Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care. - Provides a comprehensive volume on the translation and implementation of biology into health care provision - Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation - Includes an up-to-date overview on major 'translational events' in genomic and personalized medicine, along with lessons learned

A masterwork of W. G. Sebald, now with a gorgeous new cover by the famed designer Peter Mendelsund The four long narratives in The Emigrants appear at first to be the straightforward biographies of four Germans in exile. Sebald reconstructs the lives of a painter, a doctor, an elementary-school teacher, and Great Uncle Ambrose. Following (literally) in their footsteps, the narrator retraces routes of exile which lead from Lithuania to London, from Munich to Manchester, from the South German provinces to Switzerland, France, New York, Constantinople, and Jerusalem. Along with memories, documents, and diaries of the Holocaust, he collects photographs—the enigmatic snapshots which stud The Emigrants and bring to mind family photo albums. Sebald combines precise documentary with fictional motifs, and as he puts the question to realism, the four stories merge into one unfathomable requiem.

"The book is like a dream you want to last forever" (Roberta Silman, The New York Times Book Review), now with a gorgeous new cover by the famed designer Peter Mendelsund A masterwork of W. G. Sebald, now with a gorgeous new cover by the famed designer Peter Mendelsund The Rings of Saturn—with its curious archive of photographs—records a walking tour of the eastern coast of England. A few of the things which cross the path and mind of its narrator (who both is and is not Sebald) are lonely eccentrics, Sir Thomas Browne’s skull, a matchstick model of the Temple of Jerusalem, recession-hit seaside towns, wooded hills, Joseph Conrad, Rembrandt’s "Anatomy Lesson," the natural history of the herring, the massive bombings of WWII, the dowager Empress Tzu Hsi, and the silk industry in Norwich. W.G. Sebald’s The Emigrants (New Directions, 1996) was hailed by Susan Sontag as an "astonishing masterpiece perfect while being unlike any book one has ever read." It was "one of the great books of the last few years," noted Michael Ondaatje, who now acclaims The Rings of Saturn "an even more inventive work than its predecessor, The Emigrants."

The novelist, poet, and essayist W. G. Sebald (1944 – 2001) was perhaps the most original German writer of the last decade of the 20th century (“Die Ausgewanderten”, “Austerlitz”, “Luftkrieg und Literatur”). His writing is marked by a unique ‘hybridity’ that combines characteristics of travelogue, cultural criticism, crime story, historical essay, and dream diary, among other genres. He employs layers of literary and motion picture allusions that contribute to a sometimes enigmatic, sometimes intimately familiar mood; his dominant mode is melancholy. The contributions of this anthology examine W. G. Sebald as narrator and pensive observer of history. The book includes a previously unpublished interview with Sebald from 1998.

A modern search for the greatest cricketer of all time on the centenary of his death

This volume provides a dissection of W.G. Sebald's fiction and his acclaim. A German writer who taught in England for 30 years, he published four novels, first in German and then in English. His work gained even greater acclaim after his death in 2001, just months after the publication of his title Austerlitz.

W. G. Sebald is widely acknowledged as one of the most significant writers to have emerged onto the global literary scene in recent decades, and is frequently mentioned in the same breath as Nabokov, Kafka, Borges, Calvino, Proust, and Primo Levi. W. G. Sebald-Image, Archive, Modernity offers a unique and original reading of Sebald's dazzling oeuvre, arguing that his work is concerned first and foremost with the problem of modernity. It focuses in particular on the numerous archival institutions and processes that lie at the very heart of modernity and are repeatedly thematised throughout Sebald's work.Adopting a broad definition of the archive to encompass a wide range of material practices, the book analyses the function of photography, museums, libraries, and other systems of knowledge to which Sebald's texts obsessively return. Following Foucault, such systems are seen as central to the exercise of power and the constitution of subjectivity in modernity. By undertaking a differentiated analysis that is attuned to the formal complexities of Sebald's texts, this book shows that Sebald's engagement with structures of power-knowledge is characterised by a melancholy struggle to assert autonomous selfhood in the face of the institutional and discursive determinants of subjectivity.

______________________ A fascinating examination of cricket in the nineteenth century by 'the most entertaining historian alive' (Spectator) 'Few historians have the power to make you feel you actually inhabit the times they are writing about. Kynaston does' Sunday Times, Books of the Decade On a hot morning in July 1898, the sporting world gathered at Lord's to celebrate the fiftieth birthday of WG Grace, the greatest cricketer the game has ever seen. Grace was cheered onto the field by a packed crowd as he captained the Gentlemen, the privileged old guard of the Establishment. Their opponents in this annual match were the Players, cricketers for whom the sport was a precarious livelihood rather than a summer pastime. This three-day encounter represented the climax of cricket's Golden Age, and the unstoppable arrival of the professional game that would dominate the twentieth century. In WG's Birthday Party, David Kynaston tells the story of one of the most thrilling matches in cricketing history, as well as the colourful and sometimes tragically moving lives of the members of both teams. Using the Gentlemen vs Players contest as a lens through which to examine the hierarchy and tensions endemic in cricket at the beginning of the modern era, he presents a lively, moving, richly detailed and massively entertaining portrait of late-Victorian society. It is social history at its most compelling, from 'the most entertaining historian alive'. ______________________ 'An absolute gem of a book' Guardian 'Kynaston writes brilliantly and readably' Independent on Sunday

This book offers a new critical perspective on the perpetual problem of literature's relationship to reality and in particular on the sustained tension between literature and historiography. The scholarly and literary works of W.G. Sebald (1944–2001) serve as striking examples for this discussion, for the way in which they demonstrate the emergence of a new hybrid discourse of literature as historiography. This book critically reconsiders the claims and aims of historiography by re-evaluating core questions of the literary discourse and by assessing the ethical imperative of literature in the 20th and 21st centuries. Guided by an inherently interdisciplinary framework, this book elucidates the interplay of epistemological, aesthetic, and ethical concerns that define Sebald's criticism and fiction. Appropriate to the way in which Sebald's works challenge us to rethink the boundaries between discourses, genres, disciplines, and media, this work proceeds in a methodologically non-dogmatic way, drawing on hermeneutics, semiotics, narratology, and discourse theory. In addition to contextualizing Sebald within postwar literature in German, the book is the first English-language study to consider Sebald's œuvre as a whole. Of interest for Sebald experts and enthusiasts, literary scholars and historians concerned with the problematic of representing the past.