This policy brief, one of two on the updated HCV guidelines, focuses on the new recommendations on simplified service delivery for a public health approach to HCV testing, care and treatment. These recommendations include decentralization, integration and task-sharing, in addition to the use of POC HCV viral load assays and reflex viral load testing. Simplified service delivery (decentralization, integration and task sharing): Expansion of HCV testing and treatment services, ideally at the same site, through decentralization of care to lower-level facilities; integration with existing services, such as in primary care, harm reduction programmes, prisons and HIV ervices; and promotion of task sharing through delivery of HCV testing, care and treatment by appropriately trained non-specialist doctors and nurses. HCV diagnostics – use of Point-of-care (POC) HCV RNA viral load and reflex HCV RNA viral load testing: The use of point-of-care (POC) HCV ribonucleic acid (RNA) assays is now recommended as an alternative approach to laboratory-based RNA assays to diagnose viraemic infection. This is especially applicable to marginalized populations, such as persons who inject drugs, and hard-to-reach communities with limited access to health care and high rates of loss to follow-up.

This policy brief focuses on the new recommendations on treatment of adolescents and children ages ≥3 years with chronic HCV infection. The new treatment recommendations that extend the 2018 “treat all” recommendation for adults with chronic HCV infection to include adolescents and children down to 3 years, and to align the existing recommended pangenotypic DAA regimens (SOF/DCV, SOF/VEL and G/P) for adults, to those for adolescents and children. This alignment is expected to simplify procurement, promote access to treatment among children in LMICs and contribute to global efforts to eliminate the disease.

The Consolidated guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations outline a public health response for five key populations (men who have sex with men, trans and gender diverse people, sex workers, people who inject drugs and people in prisons and other closed settings). They present and discuss new recommendations and consolidate a range of recommendations and guidance from current WHO guidelines. Particularly for key populations, social, legal, structural and other contextual factors both increase vulnerability to HIV, viral hepatitis and STIs and obstruct access to health and other essential services. These guidelines highlight the critical importance of addressing structural barriers in all settings as a priority. In most countries, inadequate coverage and poor quality of services for key populations continue to undermine responses to HIV, viral hepatitis and STIs. All countries should prioritise reaching key populations and supporting key population communities to lead the response and provide equitable, accessible and acceptable services. In most countries, inadequate coverage and poor quality of services for key populations continue to undermine responses to HIV, viral hepatitis and STIs. All countries should prioritise reaching these key populations and supporting key population communities to lead the response and provide equitable, accessible and acceptable services to these groups.

Hepatitis B (HBV) infection is a major public health problem and cause of chronic liver disease. The 2024 HBV guidelines provide updated evidence-informed recommendations on key priority topics. These include expanded and simplified treatment criteria for adults but now also for adolescents; expanded eligibility for antiviral prophylaxis for pregnant women to prevent mother-to-child transmission of HBV; improving HBV diagnostics through use of point-of-care HBV DNA viral load and reflex approaches to HBV DNA testing; who to test and how to test for HDV infection; and approaches to promote delivery of high-quality HBV services, including strategies to promote adherence to long-term antiviral therapy and retention in care. The 2024 guidelines include 11 updated chapters with new recommendations and also update existing chapters without new recommendations, such as those on treatment monitoring and surveillance for liver cancer.

This is the first consolidated WHO report on viral hepatitis epidemiology, service coverage and product access, with improved data for action. This report presents the latest estimates on the disease burden and the coverage of essential viral hepatitis services from 187 countries across the world. The report also updates progress made since 2019 in improving access to health products for both hepatitis B and C in low- and middle-income countries, with information from 38 countries that together comprise nearly 80% of global viral hepatitis infections and deaths. The report provides a regional perspective, analysing the barriers and opportunities for countries in each of the 6 WHO regions to expand access to health products for viral hepatitis. It presents actions for countries and stakeholders to accelerate the scaling up of effective viral hepatitis interventions within a public health approach.

WHO has progressively strengthened its work for adolescent health, growing its portfolio of research, norms and standards, country support and advocacy, and expanding the scope of work across over 17 departments, regional and country offices to address the multifaceted needs of the global adolescent population. Central to a coordinated approach to adolescent health across the organization is the HQ Interdepartmental Technical Working Group on Adolescent Health and Well-being. In 2021, the group produced the first report on its work on adolescent health and well-being, celebrating efforts across many areas of work and all levels of the organization. This is the second in the series of biennial reports that comes on the wake of the Global Forum for Adolescents 2023 and is powered by its 1.8 Billion Young People for Change campaign. The report describes WHO’s efforts to elevate adolescent health and well-being through collaboration and by coordinating new initiatives, addressing emerging needs and establishing ambitious objectives with its development partners and adolescents. Target audience: this WHO serial publication is designed to be used by policy-makers, media and donors.