This volume contains the proceedings of the 1st EMBS Special Topic Conference on Microtechnology in Medicine & Biology. The papers discuss: biocompatibility and biosurface microengineering; micro fluidics; single cell analysis; clinical medicine; biomimetics; micro instrumentation; and more.

Present Your Research to the World! The World Congress 2009 on Medical Physics and Biomedical Engineering – the triennial scientific meeting of the IUPESM - is the world’s leading forum for presenting the results of current scientific work in health-related physics and technologies to an international audience. With more than 2,800 presentations it will be the biggest conference in the fields of Medical Physics and Biomedical Engineering in 2009! Medical physics, biomedical engineering and bioengineering have been driving forces of innovation and progress in medicine and healthcare over the past two decades. As new key technologies arise with significant potential to open new options in diagnostics and therapeutics, it is a multidisciplinary task to evaluate their benefit for medicine and healthcare with respect to the quality of performance and therapeutic output. Covering key aspects such as information and communication technologies, micro- and nanosystems, optics and biotechnology, the congress will serve as an inter- and multidisciplinary platform that brings together people from basic research, R&D, industry and medical application to discuss these issues. As a major event for science, medicine and technology the congress provides a comprehensive overview and in–depth, first-hand information on new developments, advanced technologies and current and future applications. With this Final Program we would like to give you an overview of the dimension of the congress and invite you to join us in Munich! Olaf Dössel Congress President Wolfgang C.

We humans are tribal, grouping ourselves by a multitude of criteria: physical, intellectual, political, emotional, etc. The Internet and its auxiliary technologies have enabled a novel dimension in tribal behavior during our recent past. This growing connectivity begs the question: will individuals and their communities come together to solve some very urgent global problems? At MMVR, we explore ways to harness information technology to solve healthcare problems - and in the industrialized nations we are making progress. In the developing world however, things are more challenging. Massive urban poverty fuels violence and misery. Will global networking bring a convergence of individual and tribal problem-solving? Recently, a barrel-shaped water carrier that rolls along the ground was presented, improving daily life for many people. Also the One Laptop per Child project is a good example of how the industrialized nations can help the developing countries. They produce durable and simple laptops which are inexpensive to produce. At MMVR, we focus on cutting-edge medical technology, which is generally pretty expensive. While the benefits of innovation trickle downward, from the privileged few to the broader masses, we should expand this trickle into a flood. Can breakthrough applications in stimulation, visualization, robotics, and informatics engender tools as ingeniously as the water carrier or laptop? With some extra creativity, we can design better healthcare for the developing world too.

This book is based on the 13 review articles written by subject experts and published in 2014 in the Journal Reviews of Adhesion and Adhesives. The rationale for publication of this book is that currently the RAA has limited circulation, so this book provides broad exposure and dissemination of the concise, critical, illuminating, and thought-provoking review articles. The subjects of the reviews fall into 4 general areas: 1. Polymer surface modification 2. Biomedical, pharmaceutical and dental fields 3. Adhesives and adhesive joints 4. General Adhesion Aspects The topics covered include: Adhesion of condensed bodies at microscale; imparting adhesion property to silicone material; functionally graded adhesively bonded joints; synthetic adhesives for wood panels; adhesion theories in wood adhesive bonding; adhesion and surface issues in biocomposites and bionanocomposites; adhesion phenomena in pharmaceutical products and applications of AFM; cyanoacrylate adhesives in surgical applications; ways to generate monosort functionalized polyolefin surfaces; nano-enhanced adhesives; bonding dissimilar materials in dentistry; flame treatment of polymeric materials—relevance to adhesion; and mucoadhesive polymers for enhancing retention of ocular drug delivery.

This book provides a multidisciplinary overview of the design and implementation of systems for remote patient monitoring and healthcare. Readers are guided through the components of such a system and shown how they could be integrated into a coherent framework for deployment in practice. The book ends with a discussion of case studies to provide practical examples and design methods for remote healthcare systems with different needs. This book contains information that will be helpful to undergraduate and postgraduate students, academic and professional researchers, and individuals who employ computational intelligence. By presenting new models of care and support, AI in medicine is having an impact on the entire value chain of clinical practice and the patient care delivery system. This is especially evident in telemedicine breakthroughs, where applications of AI are utilized to assist, complement, or create new forms of remote healthcare. Through the use of communications technology, telemedicine enables medical professionals to examine, diagnose, and treat patients remotely. Now, the technology might also integrate online diagnostics, etc., to increase the effectiveness of the healthcare system and enhance patient outcomes. By enabling elderly people to live independently, technological advancements in fields like remote patient monitoring (RPM) systems can revolutionize senior care. Medical diagnosis will improve, and remote patient monitoring will become simpler thanks to artificial intelligence. The resistance of many patients and doctors to using the telemedicine idea for medical visits will probably be overcome by AI automation.

