This is targeted at professionals and graduate students working in disciplines where flow of adhesive particles plays a significant role.

Offering a comprehensive treatment of adhesive particle flows, this book adopts a particle-level approach oriented toward directly simulating the various fluid, electric field, collision, and adhesion forces and torques acting on the particles, within the framework of a discrete-element model. It is ideal for professionals and graduate students working in engineering and atmospheric and condensed matter physics, materials science, environmental science, and other disciplines where particulate flows have a significant role. The presentation is applicable to a wide range of flow fields, including aerosols, colloids, fluidized beds, and granular flows. It describes both physical models of the various forces and torques on the particles as well as practical aspects necessary for efficient implementation of these models in a computational framework.

This is targeted at professionals and graduate students working in disciplines where flow of adhesive particles plays a significant role.

This thesis proposes new approaches for modelling contacting interactions and electrostatic interactions between microparticles in the framework of the discrete element method and presents a systematic investigation on the agglomeration, migration and deposition of microparticles in presence of electrostatic and flow fields. It reports an exponential-form scaling for the size distribution of early-stage agglomerates in homogeneous isotropic turbulence and formulate the agglomeration and deagglomeration rates. The evolution of spherical clouds of charged particles that migrate under the action of an external electrostatic field is then investigated. Scaling laws of cloud radius and particle number density are obtained by solving a continuum convection equation. Finally, it investigates the deposition of charged particles on a flat plane and fibers. A dimensionless adhesion parameter is constructed to predict the structure of deposits. The temporal evolution of the deposit structure, particle capture efficiency, and the pressure drop are displayed with varying values of Coulomb repulsion and adhesion magnitudes.

Discover how the latest computational tools are building our understanding of particle interactions and leading to new applications With this book as their guide, readers will gain a new appreciation of the critical role that particle interactions play in advancing research and developing new applications in the biological sciences, chemical engineering, toxicology, medicine, and manufacturing technology The book explores particles ranging in size from cations to whole cells to tissues and processed materials. A focus on recreating complex, real-world dynamical systems helps readers gain a deeper understanding of cell and tissue mechanics, theoretical aspects of multiscale modeling, and the latest applications in biology and nanotechnology. Following an introductory chapter, Multiscale Modeling of Particle Interactions is divided into two parts: Part I, Applications in Nanotechnology, covers: Multiscale modeling of nanoscale aggregation phenomena: applications in semiconductor materials processing Multiscale modeling of rare events in self-assembled systems Continuum description of atomic sheets Coulombic dragging and mechanical propelling of molecules in nanofluidic systems Molecular dynamics modeling of nanodroplets and nanoparticles Modeling the interactions between compliant microcapsules and patterned surfaces Part II, Applications in Biology, covers: Coarse-grained and multiscale simulations of lipid bilayers Stochastic approach to biochemical kinetics In silico modeling of angiogenesis at multiple scales Large-scale simulation of blood flow in microvessels Molecular to multicellular deformation during adhesion of immune cells under flow Each article was contributed by one or more leading experts and pioneers in the field. All readers, from chemists and biologists to engineers and students, will gain new insights into how the latest tools in computational science can improve our understanding of particle interactions and support the development of novel applications across the broad spectrum of disciplines in biology and nanotechnology.

"Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.

Provides an extensive and up-to-date overview of the theory and application of computational pharmaceutics in the drug development process Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 introduces a variety of current and emerging computational techniques for pharmaceutical research. Bringing together experts from academia, industry, and regulatory agencies, this edited volume also explores the current state, key challenges, and future outlook of computational pharmaceutics while encouraging development across all sectors of the field. Throughout the text, the authors discuss a wide range of essential topics, from molecular modeling and process simulation to intelligent manufacturing and quantitative pharmacology. Building upon Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0, this new edition provides a multi-scale perspective that reveals the physical, chemical, mathematical, and data-driven details of pre-formulation, formulation, process, and clinical studies, in addition to in vivo prediction in the human body and precision medicine in clinical settings. Detailed chapters address both conventional dosage forms and the application of computational technologies in advanced pharmaceutical research, such as dendrimer-based delivery systems, liposome and lipid membrane research, and inorganic nanoparticles. A major contribution to the development and promotion of computational pharmaceutics, this important resource: Discusses the development track, achievements, and prospects of computational pharmaceutics Presents multidisciplinary research to help physicists, chemists, mathematicians, and computer scientists locate problems in the field of drug delivery Covers a wide range of technologies, including complex formulations for water-insoluble drugs, protein/peptide formulations, nanomedicine, and gene delivery systems Focuses on the application of cutting-edge computational technologies and intelligent manufacturing of emerging pharmaceutical technologies Includes a systematic overview of computational pharmaceutics and Pharma 4.0 to assist non-specialist readers Covering introductory, advanced, and specialist topics, Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 is an invaluable resource for computational chemists, computational analysts, pharmaceutical chemists, process engineers, process managers, and pharmacologists, as well as computer scientists, medicinal chemists, clinical pharmacists, material scientists, and nanotechnology specialists working in the field.

Some of the most original and productive research specialists in the field of particle-fluid flow systems are assembled in this book, which is an important and current reference volume. The book focuses on methods of measurement and options for engineers

Advances in Nanofluid Heat Transfer covers the broad definitions, brief history, preparation techniques, thermophysical properties, heat transfer characteristics, and emerging applications of hybrid nanofluids. Starting with the basics, this book advances step-by-step toward advanced topics, with mathematical models, schematic diagrams and discussions of the experimental work of leading researchers. By introducing readers to new techniques, this book helps readers resolve existing problems and implement nanofluids in innovative new applications. This book provides detailed coverage of stability and reliable measurement techniques for nanofluid properties, as well as different kinds of base fluids. Providing a clear understanding of what happens at the nanoscale, the book is written to be used by engineers in industry as well as researchers and graduate students. - Covers new applications of nanofluids, along with key challenges encountered in the commercialization of this technology - Highlights new nanofluid properties and associated numerical modeling methods - Addresses the very latest topics in nanofluids sciences, such as ionic nanofluids