby, and it may soon be used for the morphometric diagnosis of malformations that may one day be treatable—inutero! Light and electron microscopy are unequal brethren, which have contributed to most of our knowledge about the existence and organization of cells, tissues and microorganisms. Every student of biology or medicine is introduced to the fascinating images of the microcosm. New advances have converted these im- ing technologies, which were considered by many to be antiquated, into powerful tools for research in systems biology and related ?elds.

Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.

This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

Computerized medical imaging and image analysis have been the central focus in diagnostic radiology. They provide revolutionalizing tools for the visualization of physiology as well as the understanding and quantitative measurement of physiological parameters. This book offers in-depth knowledge of medical imaging instrumentation and techniques as well as multidimensional image analysis and classification methods for research, education, and applications in computer-aided diagnostic radiology. Internationally renowned researchers and experts in their respective areas provide detailed descriptions of the basic foundation as well as the most recent developments in medical imaging, thus helping readers to understand theoretical and advanced concepts for important research and clinical applications.

This landmark text from world-leading radiologist describes and illustrates how imaging techniques are created, analyzed and applied to biomedical problems.

This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.

This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science.