Splines provide a significant tool for the design of computationally economical curves and surfaces for the construction of various objects like automobiles, ship hulls, airplane fuselages and wings, propeller blades, shoe insoles, bottles, etc. It also contributes in the description of geological, physical, statistical, and even medical phenomena. Spline methods have proven to be indispensable in a variety of modern industries, including computer vision, robotics, signal and image processing, visualization, textile, graphic designs, and even media. This book aims to provide a valuable source on splines and their applications. It focuses on collecting and disseminating information in various disciplines including computer-aided geometric design, computer graphics, data visualization, data fitting, power systems, clinical and epidemiologic studies, disease detection, regression curves, social media, and biological studies. The book is useful for researchers, scientists, practitioners, and many others who seek state-of-the-art techniques and applications using splines. It is also useful for undergraduate senior students as well as graduate students in the areas of computer science, engineering, health science, statistics, and mathematics. Each chapter also provides useful information on software developments and their extensions.

The Theory of Splines and Their Applications discusses spline theory, the theory of cubic splines, polynomial splines of higher degree, generalized splines, doubly cubic splines, and two-dimensional generalized splines. The book explains the equations of the spline, procedures for applications of the spline, convergence properties, equal-interval splines, and special formulas for numerical differentiation or integration. The text explores the intrinsic properties of cubic splines including the Hilbert space interpretation, transformations defined by a mesh, and some connections with space technology concerning the payload of a rocket. The book also discusses the theory of polynomial splines of odd degree which can be approached through algebraically (which depends primarily on the examination in detail of the linear system of equations defining the spline). The theory can also be approached intrinsically (which exploits the consequences of basic integral relations existing between functions and approximating spline functions). The text also considers the second integral relation, raising the order of convergence, and the limits on the order of convergence. The book will prove useful for mathematicians, physicist, engineers, or academicians in the field of technology and applied mathematics.

A general class of powerful and flexible modeling techniques, spline smoothing has attracted a great deal of research attention in recent years and has been widely used in many application areas, from medicine to economics. Smoothing Splines: Methods and Applications covers basic smoothing spline models, including polynomial, periodic, spherical, t

In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: With Applications in R provides a full treatment of random effects joint models for longitudinal and time-to-event outcomes that can be utilized to analyze such data. The content is primarily explanatory, focusing on applications of joint modeling, but sufficient mathematical details are provided to facilitate understanding of the key features of these models. All illustrations put forward can be implemented in the R programming language via the freely available package JM written by the author. All the R code used in the book is available at: http://jmr.r-forge.r-project.org/

A spline is a thin flexible strip composed of a material such as bamboo or steel that can be bent to pass through or near given points in the plane, or in 3-space in a smooth manner. Mechanical engineers and drafting specialists find such (physical) splines useful in designing and in drawing plans for a wide variety of objects, such as for hulls of boats or for the bodies of automobiles where smooth curves need to be specified. These days, physi cal splines are largely replaced by computer software that can compute the desired curves (with appropriate encouragment). The same mathematical ideas used for computing "spline" curves can be extended to allow us to compute "spline" surfaces. The application ofthese mathematical ideas is rather widespread. Spline functions are central to computer graphics disciplines. Spline curves and surfaces are used in computer graphics renderings for both real and imagi nary objects. Computer-aided-design (CAD) systems depend on algorithms for computing spline functions, and splines are used in numerical analysis and statistics. Thus the construction of movies and computer games trav els side-by-side with the art of automobile design, sail construction, and architecture; and statisticians and applied mathematicians use splines as everyday computational tools, often divorced from graphic images.

This book serves well as an introduction into the more theoretical aspects of the use of spline models. It develops a theory and practice for the estimation of functions from noisy data on functionals. The simplest example is the estimation of a smooth curve, given noisy observations on a finite number of its values. Convergence properties, data based smoothing parameter selection, confidence intervals, and numerical methods are established which are appropriate to a number of problems within this framework. Methods for including side conditions and other prior information in solving ill posed inverse problems are provided. Data which involves samples of random variables with Gaussian, Poisson, binomial, and other distributions are treated in a unified optimization context. Experimental design questions, i.e., which functionals should be observed, are studied in a general context. Extensions to distributed parameter system identification problems are made by considering implicitly defined functionals.

The purpose of this book is to give a comprehensive introduction to the theory of spline functions, together with some applications to various fields, emphasizing the significance of the relationship between the general theory and its applications. At the same time, the goal of the book is also to provide new ma terial on spline function theory, as well as a fresh look at old results, being written for people interested in research, as well as for those who are interested in applications. The theory of spline functions and their applications is a relatively recent field of applied mathematics. In the last 50 years, spline function theory has undergone a won derful development with many new directions appearing during this time. This book has its origins in the wish to adequately describe this development from the notion of 'spline' introduced by 1. J. Schoenberg (1901-1990) in 1946, to the newest recent theories of 'spline wavelets' or 'spline fractals'. Isolated facts about the functions now called 'splines' can be found in the papers of L. Euler, A. Lebesgue, G. Birkhoff, J.

One of the clearest available introductions to variational methods, this text requires only a minimal background in linear algebra and analysis. It explains the application of theoretic notions to the kinds of physical problems that engineers regularly encounter. Many helpful definitions, examples, and exercises appear throughout the book. 1975 edition.

B-splines are fundamental to approximation and data fitting, geometric modeling, automated manufacturing, computer graphics, and numerical simulation. With an emphasis on key results and methods that are most widely used in practice, this textbook provides a unified introduction to the basic components of B-spline theory: approximation methods (mathematics), modeling techniques (engineering), and geometric algorithms (computer science). A supplemental Web site will provide a collection of problems, some with solutions, slides for use in lectures, and programs with demos.

Nonparametric function estimation with stochastic data, otherwise known as smoothing, has been studied by several generations of statisticians. Assisted by the ample computing power in today's servers, desktops, and laptops, smoothing methods have been finding their ways into everyday data analysis by practitioners. While scores of methods have proved successful for univariate smoothing, ones practical in multivariate settings number far less. Smoothing spline ANOVA models are a versatile family of smoothing methods derived through roughness penalties, that are suitable for both univariate and multivariate problems. In this book, the author presents a treatise on penalty smoothing under a unified framework. Methods are developed for (i) regression with Gaussian and non-Gaussian responses as well as with censored lifetime data; (ii) density and conditional density estimation under a variety of sampling schemes; and (iii) hazard rate estimation with censored life time data and covariates. The unifying themes are the general penalized likelihood method and the construction of multivariate models with built-in ANOVA decompositions. Extensive discussions are devoted to model construction, smoothing parameter selection, computation, and asymptotic convergence. Most of the computational and data analytical tools discussed in the book are implemented in R, an open-source platform for statistical computing and graphics. Suites of functions are embodied in the R package gss, and are illustrated throughout the book using simulated and real data examples. This monograph will be useful as a reference work for researchers in theoretical and applied statistics as well as for those in other related disciplines. It can also be used as a text for graduate level courses on the subject. Most of the materials are accessible to a second year graduate student with a good training in calculus and linear algebra and working knowledge in basic statistical inferences such as linear models and maximum likelihood estimates.