The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.

The most comprehensive, single-volume guide to conductingexperiments with mixtures "If one is involved, or heavily interested, in experiments onmixtures of ingredients, one must obtain this book. It is, as wasthe first edition, the definitive work." -Short Book Reviews (Publication of the International StatisticalInstitute) "The text contains many examples with worked solutions and with itsextensive coverage of the subject matter will prove invaluable tothose in the industrial and educational sectors whose work involvesthe design and analysis of mixture experiments." -Journal of the Royal Statistical Society "The author has done a great job in presenting the vitalinformation on experiments with mixtures in a lucid and readablestyle. . . . A very informative, interesting, and useful book on animportant statistical topic." -Zentralblatt fur Mathematik und Ihre Grenzgebiete Experiments with Mixtures shows researchers and students how todesign and set up mixture experiments, then analyze the data anddraw inferences from the results. Virtually every technique thathas appeared in the literature of mixtures can be found here, andcomputing formulas for each method are provided with completelyworked examples. Almost all of the numerical examples are takenfrom real experiments. Coverage begins with Scheffe latticedesigns, introducing the use of independent variables, and endswith the most current methods. New material includes: * Multiple response cases * Residuals and least-squares estimates * Categories of components: Mixtures of mixtures * Fixed as well as variable values for the major componentproportions * Leverage and the Hat Matrix * Fitting a slack-variable model * Estimating components of variances in a mixed model using ANOVAtable entries * Clarification of blocking mates and choice of mates * Optimizing several responses simultaneously * Biplots for multiple responses

Praise for the Third Edition “. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences. Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes: Marginal and random effect models for analyzing correlated censored or uncensored data Multiple types of two-sample and K-sample comparison analysis Updated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of the presented material Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.

This book is based on the authors' significant practical experience partnering with scientists to develop strategies to accelerate the formulation (mixtures) development process. The authors not only explain the most important methods used to design and analyze formulation experiments, but they also present overall strategies to enhance both the efficiency and effectiveness of the development process.

Praise for the Second Edition “This book should be an essential part of the personal library of every practicing statistician.”—Technometrics Thoroughly revised and updated, the new edition of Nonparametric Statistical Methods includes additional modern topics and procedures, more practical data sets, and new problems from real-life situations. The book continues to emphasize the importance of nonparametric methods as a significant branch of modern statistics and equips readers with the conceptual and technical skills necessary to select and apply the appropriate procedures for any given situation. Written by leading statisticians, Nonparametric Statistical Methods, Third Edition provides readers with crucial nonparametric techniques in a variety of settings, emphasizing the assumptions underlying the methods. The book provides an extensive array of examples that clearly illustrate how to use nonparametric approaches for handling one- or two-sample location and dispersion problems, dichotomous data, and one-way and two-way layout problems. In addition, the Third Edition features: The use of the freely available R software to aid in computation and simulation, including many new R programs written explicitly for this new edition New chapters that address density estimation, wavelets, smoothing, ranked set sampling, and Bayesian nonparametrics Problems that illustrate examples from agricultural science, astronomy, biology, criminology, education, engineering, environmental science, geology, home economics, medicine, oceanography, physics, psychology, sociology, and space science Nonparametric Statistical Methods, Third Edition is an excellent reference for applied statisticians and practitioners who seek a review of nonparametric methods and their relevant applications. The book is also an ideal textbook for upper-undergraduate and first-year graduate courses in applied nonparametric statistics.

Praise for the First Edition "This...novel and highly stimulating book, which emphasizes solving real problems...should be widely read. It will have a positive and lasting effect on the teaching of modeling and statistics in general." - Short Book Reviews This new edition features developments and real-world examples that showcase essential empirical modeling techniques Successful empirical model building is founded on the relationship between data and approximate representations of the real systems that generated that data. As a result, it is essential for researchers who construct these models to possess the special skills and techniques for producing results that are insightful, reliable, and useful. Empirical Model Building: Data, Models, and Reality, Second Edition presents a hands-on approach to the basic principles of empirical model building through a shrewd mixture of differential equations, computer-intensive methods, and data. The book outlines both classical and new approaches and incorporates numerous real-world statistical problems that illustrate modeling approaches that are applicable to a broad range of audiences, including applied statisticians and practicing engineers and scientists. The book continues to review models of growth and decay, systems where competition and interaction add to the complextiy of the model while discussing both classical and non-classical data analysis methods. This Second Edition now features further coverage of momentum based investing practices and resampling techniques, showcasing their importance and expediency in the real world. The author provides applications of empirical modeling, such as computer modeling of the AIDS epidemic to explain why North America has most of the AIDS cases in the First World and data-based strategies that allow individual investors to build their own investment portfolios. Throughout the book, computer-based analysis is emphasized and newly added and updated exercises allow readers to test their comprehension of the presented material. Empirical Model Building, Second Edition is a suitable book for modeling courses at the upper-undergraduate and graduate levels. It is also an excellent reference for applied statisticians and researchers who carry out quantitative modeling in their everyday work.

