I am delighted to write a preface for this Celebratory eBook published in the Specialty Section Neuropharmacology, within the journal Frontiers in Pharmacology. The eBook delivers a compendium of high impact papers published previously in the journal over the last ten years; at the time of writing this collection of 20 papers has been viewed 700k times with over 75k downloads. Clearly this Section is delivering a useful resource to the scientific and medical research community! The scope of the Specialty Section Neuropharmacology is deliberately broad. We encourage submission of high quality and impactful papers in the field of neuropharmacology along the full length of the translational escalator; from cellular and molecular investigations to clinical trials. I believe this is a real strength of the Section and helps attract a diverse readership that builds the stakeholder network to promote further engagement of the Section with the research community. I have no doubt that this has contributed to the growth of the Section with submissions and accepted papers displaying 10-year (2009-2019) compound annual growth rates (CAGRs) of 58% and 78%, respectively. Vitaly, high quality, scientific rigour and impact are fundamental to a paper being accepted and this inevitably leads to a relatively high level of rejection, but the transparency of the review process means a fair decision is reached. Essential for the handling and considered review of submitted papers, the Specialty Section Neuropharmacology has a dynamic cohort of Associate Editors that have been selected carefully (81 at the time of writing) that represent the full spectrum of neuropharmacology as well as being widespread geographically around the globe. The Associate Editors are supported by nearly 500 Review Editors that ensures informed review – indeed the relatively open and interactive review process often adds considerably to the accepted version of the paper. As we celebrate the success of Frontiers in Pharmacology and the Specialty Section Neuropharmacology with this eBook, we must also recognise and be thankful for the hard work and dedication of those in the Editorial Office; their enthusiasm and willingness to help is outstanding and they form an integral component of the overall team that delivers the success. I look forward to further success for the Specialty Section Neuropharmacology. Happy reading! Professor Nicholas M. Barnes, FBPhS Specialty Chief Editor, Neuropharmacology

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

This textbook is intended to give an introduction to neuroscience for students and researchers with no biomedical background. Primarily written for psychologists, this volume is a digest giving a rapid but solid overview for people who want to inform themselves about the core fields and core concepts in neuroscience but don’t need so many anatomical or biochemical details given in “classical” textbooks for future doctors or biologists. It does not require any previous knowledge in basic science, such as physics or chemistry. On the other hand, it contains chapters that do go beyond the issues dealt with in most neuroscience textbooks: One chapter about mathematical modelling in neuroscience and another about “tools of neuroscience” explaining important methods. The book is divided in two parts. The first part presents core concepts in neuroscience: Electrical Signals in the Nervous System Basics of Neuropharmacology Neurotransmitters The second part presents an overview of the neuroscience fields of special interest for psychology: Clinical Neuropharmacology Inputs, Outputs and Multisensory Processing Neural Plasticity in Humans Mathematical Modeling in Neuroscience Subjective Experience and its Neural Basis The last chapter, “Tools of Neuroscience” presents important methodogical approaches in neuroscience with a special focus on brain imaging. Neuroscience for Psychologists aims to fill a gap in the teaching literature by providing an introductory text for psychology students that can also be used in other social sciences courses, as well as a complement in courses of neurophysiology, neuropharmacology or similar in careers outside as well as inside biological or medical fields. Students of data sciences, chemistry and physics as well as engineering interested in neuroscience will also profit from the text.

Essential Neuropharmacology: The Prescriber's Guide reviews the full range of medications used by neurologists in clinical practice. Expert knowledge is given about the best use of medications in patient care. Each drug listing contains the full range of indications, their advantages and disadvantages, and tips for dosing and avoiding adverse effects. Evidence is taken from recent clinical trials, which helps the reader relate the drug descriptions to everyday clinical practice. Where appropriate, off-label uses are also described. The detailed descriptions of each medication enable the user to make quick and informed decisions with the confidence they need to serve the clinical needs of their patients effectively. The new edition is fully updated throughout. Major new additions include neuro-oncology drugs, new multiple sclerosis agents, sleep medications and new formulations. This book is an essential, user-friendly reference suitable for neurologists at all stages of their careers.

Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Experimental and theoretical approaches to global brain dynamics that draw on the latest research in the field. The consideration of time or dynamics is fundamental for all aspects of mental activity—perception, cognition, and emotion—because the main feature of brain activity is the continuous change of the underlying brain states even in a constant environment. The application of nonlinear dynamics to the study of brain activity began to flourish in the 1990s when combined with empirical observations from modern morphological and physiological observations. This book offers perspectives on brain dynamics that draw on the latest advances in research in the field. It includes contributions from both theoreticians and experimentalists, offering an eclectic treatment of fundamental issues. Topics addressed range from experimental and computational approaches to transient brain dynamics to the free-energy principle as a global brain theory. The book concludes with a short but rigorous guide to modern nonlinear dynamics and their application to neural dynamics.

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

This is a spin-off from Stephen M. Stahl's new, completely revised and updated version of his much-acclaimed Prescriber's Guide, covering drugs to treat depression.