The XXII Texas Symposium on Relativistic Astrophysics, jointly organized by the Kavli Institute for Particle Astrophysics and Cosmology (KIPAC), the Stanford Linear Accelerator Center, and the Physics Department of Stanford University, was held on December 13-17, 2004. Following the tradition of past Texas Symposia the presentations emphasized recent developments in Cosmology, High Energy Astrophysics and the frontiers between these and Gravitation and Particle Physics. This Symposium was attended by more than 500 colleagues from a spectrum of disciplines mentioned above. There were 9 Plenary Sessions, 3 Parallel Sessions and 2 Poster Sessions held during the five-day program, with 76 oral and 240 poster presentations. These are now documented on CD and in the eConf proceedings archive. Funding of $15,000 received from the DOE under award DE-FG02-05ER41362 was used for expenses related to facility, local transportation and administrative expenses.