Selected papers from the 2011 International Conference on Advanced Design and Manufacturing Engineering (ADME 2011), 16-18 September, 2011, Guangzhou, China

This book constitutes the refereed proceedings of the 25th International Conference on Parallel Computational Fluid Dynamics, ParCFD 2013, held in Changsha, China, in May 2013. The 35 revised full papers presented were carefully reviewed and selected from more than 240 submissions. The papers address issues such as parallel algorithms, developments in software tools and environments, unstructured adaptive mesh applications, industrial applications, atmospheric and oceanic global simulation, interdisciplinary applications and evaluation of computer architectures and software environments.

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.

This book, containing only papers subjected to strict peer-review by experts, covers the subject areas of innovative design methodology, product life-cycle design, intelligent optimization design, structural strength and robustness, reverse engineering, green design and manufacturing, design for sustainability, dynamics of machinery, new mechanisms and robotics, driven-train mechanisms, complex electro-mechanical system design, advanced CAE techniques and other related topics. It thus represents a veritable handbook guide to the topics covered.

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

The peer-reviewed papers making up this book cover the subject areas of: materials and their applications, mechatronics, industrial robotics and automation, machine vision, sensor technology, micro-electronic technology, measure control technologies and intelligent systems, transmission and control of fluids, mechanical control and information processing technology, embedded systems, advanced forming manufacturing and equipment, NEMS/MEMS technology and equipment, micro-electronic packaging technology and equipment, advanced nanocomposite techniques and equipment, power and fluid machinery, energy machinery and equipment, construction machinery and equipment and other related topics. The work constitutes an invaluable guide to the subjects covered. Review from Book News Inc.: Volume one of this three-volume set from the September 2011 conference presents recent research on manufacturing materials, mechatronics, industrial robotics, and automation. Volume two explores machine vision, sensors, microelectronic technology, measure control, intelligent systems, transmission, mechanical control, MEMS, and embedded systems. The last volume focuses on micro-electronic packaging, advanced NC techniques, power and fluid machinery, energy equipment, and construction machinery. Four papers from the Zhengzhou University of Light Industry analyze the movement of a multi-legged walking robot with hand-foot integration. Other topics of the 480 papers include green synthesis of silver nanoparticles, a new aluminum anode for deepwater cathodic protection, inspection of fruit surface defects by computer vision, hydraulic dynamic equilibrium in household heating systems, and preparation of crayfish flavoring by fermentation.

Power Ultrasonics: Applications of High-Intensity Ultrasound, Second Edition provides a comprehensive reference on the fundamentals, processing, engineering, medical, food and pharmaceutical applications of ultrasonic processing. Chapters cover the fundamentals of nonlinear propagation of ultrasonic waves in fluids and solids, discuss the materials and designs of power ultrasonic transducers and devices, identify applications of high power ultrasound in materials engineering and mechanical engineering, food processing technology, environmental monitoring and remediation and industrial and chemical processing (including pharmaceuticals), medicine and biotechnology, and cover developments in ultrasound therapy and surgery applications.The new edition also includes recent advances in modeling, characterization and measurement techniques, along with additive manufacturing and micromanufacturing. This is an invaluable reference for graduate students and researchers working in the disciplines of materials science and engineering. In addition, those working on the physics of acoustics, sound and ultrasound, sonochemistry, acoustic engineering and industrial process technology, R&D managers, production, and biomedical engineers will find it useful to their work. - Covers the fundamentals of nonlinear propagation of ultrasonic waves in fluids and solids - Discusses the materials and designs of power ultrasonic transducers and devices - Considers state-of-the-art power sonic applications across a wide range of industries

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Urban Construction and Management Engineering IV focuses on the research of construction technology and the engineering management in urban construction. This proceedings gathers the most cutting-edge research and achievements, and will provide scholars and engineers with preferable research directions and engineering solutions as reference. Subjects in this proceedings include: Civil Engineering Engineering Structure Engineering Management Low Carbon City Urban Management The works of this proceedings encourages development of civil engineering and construction technology. Thereby, the work promotes scientific information interchange between scholars from the top universities, research centers and high-tech enterprises working all around the world.