Traditionally, fluid mixing and the related multiphase contacting processes have always been regarded as an empirical technology. Many aspects of mixing, dispersing and contacting were related to power draw, but understanding of the phenomena was limited or qualitative at the most. In particular during the last decade, however, plant operation targets have tightened and product specifications have become stricter. The public awareness as to safety and environmental hygiene has increased. The drive towards larger degrees of sustainability in the process industries has urged for lower amounts of solvents and for higher yields and higher selectivities in chemical reactors. All this has resulted in a market pull: the need for more detailed insights in flow phenomena and processes and for better verifiable design and operation methods. Developments in miniaturisation of sensors and circuits as well as in computer technology have rendered leaps possible in computer simulation and animation and in measuring and monitoring techniques. This volume encourages a leap forward in the field of mixing by the current, overwhelming wealth of sophisticated measuring and computational techniques. This leap may be made possible by modern instrumentation, signal and data analysis, field reconstruction algorithms, computational modelling techniques and numerical recipes.

Handbook of Industrial Mixing will explain the difference and uses of a variety of mixers including gear mixers, top entry mixers, side entry mixers, bottom entry mixers, on-line mixers, and submerged mixers The Handbook discusses the trade-offs among various mixers, concentrating on which might be considered for a particular process. Handbook of Industrial Mixing explains industrial mixers in a clear concise manner, and also: * Contains a CD-ROM with video clips showing different type of mixers in action and a overview of their uses. * Gives practical insights by the top professional in the field. * Details applications in key industries. * Provides the professional with information he did receive in school

Advances in Industrial Mixing is a companion volume and update to the Handbook of Industrial Mixing. The second volume fills in gaps for a number of industries that were not covered in the first edition. Significant changes in five of the fundamental areas are covered in entirely updated or new chapters. The original text is provided as a searchable pdf file on the accompanying USB. This book explains industrial mixers and mixing problems clearly and concisely. Gives practical insights by the top professionals in the field, combining industrial design standards with fundamental insight. Details applications in 14 key industries. Six of these are new since the first edition. Provides the professional with information he/she did not receive in school. Five completely rewritten chapters on mixing fundamentals where significant advances have happened since the first edition and seven concise update chapters which summarize critical technical information.

The theme of the present volume of Advances in Chemical Engineering is Computational Fluid Dynamics (CFD) and aims to show the state-of-the-art of the application of CFD in chemical engineering. The volume is made up of five complementary contributions, providing a style of between a tutorial and a research paper. Some contributions are entirely limited to velocity and temperature fields. Others emphasize the difficulties associated with the combination of transport and reaction. Contributions include dealing with the simulation of gas-liquid bubble columns and gas-liquid-solid fluidized beds. Addressing the different levels of modeling that are required in order to cover the full spectrum of length scales that are important for industrial applications. Stirred turbulent vessels and the chemical reactions. The importance of chemical reaction kinetics and the interaction with transport phenomena. Finally, looking at reactor engineering: the catalytic fixed bed reactor. - Original reviews - Leading chemical engineers as authors - Reviewing the state-of-the-art of Computational Fluid Dynamics (CFD)

The homogenization of single phase gases or liquids with chemical reactive components by mixing belongs to one of the oldest basic operations applied in chemical engineering. The mixing process is used as an essential step in nearly all processes of the chemical industry as well as the pharmaceutical and food ind- tries. Recent experimentally and theoretically based results from research work lead to a fairly good prediction of the velocity fields in differend kinds of mixers, where as predictions of simultaneously proceeding homogeneous chemical re- tions, are still not reliable in a similar way. Therefore the design of equipment for mixing processes is still derived from measurements of the so called “mixing time” which is related to the applied methods of measurement and the special - sign of the test equipment itself. The cooperation of 17 research groups was stimulated by improved modern methods for experimental research and visualization, for simulations and nume- cal calculations of mixing and chemical reactions in micro and macro scale of time and local coordinates. The research work was financed for a six years period within the recently finished Priority Program of the German Research Foundation (DFG) named “Analysis, modeling and numerical prediction of flow-mixig with and without chemical reactions (SPP 1141)”. The objective of the investigations was to improve the prediction of efficiencies and selectivities of chemical re- tions on macroscopic scale.

Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering.

"Multiphase flow and heat transfer have found a wide range of applications in several engineering and science fields such as mechanical engineering, chemical and petrochemical engineering, nuclear engineering, energy engineering, material engineering, ocea"

Multiphase Particulate Systems in Turbulent Flows: Fluid-Liquid and Solid-Liquid Dispersions provides methods necessary to analyze complex particulate systems and related phenomena including physical, chemical and mathematical description of fundamental processes influencing crystal size and shape, suspension rheology, interfacial area of drops and bubbles in extractors and bubble columns. Examples of mathematical model formulation for different processes taking place in such systems is shown. Discussing connections between turbulent mixing mechanisms and precipitation, it discusses influence of fine-scale structure of turbulence, including its intermittent character, on breakage of drops, bubbles, cells, plant cell aggregates. An important aspect of the mathematical modeling presented in the book is multi-fractal, taking into account the influence of internal intermittency on different phenomena. Key Features Provides detailed descriptions of dispersion processes in turbulent flow, interactions between dispersed entities, and continuous phase in a single volume Includes simulation models and validation experiments for liquid-liquid, gas-liquid, and solid-liquid dispersions in turbulent flows Helps reader learn formulation of mathematical models of breakage or aggregation processes using multifractal theory Explains how to solve different forms of population balance equations Presents a combination of theoretical and engineering approaches to particulate systems along with discussion of related diversity, with exercises and case studies

This book is a printed edition of the Special Issue Intermittency and Self-Organisation in Turbulence and Statistical Mechanics that was published in Entropy

A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying Presents updated and expanded example calculations Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industryf ocuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.