This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.

Heart Valves—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Pulmonary Valve. The editors have built Heart Valves—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pulmonary Valve in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Heart Valves—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Heart Valves: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Heart Valves. The editors have built Heart Valves: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Heart Valves in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Heart Valves: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.

Because of developments in powerful computer technology, computational techniques, advances in a wide spectrum of diverse technologies, and other advances coupled with cross disciplinary pursuits between technology and its greatly significant applied implications in human body processes, the field of biomechanics is evolving as a broadly significant area. The four volumes of Biomechanical Systems, Techniques, and Applications explore the many areas of significant advances, including dynamics of musculo-skeletal systems; mechanics of hard and soft tissues, muscles, bone remodeling, hard and soft tissue interfaces, blood flow, air flow, flow-prosthesis interfaces, and impact; cardiovascular and respiratory biomechanics; and dynamics of many machine interactions.

Because of rapid developments in computer technology and computational techniques, advances in a wide spectrum of technologies, coupled with cross-disciplinary pursuits between technology and its application to human body processes, the field of biomechanics continues to evolve. Many areas of significant progress include dynamics of musculoskeletal systems, mechanics of hard and soft tissues, mechanics of bone remodeling, mechanics of blood and air flow, flow-prosthesis interfaces, mechanics of impact, dynamics of man-machine interaction, and more. Thus, the great breadth and significance of the field in the international scene require a well integrated set of volumes to provide a complete coverage of the exciting subject of biomechanical systems technology. World-renowned contributors tackle the latest technologies in an in-depth and readable manner. . Sample Chapter(s). Chapter 1: A Simulation Study of Hemodynamic Benefits and Optimal Control of Axial Flow Pump-Based Left Ventricular Assist. Contents: Techniques in Visualization and Evaluation of the In Vivo Microcirculation (S Ichioka); Analyzing Cardiac Biomechanics by Heart Sound (A Voss et al.); Numerical and Experimental Techniques for the Study of Biomechanics in the Arterial System (T P O''Brien et al.); and many other papers. Readership: Academics, researchers and postgraduate students in anatomy, cardiology, orthopaedic, biomechanics and surgery.

Heart Valves—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Heart Valves. The editors have built Heart Valves—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Heart Valves in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Heart Valves—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Valvular heart disease is a highly prevalent and increasingly clinically addressed problem worldwide, with evolving treatment guidelines supporting earlier intervention as well as valve repair over replacement when possible. Most valvular pathologies are rooted in biomechanical changes, such as the nuanced interplay between tissue degeneration, valve kinematics, and cardiac function. However, advances in repair techniques have progressed in the clinical arena primarily based upon anatomic and physiologic premises. Thus, by using biomechanical engineering tools to investigate valvular disease and analyze treatments, quantitative data can be harnessed to optimize surgical repair techniques and devices. An innovative left heart simulator was designed and produced to study the mechanics of mitral and aortic valve specimens throughout the cardiac cycle. This ex vivo analysis enables rapid and safe testing of surgical operations and offers new insight into the nuances of valvular disease and repair. This dissertation first details significant advancements to heart simulator technology: the development of low-profile chordal strain gauges, coupled image-guided robots to replicate papillary muscle motion, and two mitral annular dilation devices. Building on this heart simulator technology foundation, novel disease models were developed and analyzed: Barlow's mitral valve disease, aortic regurgitation from cusp prolapse, and bicuspid aortic valve disease. Finally, facilitated by the simulator and modeling advancements, I analyzed contemporary operative techniques and devices: valve-sparing root replacement, posterior ventricular anchoring neochordal repair, and transapical neochordal repair devices. A novel artificial papillary muscle device was also designed and tested to integrate with current minimally invasive mitral valve repair devices under trials. The research outlined herein has resulted in a significant clinical impact on aortic and mitral valve repair, and this work will continue to serve as a foundation for future investigations of clinical therapies for valve disease that can be rapidly translated to intraoperative patient care.

Over the past 15 years, mechanical valves, and in particular, bileaflet mechanical valves, have made considerable strides in durability and hemodynamic per- formance. However, biocompatibility in terms of thrombo- embolism, thrombosis, and hemolysis has remained an area where improvement is needed. "New Development in Bileaflet Mechanical Heart Valve" discusses advances in these important areas of prosthetic valve function and provides clinical experience with a new open pivot, bileaflet mechanical valve.