This issue of Critical Care Clinics, guest edited by Dr. Janice L. Zimmerman, focuses on Toxicology. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Pharmacokinetic and pharmacodynamic principles for toxicology, Use of extracorporeal techniques in poisonings, Drugs of Abuse, Cardiovascular Drug Toxicity, Anticoagulant and Anti-platelet Drug Toxicity and Psychotropic Agents.

This issue of Critical Care Clinics, guest edited by Dr. Janice L. Zimmerman, focuses on Toxicology. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Pharmacokinetic and pharmacodynamic principles for toxicology, Use of extracorporeal techniques in poisonings, Drugs of Abuse, Cardiovascular Drug Toxicity, Anticoagulant and Anti-platelet Drug Toxicity and Psychotropic Agents.

Topics include: Cocaine intoxication, Carbon monoxide poisoning, Update on miscellaneous drug overdoses, T oxidromes, Cardiac glycoside toxicity, Acetaminophen overdose, Envenomations, Methanol and ethylene glycol ingestion, and Toxicologic causes of ketoacidosis.

In this issue of Emergency Medicine Clinics, guest editors Drs. Christopher P. Holstege and Joshua D. King bring their considerable expertise to the topic of Toxicology Emergencies. The field of medical toxicology has grown dramatically over the past decade, with the emergence of new pharmaceuticals, abused substances, chemicals within the workplace, and agents of terrorism. In this issue, top experts in the field address some of the more common, controversial, or emerging areas in this challenging area. - Contains 15 relevant, practice-oriented topics including the approach to the patient with an unknown overdose; emerging agents of substance abuse and misuse; differentiating the causes of metabolic acidosis in the poisoned patient; pediatric toxicology; and more. - Provides in-depth clinical reviews on toxicology emergencies, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Critical Care Clinics, guest edited by Drs. Michael Matthay and Kathleen Dori Lui, focuses on Acute Respiratory Distress Syndrome. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Epidemiology, Environmental Factors, Clinical Diagnosis, Physiology of ARDS, including COVID-19, Pathogenesis Based on Clinical Studies, Genetics of ARDS, Ventilator Management and Rescue Therapy with ECMO, Acute Kidney Injury and ARDS, Pharmacologic Therapies and ARDS and Long Term Outcomes from ARDS. - Provides in-depth, clinical reviews on ARDS, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Critical Care Clinics, guest editors Drs. Lori Shutter and Deepa Malaiyandi bring their considerable expertise to the topic of Neurocritical Care, a rapidly growing specialty of complex care. Top experts in the field provide up-to-date articles on important clinical trials and evidence-based care of the critically ill patient with neurological injury. Contains 16 practice-oriented topics including current management of acute ischemic stroke; status epilepticus: a neurological emergency; neurotrauma and ICP management; neuropharmacology in the ICU; artificial intelligence and big data science in neurocritical care; and more. Provides in-depth clinical reviews on neurocritical care, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Topics include: Cocaine intoxication, Carbon monoxide poisoning, Update on miscellaneous drug overdoses, Toxidromes, Cardiac glycoside toxicity, Acetaminophen overdose, Envenomations, Methanol and ethylene glycol ingestion, and Toxicologic causes of ketoacidosis.

In this issue of Critical Care Clinics, guest editors Drs. Robert M. Kliegman and Brett J. Bordini bring their considerable expertise to the topic of Undiagnosed and Rare Diseases in Critical Care. Top experts in the field cover key topics such as critical genetic arrhythmia disorders, uncommon causes of rhabdomyolysis, status epilepsy syndromes, autoimmune encephalitis, rapid-onset paralysis and weakness, and more. - Contains 17 relevant, practice-oriented topics including understanding cognitive diagnostic errors in the ICU; rapid WES/WGS in the ICU; diagnostic time-outs to improve diagnosis; when "sepsis is not sepsis: MAS, HLH, malignancies and other sepsis mimics; all that wheezes is not asthma or bronchiolitis; and more. - Provides in-depth clinical reviews on undiagnosed and rare diseases in critical care, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Section 1 General Management of Poisoning or Overdose 1. Approach to Unknown Poisoning 2. Laboratory Tests in Poisoning 3. Acid Base Disorders in Poisoning 4. Antidotes. 5. Lipid Emulsion Therapy in the Management of Acute Poisonings 6. Understanding Forensic Toxicology for the Critical Care Specialist Section 2 Drugs of Abuse 7. Central Nervous System Depressants: Overdose And Management 8. Sympathomimetic Drugs. 9. Cocaine 10. Newer Drugs of Abuse. Section 3 CNS Toxins 11. Toxin induced seizures. 12. Toxic Alcohols 13. Botulism. 14. Anticonvulsant Overdose Section 4 Pulmonary Toxins 15. Approach to Respiratory Failure 16. Inhalation Poisoning 17. Carbon Monoxide Poisoning Section 5 Cardiac Toxins 18. Approach to Patient with 19. Aluminum Phosphide 20. Beta-blocker and Calcium Channel Blocker Overdose 21. Sodium channel blockers: TCA, serotonin, and anti-histamines 22. Digoxin and Other Cardiac Glycosides Section 6 Gastrointestinal and Liver Toxins 23. Acetaminophen (Paracetamol) Poisoning. 24. Nsaid Overdose 25. Corrosive Ingestion: Acids and Alkalis Section 7 Hematological Toxins 26. Warfarin and Superwarfarin Toxicity 27. Overdose of Newer Anticoagulants. 28. Dyshemoglobinemias Section 8 Renal toxins and Extracorporeal Therapies 29.Approach to Toxin Induced Acute Renal Failure. 30. Extracorporeal Therapies in the Management of Acute Poisoning: Specific Poisons. 31.Extra Corporeal Toxin Removal: General Principles. 32. Extracorporeal Membrane Oxygenation Section 9 Pesticides and Rodenticides 33. Management of Organophosphate Poisoning. 34. Carbamates and Newer Insecticides 35. Herbicide Poisoning (Paraquat and Diquat 36. Organochlorine Pesticides. 37. Rodenticide Poisoning Section 10 Miscellaneous Toxicities 38. Heavy Metal Poisoning 39. Envenomation 40. Plant Poisoning In India 41. Mushroom poisoning 42. Methotrexate and Other Chemotherapeutic Agents Toxicity. 43. Metformin and other oral hypoglycemic agents 44. Chemical and Biological Warfare. Index

This issue of Critical Care Clinics, Guest Edited by Dr. Stephen M. Pastores and Dr. Wendy R. Greene, focuses on Critical Care of the Cancer Patient (Pastores) and Geriatric Critical Care (Greene). Dr. Pastores' section of the issue is devoted to Critical Care of the Cancer Patient and includes the following topics: Triage and Prognostication of Cancer Patients Admitted to the ICU; ICU Organization and Interdisciplinary Care for Critically Ill Patients with Cancer; Critical Care of the Hematopoietic Stem Cell Transplant Recipient; Management of Drug Toxicities; Acute Kidney Injury in the Critically Ill Patient with Cancer; Infectious Disease Complications in Cancer Patients; and Palliative, Ethics, and End-of-Life Care Issues in the Cancer Patient. Dr. Green's section of the issue, devoted to Geriatric Critical Care, includes the following topics: The effect of aging physiology on critical care; The frailty syndrome: a critical issue in geriatric oncology; Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratings; Evidence-based geriatric nursing protocols for best practice; The effect of dementia in the critically ill geriatric patient; Nutritional assessment: a primary component of multidimensional geriatric assessment in the ICU; Rehabilitation concerns in the geriatric critically ill and injured; and Geriatric palliative care.