This book summarizes the current knowledge on a cascade of gene regulation levels which operate in the cytoplasm of eukaryotic cells and which has until recently been poorly understood. While transcriptional control of eukaryotic genes has been extensively researched and the understanding of this process has reached very sophisticated levels, post- transcriptional control has received much less attention. As the contributions in this book demonstrate, not only is post-transcriptional control in eukaryotes better understood, it is now thought to be a major player in gene expression control in a number of key processes, i.e. control of cell proliferation, gametogenesis and early development or cellular homeostasis.

This book demonstrates service-oriented architecture (SOA) as a concrete discipline rather than a hopeful collection of cloud charts. Built upon the author's firsthand experience rolling out a SOA at a major corporation, SOA in Practice explains how SOA can simplify the creation and maintenance of large-scale applications. Whether your project involves a large set of Web Services-based components, or connects legacy applications to modern business processes, this book clarifies how -- and whether -- SOA fits your needs. SOA has been a vision for years. This book brings it down to earth by describing the real-world problems of implementing and running a SOA in practice. After defining SOA's many facets, examining typical use patterns, and exploring how loose coupling helps build stronger applications, SOA in Practice presents a framework to help you determine when to take advantage of SOA. In this book you will: Focus squarely on real deployment and technology, not just standards maps Examine business problems to determine which ones fit a SOA approach before plastering a SOA solution on top of them Find clear paths for building solutions without getting trapped in the mire of changing web services details Gain the experience of a systems analyst intimately involved with SOA "The principles and experiences described in this book played an important role in making SOA at T-Mobile a success story, with more than 10 million service calls per day." --Dr. Steffen Roehn, Member of the Executive Committee T-Mobile International (CIO) "Nicolai Josuttis has produced something that is rare in the over-hyped world of SOA; a thoughtful work with deep insights based on hands-on experiences. This book is a significant milestone in promoting practical disciplines for all SOA practitioners." --John Schmidt, Chairman, Integration Consortium "The book belongs in the hands of every CIO, IT Director and IT planning manager." --Dr. Richard Mark Soley, Chairman and CEO, Object Management Group; Executive Director, SOA Consortium

Learning to build distributed systems is hard, especially if they are large scale. It's not that there is a lack of information out there. You can find academic papers, engineering blogs, and even books on the subject. The problem is that the available information is spread out all over the place, and if you were to put it on a spectrum from theory to practice, you would find a lot of material at the two ends but not much in the middle. That is why I decided to write a book that brings together the core theoretical and practical concepts of distributed systems so that you don't have to spend hours connecting the dots. This book will guide you through the fundamentals of large-scale distributed systems, with just enough details and external references to dive deeper. This is the guide I wished existed when I first started out, based on my experience building large distributed systems that scale to millions of requests per second and billions of devices. If you are a developer working on the backend of web or mobile applications (or would like to be!), this book is for you. When building distributed applications, you need to be familiar with the network stack, data consistency models, scalability and reliability patterns, observability best practices, and much more. Although you can build applications without knowing much of that, you will end up spending hours debugging and re-architecting them, learning hard lessons that you could have acquired in a much faster and less painful way. However, if you have several years of experience designing and building highly available and fault-tolerant applications that scale to millions of users, this book might not be for you. As an expert, you are likely looking for depth rather than breadth, and this book focuses more on the latter since it would be impossible to cover the field otherwise. The second edition is a complete rewrite of the previous edition. Every page of the first edition has been reviewed and where appropriate reworked, with new topics covered for the first time.

This classroom-tested textbook describes the design and implementation of software for distributed real-time systems, using a bottom-up approach. The text addresses common challenges faced in software projects involving real-time systems, and presents a novel method for simply and effectively performing all of the software engineering steps. Each chapter opens with a discussion of the core concepts, together with a review of the relevant methods and available software. This is then followed with a description of the implementation of the concepts in a sample kernel, complete with executable code. Topics and features: introduces the fundamentals of real-time systems, including real-time architecture and distributed real-time systems; presents a focus on the real-time operating system, covering the concepts of task, memory, and input/output management; provides a detailed step-by-step construction of a real-time operating system kernel, which is then used to test various higher level implementations; describes periodic and aperiodic scheduling, resource management, and distributed scheduling; reviews the process of application design from high-level design methods to low-level details of design and implementation; surveys real-time programming languages and fault tolerance techniques; includes end-of-chapter review questions, extensive C code, numerous examples, and a case study implementing the methods in real-world applications; supplies additional material at an associated website. Requiring only a basic background in computer architecture and operating systems, this practically-oriented work is an invaluable study aid for senior undergraduate and graduate-level students of electrical and computer engineering, and computer science. The text will also serve as a useful general reference for researchers interested in real-time systems.

A comprehensive guide to distributed algorithms that emphasizes examples and exercises rather than mathematical argumentation.

