In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

The Guinea Pigs is a chilling fable about dehumanization and alienation representing Vaculik's vision of the menace of Soviet domination in the wake of the 1969 invasion. Written in 1970, it is a sweeping condemnation of totalitarianism, embedded in a rich, imaginative, highly experimental narrative. In the words of the New York Review of Books it is "one of the major works of literature produced in postwar Europe."

Sam wants a pet for her birthday, but her mom and dad have already said that their apartment is too small for a cat or a dog. A trip to Rainbow Street Shelter to look at the smaller animals can't hurt, though! At the shelter, Sam finds the perfect pet for her, a fluffy black guinea pig named Henry. But she can't help noticing how happy her little brother is when he's reading to Nelly, the Rainbow Street dog. Why can't he read like that when he's in school? Nelly looks happy, too. Sam starts to wonder . . . can a dog go to kindergarten?

As the drive to integrate indigenous peoples into the modern global market economy becomes a priority with Latin American governments, the implementation of new economic policies regulating guinea pig husbandry is aggressively changing traditions and values in the Andes.

Answers to unusual questions, using mathematics. First two questions, as examples: How many birds would it take to pick you up and fly with you?; and, How many bees does it take to make one jar of honey?

When the vast wartime factories of the Manhattan Project began producing plutonium in quantities never before seen on earth, scientists working on the top-secret bomb-building program grew apprehensive. Fearful that plutonium might cause a cancer epidemic among workers and desperate to learn more about what it could do to the human body, the Manhattan Project's medical doctors embarked upon an experiment in which eighteen unsuspecting patients in hospital wards throughout the country were secretly injected with the cancer-causing substance. Most of these patients would go to their graves without ever knowing what had been done to them. Now, in The Plutonium Files, Pulitzer Prize-winning reporter Eileen Welsome reveals for the first time the breadth of the extraordinary fifty-year cover-up surrounding the plutonium injections, as well as the deceitful nature of thousands of other experiments conducted on American citizens in the postwar years. Welsome's remarkable investigation spans the 1930s to the 1990s and draws upon hundreds of newly declassified documents and other primary sources to disclose this shadowy chapter in American history. She gives a voice to such innocents as Helen Hutchison, a young woman who entered a prenatal clinic in Nashville for a routine checkup and was instead given a radioactive "cocktail" to drink; Gordon Shattuck, one of several boys at a state school for the developmentally disabled in Massachusetts who was fed radioactive oatmeal for breakfast; and Maude Jacobs, a Cincinnati woman suffering from cancer and subjected to an experimental radiation treatment designed to help military planners learn how to win a nuclear war. Welsome also tells the stories of the scientists themselves, many of whom learned the ways of secrecy on the Manhattan Project. Among them are Stafford Warren, a grand figure whose bravado masked a cunning intelligence; Joseph Hamilton, who felt he was immune to the dangers of radiation only to suffer later from a fatal leukemia; and physician Louis Hempelmann, one of the most enthusiastic supporters of the plan to inject humans with potentially carcinogenic doses of plutonium. Hidden discussions of fifty years past are reconstructed here, wherein trusted government officials debated the ethical and legal implications of the experiments, demolishing forever the argument that these studies took place in a less enlightened era. Powered by her groundbreaking reportage and singular narrative gifts, Eileen Welsome has created a work of profound humanity as well as major historical significance. From the Hardcover edition.

Offers information for the first-time pet owner on the physical characteristics, selection, care, and feeding of guinea pigs.

The bestselling “master of the medical thriller” (The New York Times) confronts one of the most compelling issues of our time: personality-altering drugs and the complex moral questions they raise. When neuroscientist Edward Armstrong begins dating Kimberly Stewart, a descendant of a woman who was hanged as a witch at the time of the Salem witch trials, he takes advantage of the opportunity to delve into a pet theory: that the “devil” in Salem in 1692 had been a hallucinogenic drug inadvertently consumed with mold-tainted grain. In an attempt to prove his theory, Edward grows the mold he believes responsible with samples from the Stewart estate. In a brilliant designer-drug transformation, the poison becomes Ultra, the next generation of antidepressants with truly startling therapeutic capabilties. But who can be sure the drug is safe for consumers? Who defines the boundaries of “normal” human behavior? And if the drug’s side effects are proven to be dangerous—even terrifying—how far will the medical community go to alter their standards of acceptable risk?

The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.