This book will describe ultra low-power, integrated circuits and systems designed for the emerging field of neural signal recording and processing, and wireless communication. Since neural interfaces are typically implanted, their operation is highly energy-constrained. This book introduces concepts and theory that allow circuit operation approaching the fundamental limits. Design examples and measurements of real systems are provided. The book will describe circuit designs for all of the critical components of a neural recording system, including: Amplifiers which utilize new techniques to improve the trade-off between good noise performance and low power consumption. Analog and mixed-signal circuits which implement signal processing tasks specific to the neural recording application: Detection of neural spikes Extraction of features that describe the spikes Clustering, a machine learning technique for sorting spikes Weak-inversion operation of analog-domain transistors, allowing processing circuits that reduce the requirements for analog-digital conversion and allow low system-level power consumption. Highly-integrated, sub-mW wireless transmitter designed for the Medical Implant Communications Service (MICS) and ISM bands.

The new generation of wearable personal eHealth systems has to be affordable, user-friendly, “invisible”, autonomous in terms of power consumption and able to assist individuals in their own health management. Major challenges are ahead such as further research and development, user acceptance and trust, cost-effectiveness and business models. Intelligent Biomedical Clothing and biomedical sensors are becoming major driving forces for cutting-edge developments. The synergy and close collaboration of all involved disciplines and sectors is of paramount importance. This book consists of papers describing developments and trends all over the world in the areas of smart wearable monitoring and diagnostic systems, smart treatment systems, biomedical clothing and smart fibres and fabrics. It covers also non-research aspects such as citizens and patients needs, interoperability, risk management and market perspectives. The chapters are preceded by a short executive summary which highlights the main issues, findings and conclusions for the convenience of the reader. The participation of the major actors involved in research, development, decision making and business should make this book unique and a pioneer in the field.

