This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.

Phytochemicals are receiving increasing attention due to their observed nutritional and health-promoting effects in numerous food applications. As plant secondary metabolites with bioactive properties, they may provide desirable health benefits beyond basic nutrition to reduce chronic disease conditions. Their importance in nutrition and health cannot be overstated as it has generated so much interest and studies focused on elucidating their roles has produced so many outstanding results. Plant phytochemicals are readily used in alternative medicine in South East Asia especially, in China and India and they are becoming widely acceptable worldwide. However, very little is still known about the phytochemicals despite these intense research efforts because of their diverse biological and chemical nature. In this newest addition to the series, Nutraceuticals: Basic Research and Clinical Applications, Plant Food Phytochemicals and Bioactive Compounds in Nutrition and Health provides a comprehensive review of the current state of knowledge in the field of bioactive plant phytochemical compounds, their food sources, bioactivities, bioavailability, extraction, production, and applications. Experts in the field discuss various bioactivities of the notable and promising plant phytochemicals of significance in nutrition and health, e.g., lowering of CVD, hypertension, cholesterol, diabetes, obesity, inflammation, cancer, oxidative stress, neurodegenerative diseases and a host of other chronic disease conditions. Key Features: Describes the various nutritional and bioactive significances of notable and promising plant phytochemicals of significance in nutritional and medical research and their food and/or plant sources Includes various approaches for the quantification, extraction and production of the notable and promising phytochemical compounds in nutrition and health Examines the challenges and promises of plant phytochemical as ingredients for the development of functional foods and nutraceuticals as well as their use in alternative medicine Discusses regulatory issues regarding plant phytochemicals, especially as it pertains to their health claims and use

Recent Developments in Nanomaterial-Based Sensing of Human Pathogens gives insights into the alignment of recent developments in the field of nano-sensing of bacterial and viral pathogenic organisms. The book describes the role of biomarkers in the detection of fungal diseases and the importance of mycoplasmas in health and diseases that are naturally resistant to many common antibiotics, such as penicillin. Touching all areas of medical microbiology and analytical biochemistry, this book provides understanding to application-oriented microbial sensing concepts and updates knowledge with respect to recent advances on related aspects of pathogenic sensing. Presents in-depth coverage of nanosensors for a wide range of human pathogens Combines insights from nanotechnology, biology, and medicine for holistic pathogen detection Shows cutting-edge progress in analytics, biomarker detection, and innovative nanodevices for improved pathogen sensing Highlights clinical importance, serving as a valuable resource for pathogen detection and diagnostics

Concepts in Immunology and Immunotherapeutics, 4th Edition provides a wide-ranging introduction to both basic and applied immunology.

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Amid ongoing shifts in the world economic and political order, the promise for future public health is tenuous. Will today's economic systems sustain tomorrow's health? Will future generations inherit fair access to health and health care? An important hope for the health of future generations is the establishment of a well-grounded, global public health system. Global Public Health: Ecological Foundations addresses both the challenges and cooperative solutions of contemporary public health, within a framework of social justice, environmental sustainability, and global cooperation. With an emphasis on ecological foundations, this book approaches public health principles-history, foundations, topics, and applications-with a community-oriented perspective. By achieving global reach through cooperative, community-based interventions, this text illustrates that the practical application of public health principles can help maintain the health of the world's people. Blending established wisdom with new perspectives, Global Public Health will stimulate better understanding of how the different streams of public health can work more synergistically to promote global health equity. It is a foundation for future public health measures to be built and to succeed.

Publisher’s Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The 10th edition of Porth’s Pathophysiology: Concepts of Altered Health Statescontinues a legacy of excellence by providing comprehensive, nursing-focused coverage designed to help grasp both the physical and psychological aspects of altered health. The book’s unique emphasis on “concepts" of altered health states, as opposed to factual descriptions of diseases and disorders, helps students grasp both the physical and psychological aspects of altered health. Porth’s Pathophysiology: Concepts of Altered Health States Tenth Edition Tommie L. Norris, DNS, RN Meet today’s clinical challenges with the trusted authority in pathophysiology Make the most of your pathophysiology course and master the knowledge to ensure clinical success. Trusted for more than 30 years and updated to reflect today’s nursing challenges, this engaging text makes complex concepts accessible and helps you easily and confidently grasp normal body function, the effects of disease on body systems, and the body’s ability to compensate and adapt. This edition also considers the many technological advances that allow healthcare providers to diagnose earlier and with more accuracy. Highlights of the Tenth Edition Approachable presentation builds understanding from basic to advanced concepts and defines key terms as you progress. “Chunked” content keeps you focused on the most critical information and helps you review salient points efficiently. Unit-Opening Case Studies, which are revisited in one or more chapters in the unit, bring pathophysiology to life and equip you for success in clinical practice. Approximately 1,000 vibrant illustrations clarify the clinical manifestations of diseases and disease processes. Understanding boxes break physiologic processes and phenomena into their sequential parts, providing insight into the many opportunities for disease to disrupt the processes. Key Points boxes and In Summary sections reduce the need for memorization and help you incorporate important points into broader conceptual units. NEW!Pediatric Considerations and Geriatric Considerations boxes in each chapter specify how the chapter content applies to these two special populations. NEW!Concept Mastery Alerts explain topics that students can find confusing. Review Exercises at the end of each chapter test your retention and identify areas for further study. References provide fast, efficient access to normal laboratory values in both conventional and SI units, as well as a comprehensive glossary. Narrated animations referenced by icons in the text and available online enhance your understanding of the most challenging and clinically relevant concepts.

In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

"A subject collection from Cold Spring Harbor Perspectives in Medicine"--title page.

This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. “What has C. elegans to do with me?” the questioning might go. “It doesn’t even have lymphocytes. ” Such skeptics may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind. So I would like to introduce the topic with a few words about the power of genetics, and why it has contributed so much to immunology, and to bi- ogy in general. Genetics, as the word is used here, is not merely the science of heredity, but much more than that. It is the science of exceptions: the science that takes note of heritable variation and seeks to explain it at the most fundamental level.