A vivid, hands-on discussion of the statistical methods in imaging, optics, and photonics applications In the field of imaging science, there is a growing need for students and practitioners to be equipped with the necessary knowledge and tools to carry out quantitative analysis of data. Providing a self-contained approach that is not too heavily statistical in nature, Statistics for Imaging, Optics, and Photonics presents necessary analytical techniques in the context of real examples from various areas within the field, including remote sensing, color science, printing, and astronomy. Bridging the gap between imaging, optics, photonics, and statistical data analysis, the author uniquely concentrates on statistical inference, providing a wide range of relevant methods. Brief introductions to key probabilistic terms are provided at the beginning of the book in order to present the notation used, followed by discussions on multivariate techniques such as: Linear regression models, vector and matrix algebra, and random vectors and matrices Multivariate statistical inference, including inferences about both mean vectors and covariance matrices Principal components analysis Canonical correlation analysis Discrimination and classification analysis for two or more populations and spatial smoothing Cluster analysis, including similarity and dissimilarity measures and hierarchical and nonhierarchical clustering methods Intuitive and geometric understanding of concepts is emphasized, and all examples are relatively simple and include background explanations. Computational results and graphs are presented using the freely available R software, and can be replicated by using a variety of software packages. Throughout the book, problem sets and solutions contain partial numerical results, allowing readers to confirm the accuracy of their approach; and a related website features additional resources including the book's datasets and figures. Statistics for Imaging, Optics, and Photonics is an excellent book for courses on multivariate statistics for imaging science, optics, and photonics at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for professionals working in imaging, optics, and photonics who carry out data analyses in their everyday work.

Praise for the Second Edition "This book has never had a competitor. It is the only book that takes a broad approach to sampling . . . any good personal statistics library should include a copy of this book." —Technometrics "Well-written . . . an excellent book on an important subject. Highly recommended." —Choice "An ideal reference for scientific researchers and other professionals who use sampling." —Zentralblatt Math Features new developments in the field combined with all aspects of obtaining, interpreting, and using sample data Sampling provides an up-to-date treatment of both classical and modern sampling design and estimation methods, along with sampling methods for rare, clustered, and hard-to-detect populations. This Third Edition retains the general organization of the two previous editions, but incorporates extensive new material—sections, exercises, and examples—throughout. Inside, readers will find all-new approaches to explain the various techniques in the book; new figures to assist in better visualizing and comprehending underlying concepts such as the different sampling strategies; computing notes for sample selection, calculation of estimates, and simulations; and more. Organized into six sections, the book covers basic sampling, from simple random to unequal probability sampling; the use of auxiliary data with ratio and regression estimation; sufficient data, model, and design in practical sampling; useful designs such as stratified, cluster and systematic, multistage, double and network sampling; detectability methods for elusive populations; spatial sampling; and adaptive sampling designs. Featuring a broad range of topics, Sampling, Third Edition serves as a valuable reference on useful sampling and estimation methods for researchers in various fields of study, including biostatistics, ecology, and the health sciences. The book is also ideal for courses on statistical sampling at the upper-undergraduate and graduate levels.

Learn the science of collecting information to make effective decisions Everyday decisions are made without the benefit of accurate information. Optimal Learning develops the needed principles for gathering information to make decisions, especially when collecting information is time-consuming and expensive. Designed for readers with an elementary background in probability and statistics, the book presents effective and practical policies illustrated in a wide range of applications, from energy, homeland security, and transportation to engineering, health, and business. This book covers the fundamental dimensions of a learning problem and presents a simple method for testing and comparing policies for learning. Special attention is given to the knowledge gradient policy and its use with a wide range of belief models, including lookup table and parametric and for online and offline problems. Three sections develop ideas with increasing levels of sophistication: Fundamentals explores fundamental topics, including adaptive learning, ranking and selection, the knowledge gradient, and bandit problems Extensions and Applications features coverage of linear belief models, subset selection models, scalar function optimization, optimal bidding, and stopping problems Advanced Topics explores complex methods including simulation optimization, active learning in mathematical programming, and optimal continuous measurements Each chapter identifies a specific learning problem, presents the related, practical algorithms for implementation, and concludes with numerous exercises. A related website features additional applications and downloadable software, including MATLAB and the Optimal Learning Calculator, a spreadsheet-based package that provides an introduction to learning and a variety of policies for learning.

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.