Lntegration, a new paradigm in analytical chemistry; Integration in science and technology; Integration in analytical chemistry; Partsand components; Supportedreagents; Separation membranes; Systems; Total analysis systems; Miniaturised systems; Networked systems; Sensors; Electrochemical sensors; Optochemical sensors; Arraysystems; Redundant-sensor array systems; Selective-sensor array systems; Cross-selective sensor array systems; Microsystems; Microsensors; Analytical microsystems; Array microsystems; Nanosystems; Conclusions and perspectives; lntegrated separation systems; General principIes ofbi-phase separation; Thermodynamics ofbi-phase equilibrium; Integration concepts in bi-phase separation; Integration of uptake and stripping steps; Multiplication of single separation effect; Frontal íon exchange chromatography; Reverse frontal íon exchange chromatography; Displacement chromatography; Tandem íon exchange fractionation; Combined separation techniques; Solvent extraction-ion exchange. Aqua impregnated resins; Ion exchange-crystallisation. Ion exchange isothermal supersaturation; Ion exchange supersaturation of zwitterlites; Ion exchange supersaturation of electrolytes; Solid-phase spectrometric assays; Integration of processes in solid-phase spectrometric assays; Types of solid-phase spectrometric assays; Features of solid-phase spectrometric assays; Particulated solid-phase spectrometric assays; Fixation process; Operational aspects; Analytical characteristics; Mixtures resolution; Analytical applications; Membrane solid-phase spectrometric assays; Membrane filtration systems; Membrane 'problem' equilibration systems; Membrane 'problem' deposit systems; Continuous flow analytical systems; Reverse flow injection; Integrating effect of conventional flow injection units; Confluencepoints; Exchangedunits; Modifiedunits; Duplicateunits; Derivatisation reactions in flow injection systems; Redox reactions involving solid reagents; Micellar media; Photoinduced reactions; Electrogenerated reagents; Catalytic reactions; External energy sources integrated with flow injection; Conventional heat sources; illtrasound energy sources; Use of electrical energy; Microwave energy assistance; In-line coupling of simple non-chromatographic continuous separation units and flow injection manifolds; Couplings with techniques involving gas-separation: gas-diffusers, pervaporators and others; Couplings with liquid-liquid separators: dialysers and liquid-liquid extractors; Couplingswith liquid-solid separators and solid phase formation; On-line separation equipment and flow injection manifolds; On-line coupling of robotics and flow injection manifolds; Detection in flow injection; Flow injection-detector interfaces; Automatic calibration; Special uses of conventional detectors coupled to FI; Three-dimensional and complex detectors coupled to FI; Screening and flow injection Integration and flow injection; Distributed analytical instrumentation systems; Theremoteconcept; Elements in a measurement system; Distributed systems topologies; Theremoteplace; The benefits of distributed intelligence; The computer-controlling function; Virtual instruments; Smart/intelligent sensors; The link; Industrial networks; Ethernet; Wireless links; The local place; Remote analytical instruments/systems: application examples; Laboratory information management systems; The analytical laboratory; Role of an analytical laboratory; Need to increase productivity; The aims oflaboratory automation; Problems with laboratory automation; Solutions for laboratory automation; What is laboratory automation?; A definition oflaboratory automation; Laboratory automation constituent groups; Instrument automation; Communications; Data to information conversion; Information management; A laboratory automation strategy in practice; Laboratory Information Management Systems; What is a LIMS?; A LIMS has two targets; Construction of the LIMS matrix; LIMS matrix views; Organisational integration and LIMS; LIMS and the system development life cycle; System development life cycle; Project proposal; The LIMS project team; User requirements specification and system selection; Functional specification; Qualification of the system; User training and roll-out strategies; Project close-out; Post-implementation review; Enhancement ofthe system and controlling change; Chemically modified electrodes with integrated biomolecules and molecular wires; Enzyme redox catalysis; Redox hydrogels; Self-assembled polyelectrolyte and protein films; Self-assembled enzyme films; Electrocatalysis; Electronhopping; Different molecular architectures; Structure ofself-assembled enzyme films; Atomic force microscopy; Ellipsometry; Combination of QCM and ellipsometric measurements; Infrared spectroscopy (FTIR); Composite and biocomposite materiais forelectrochemicalsensing; Composite electrode materiaIs; Conducting composite; Conducting biocomposites; Composite- and biocomposite-based electrochemical sensors; Conductometric sensors; Potentiometric sensors; Amperometric sensors; Thick-film sensors; Sensors for voltammetric stripping techniques; Optical chemical sensors and biosensor; Sensor structure; Optical fibers; Optoelectronic instrumentation; Molecular recognition element; Sensor designs; Modes of optical signal measurements; Absorbance measurement; Reflectance measurement; Fluorescence measurement; Chemiluminescence measurement; Electronic tongues: new analytical perspective of chemical sensors; General approach to the application of sensor arrays; Why use sensor systems?; Inspirations from chemometrics and biology; Advantages of sensor systems in comparlson with discrete sensors; Specific features of the sensors for the electronictongue; Electronic tongue systems; Sensors; System designs; Hybrid systems; Data processing; Selected applications ofthe electronic tongue; Application areas and analytes; Quantitative analysis; Qualitative analysis, recognition, identification andclassification; Comparison with human perception offlavours; Taste quantification; Application ofhybrid systems; Problems and perspective; A Taste sensor; Structure of the taste sensor; Response characteristics; Aminoacids; Classification oftaste ofamino acids; Discrimination of D-amino acids from L-aminoacids; Quantification ofthe taste of foods; Interaction between taste qualities; Suppression ofbitterness due to phospholipids; Scale ofbitterness; Suppression of bitterness due to taste substances; Detection of wine flavor using taste sensor and electronic nose; Perspective; Application of electronic nose technology for monitoring water and wastewater; Electronic nose technology; Sensor types; Analysis ofelectronic nose data; Electronic nose instrumentation; Sensor array components; Commercial systems; Application to water and wastewater monitoring; Laboratory-based systems; On-line monitoring systems; lntegrated optical transducers for (bio)chemical sensing; Basic concepts; Fundamentals of optical waveguides; Detection principIes: Types of devices; Technologies for integrated optical transducer fabrication; Substrate materiaIs and specific processes; Basic technological processes; Integrated optical sensors; Absorbancesensor; Gratingcoupler; Resonantmirror; Mach-Zehnder interferometer; Towards a total integrated system; High arder hybrid FET module for (bio)chemical andphysicalsensing; Design concepts of(bio)chemical sensor arrays; High arder sensor module based on an identical transducer principIe; Hybrid module design; ISFET fabrication; Measuring system and sensor configurations; Multi-parameter detection of both (bio)chemical and physical quantities using the same transducer principIe; ISFET-based pH sensor; ISFET-based penicillin sensor; ISFET-based temperature sensor; ISFET-based flow-velocity sensor; ISFET-based flow-direction sensor;ISFET-based diffusion-coefficient sensor; ISFET-based bioelectronic sensor; Applications of the hybrid sensor module; pH determination in human urine; pH measurement in rain droplets; Summary and conclusion; Microdialysis based lab-on-a-chip, applying a generic MEM Stechnology; The need for in vivo monitoring; Microdialysis; The microdialysis lab-on-a-chip; The micromachined double lumen microdialysis probe connector; The conventional microdialysis probe; Experimental; Results and discussion; The passive and the active calibration system; Passive contraI of a calibration plug; Active contraI of a calibration plug; Closed-loop controlled electrochemically actuated microdosing system; The flow-through potentiometric and amperometric sensor array; The flow-through potentiometric sensorarray; The flow-through reference electrode; The flow-through amperometric sensor; The integrated microdialysis-based lab-on-a-chip; The complete integrated microdialysis lab-on-a-chip; Measurements; Design methodology for a lab-on-a-chip for chemical analysis: the MAFIAS chip; The design path; The design; Chemistry; System schematics; Channel geometry; Specifications for the components; Thecomponents; Nanosensor and nanoprobe systems for in vivo bioanalysis; Background on biosensors and bioreceptors; Biosensing systems; Bioreceptor probes; Fiberoptics nanosensor system; Fabrication of the fiberoptic nanoprobe; Immobilization of receptors onto fiber nanoprobes; Experimental system and protocol for nanoprobe investigation of single cells; Optical measurement system; Applications in bioanalysis; Optical nanofiber probes for fluorescence measurements; Single-cell measurements using antibody-based nanoprobes.