Cloud Computing: Theory and Practice provides students and IT professionals with an in-depth analysis of the cloud from the ground up. Beginning with a discussion of parallel computing and architectures and distributed systems, the book turns to contemporary cloud infrastructures, how they are being deployed at leading companies such as Amazon, Google and Apple, and how they can be applied in fields such as healthcare, banking and science. The volume also examines how to successfully deploy a cloud application across the enterprise using virtualization, resource management and the right amount of networking support, including content delivery networks and storage area networks. Developers will find a complete introduction to application development provided on a variety of platforms. - Learn about recent trends in cloud computing in critical areas such as: resource management, security, energy consumption, ethics, and complex systems - Get a detailed hands-on set of practical recipes that help simplify the deployment of a cloud based system for practical use of computing clouds along with an in-depth discussion of several projects - Understand the evolution of cloud computing and why the cloud computing paradigm has a better chance to succeed than previous efforts in large-scale distributed computing

Distributed Programming: Theory and Practice presents a practical and rigorous method to develop distributed programs that correctly implement their specifications. The method also covers how to write specifications and how to use them. Numerous examples such as bounded buffers, distributed locks, message-passing services, and distributed termination detection illustrate the method. Larger examples include data transfer protocols, distributed shared memory, and TCP network sockets. Distributed Programming: Theory and Practice bridges the gap between books that focus on specific concurrent programming languages and books that focus on distributed algorithms. Programs are written in a "real-life" programming notation, along the lines of Java and Python with explicit instantiation of threads and programs. Students and programmers will see these as programs and not "merely" algorithms in pseudo-code. The programs implement interesting algorithms and solve problems that are large enough to serve as projects in programming classes and software engineering classes. Exercises and examples are included at the end of each chapter with on-line access to the solutions. Distributed Programming: Theory and Practice is designed as an advanced-level text book for students in computer science and electrical engineering. Programmers, software engineers and researchers working in this field will also find this book useful.

Distributed Systems: An Algorithmic Approach, Second Edition provides a balanced and straightforward treatment of the underlying theory and practical applications of distributed computing. As in the previous version, the language is kept as unobscured as possible—clarity is given priority over mathematical formalism. This easily digestible text: Features significant updates that mirror the phenomenal growth of distributed systems Explores new topics related to peer-to-peer and social networks Includes fresh exercises, examples, and case studies Supplying a solid understanding of the key principles of distributed computing and their relationship to real-world applications, Distributed Systems: An Algorithmic Approach, Second Edition makes both an ideal textbook and a handy professional reference.

Doreen Galli uses her considerable academic and professional experience to bring together the worlds of theory and practice providing leading edge solutions to tomorrow's challenges. "Distributed Operating Systems: Concepts and Practice" offers a good balance of real world examples and the underlying theory of distributed computing. The flexible design makes it usable for students, practitioners and corporate training. This book describes in detail each major aspect of distributed operating systems from a conceptual and practical viewpoint. The operating systems of Amoeba, Clouds, and Chorus(TM) (the base technology for JavaOS(TM)) are utilized as examples throughout the text; while the technologies of Windows 2000(TM), CORBA(TM), DCOM(TM), NFS, LDAP, X.500, Kerberos, RSA(TM), DES, SSH, and NTP demonstrate real life solutions. A simple client/server application is included in the appendix to demonstrate key distributed computing programming concepts. This book proves invaluable as a course text or as a reference book for those who wish to update and enhance their knowledge base. A Companion Website provides supplemental information. A broad range of distributed computing issues and concepts: Kernels, IPC, memory management, object-based operating systems, distributed file systems (with NFS and X.500), transaction management, process management, distributed synchronization, and distributed security A major case study of Windows 2000 to demonstrate a real life commercial solution Detail Boxes contain in-depth examples such as complex algorithms Project-oriented exercises providing hands-on-experience Relevant sources including 'core' Web and ftp sites, as well as research papers Easy reference with complete list of acronyms and glossary to aid readability

An introduction to fundamental theories of concurrent computation and associated programming languages for developing distributed and mobile computing systems. Starting from the premise that understanding the foundations of concurrent programming is key to developing distributed computing systems, this book first presents the fundamental theories of concurrent computing and then introduces the programming languages that help develop distributed computing systems at a high level of abstraction. The major theories of concurrent computation—including the π-calculus, the actor model, the join calculus, and mobile ambients—are explained with a focus on how they help design and reason about distributed and mobile computing systems. The book then presents programming languages that follow the theoretical models already described, including Pict, SALSA, and JoCaml. The parallel structure of the chapters in both part one (theory) and part two (practice) enable the reader not only to compare the different theories but also to see clearly how a programming language supports a theoretical model. The book is unique in bridging the gap between the theory and the practice of programming distributed computing systems. It can be used as a textbook for graduate and advanced undergraduate students in computer science or as a reference for researchers in the area of programming technology for distributed computing. By presenting theory first, the book allows readers to focus on the essential components of concurrency, distribution, and mobility without getting bogged down in syntactic details of specific programming languages. Once the theory is understood, the practical part of implementing a system in an actual programming language becomes much easier.