In September 2015, the National Academies of Sciences, Engineering, and Medicine convened a two-day workshop on evolving paradigms for design and manufacturing. Participants discussed ways to lower costs and shorten production time in defense systems while bringing materials and manufacturing alternatives into the tradespace. This publication summarizes the presentations and discussions from the workshop.

In September 2015, the National Academies of Sciences, Engineering, and Medicine convened a two-day workshop on evolving paradigms for design and manufacturing. Participants discussed ways to lower costs and shorten production time in defense systems while bringing materials and manufacturing alternatives into the tradespace. This publication summarizes the presentations and discussions from the workshop.

"In September 2015, the National Academies of Sciences, Engineering, and Medicine convened a two-day workshop on evolving paradigms for design and manufacturing. Participants discussed ways to lower costs and shorten production time in defense systems while bringing materials and manufacturing alternatives into the tradespace. This publication summarizes the presentations and discussions from the workshop"--Publisher's description

Industrial Environmental Performance Metrics is a corporate-focused analysis that brings clarity and practicality to the complex issues of environmental metrics in industry. The book examines the metrics implications to businesses as their responsibilities expand beyond the factory gateâ€"upstream to suppliers and downstream to products and services. It examines implications that arise from greater demand for comparability of metrics among businesses by the investment community and environmental interest groups. The controversy over what sustainable development means for businesses is also addressed. Industrial Environmental Performance Metrics identifies the most useful metrics based on case studies from four industriesâ€"automotive, chemical, electronics, and pulp and paperâ€"and includes specific corporate examples. It contains goals and recommendations for public and private sector players interested in encouraging the broader use of metrics to improve industrial environmental performance and those interested in addressing the tough issues of prioritization, weighting of metrics for meaningful comparability, and the longer term metrics needs presented by sustainable development.

Research libraries have engaged in publishing activities in the past, but recently there has been intense growth in the number of library publishing services supporting faculty and students. Unified by a commitment to both access and service, library publishing programs have grown from an early focus on backlist digitization to publication of student works, textbooks, and research data. This growing engagement with publishing is a natural and research data. This growing engagement with publishing is a natural extension of the academic library's commitment to support the creation of and access to scholarship. Getting the Word Out examines the growing trend in library publishing with 11 chapters by some of the most talented thinkers in the field. Edited by library publishing experts Maria Bonn, of the University of Illinois Urbana-Champaign Graduate School of Library and Information Science, and Mike Furlough, HathiTrust Digital Library, this book deepens current discussions in the field, and provides decision makers and practitioners with an introduction to the state of the field with an eye towards future prospects. -- from back cover.

This fourth edition of the book provides readers with a detailed explanation of PLM, enabling them to gain a full understanding and the know-how to implement PLM within their own business environment. This new and expanded edition has been fully updated to reflect the numerous technological and management advances made in PLM since the release of the third edition in 2014, including chapters on both the Internet of Things and Industry 4.0. The book describes the environment in which products are ideated, developed, manufactured, supported and retired before addressing the main components of PLM and PLM Initiatives. These include product-related business processes, product data, product data management (PDM) systems, other PLM applications, best practices, company objectives and organisation. Key activities in PLM Initiatives include Organisational Change Management (OCM) and Project Management. Lastly, it addresses the PLM Initiative, showing the typical steps and activities of a PLM project or initiative. Enhancing readers’ understanding of PLM, the book enables them to develop the skills needed to implement PLM successfully and achieve world-class product performance across the lifecycle.

Written by twenty-five authors from academia, pharmaceutical industry and Pharmacopeias worldwide, this monograph covers the fundamentals and applications of Quality by Design (QbD) and Analytical Quality by Design (AQbD) in a practical and didactic manner. The book starts by describing the motivation and the urgent need for the implementation of the QbD framework in pharmaceutical development, along with the definition of its major elements: Quality Target Product Profile (QTTP), Critical Quality Attributes (CQAs), Critical Process Parameters (CPPs), Critical Material Attributes (CMAs) and the importance of using multivariate methods of Design of Experiments (DOE). The concept of life cycle and regulatory perspectives are discussed. Three chapters are entirely dedicated to DOE theory from screening to optimization designs. Moreover, a comprehensive discussion on modelling and data treatment is presented. Practical aspects of QbD and DOE for pharmaceutical product and process of different dosage forms is included, as well as a practical guide of the input process variables, material attributes, intermediate, and final quality attributes for the most representative pharmaceutical processes. Analytical Quality by Design (AQbD) is also deeply explored, including risk analysis, definitions of Analytical Target Profile (ATP), Method Operable Design Region (MODR) and the life cycle approach, taking into account the compendial and regulatory perspectives. A detailed example of a new chromatographic method for the quality control of a pharmaceutical topical product based on the AQbD procedure is shown. Finally, advanced statistical approaches and DOE methods for extraction studies of bioactive compounds are also presented. The vast amount of information offered in this book provides a comprehensive perspective on QbD, AQbD and DOE principles, essential tools for modern pharmaceutical and analytical development.

Collected here are 112 papers concerned with all manner of new directions in manufacturing systems given at the 41st CIRP Conference on Manufacturing Systems. The high-quality material presented in this volume includes reports of work from both scientific and engineering standpoints and several invited and keynote papers addressing the current cutting edge and likely future trends in manufacturing systems. The book’s subjects include: (1) new trends in manufacturing systems design: sustainable design, ubiquitous manufacturing, emergent synthesis, service engineering, value creation, cost engineering, human and social aspects of manufacturing, etc.; (2) new applications for manufacturing systems – medical, life-science, optics, NEMS, etc.; (3) intelligent use of advanced methods and new materials – new manufacturing process technologies, high-hardness materials, bio-medical materials, etc.; (4) integration and control for new machines – compound machine tools, rapid prototyping, printing process integration, etc.

The fourth edition of the Handbook of Human Factors and Ergonomics has been completely revised and updated. This includes all existing third edition chapters plus new chapters written to cover new areas. These include the following subjects: Managing low-back disorder risk in the workplace Online interactivity Neuroergonomics Office ergonomics Social networking HF&E in motor vehicle transportation User requirements Human factors and ergonomics in aviation Human factors in ambient intelligent environments As with the earlier editions, the main purpose of this handbook is to serve the needs of the human factors and ergonomics researchers, practitioners, and graduate students. Each chapter has a strong theory and scientific base, but is heavily focused on real world applications. As such, a significant number of case studies, examples, figures, and tables are included to aid in the understanding and application of the material covered.