What justifies the size of this compendium of reviews on the paramyxoviruses? As intracellular parasites that reproduce with almost complete indifference to nuclear activities, paramyxoviruses have not been providing insights about genes that regulate cellular activities and development, topics that account for much of the excitement in modem biology. For contributions of virus research to those topics, we must look to the retroviruses, which have the propensity to steal developmentally important genes and subvert them to malignant pur poses, and to the nuclear DNA viruses, whose gene expression depends heavily upon cellular transcription machinery, making them exceptionally useful tools for identifying and characterizing components of that machinery. From this perspective, it may appear that purely lytic viruses like the paramyxoviruses are sitting on the sidelines of contemporary biology. But there is plenty of action on the sidelines. Paramyxoviruses remain unconquered, devastating agents of disease. Human deaths attributable to paramyxoviruses worldwide, especially in children, are numbered in the mil lions annually. There are many pathogenic paramyxoviruses and too few effec tive vaccines, and those vaccines (against measles and mumps) are affordable only by relatively affluent nations. Moreover, the paramyxoviruses are intrin sically interesting organisms, presenting the challenge of understanding the self-replication of RNA and many other challenges peculiar to the structures and functions of their proteins, not only as individual entities, but also as they act in concert during virus reproduction and interact with vital functions of the cells they infect and often (but not always) destroy.

Provides a fully revised Eleventh Edition of the definitive reference to swine health and disease Diseases of Swine has been the definitive reference on swine health and disease for over 60 years. This new edition has been completely revised to include the latest information, developments, and research in the field. Now with full color images throughout, this comprehensive and authoritative resource has been redesigned for improved consistency and readability, with a reorganized format for more intuitive access to information. Diseases of Swine covers a wide range of essential topics on swine production, health, and management, with contributions from more than 100 of the foremost international experts in the field. This revised edition makes the information easy to find and includes expanded information on welfare and behavior. A key reference for anyone involved in the swine industry, Diseases of Swine, Eleventh Edition: Presents a thorough revision to the gold-standard reference on pig health and disease Features full color images throughout the book Includes information on the most current advances in the field Provides comprehensive information on swine welfare and behavior Offers a reorganized format to make the information more accessible Written for veterinarians, academicians, students, and individuals and agencies responsible for swine health and public health, Diseases of Swine, Eleventh Edition is an essential guide to swine health. "The 11th edition of Diseases of Swine continues to serve as the gold-standard resource for anything and everything related to swine herd health...this edition does an outstanding job of keeping up with the advanced diagnostic technologies and the latest research on new or emerging diseases and syndromes...there is no other informational resource that comes close to providing the depth or quality of information on the topic of swine diseases as does this book"

The knowledge and practice of clinical virology continues to expand. This new fifth edition has thirty-six comprehensive chapters, each of which has been extensively revised or rewritten, with the addition of new colour plates. This updated version takes into account knowledge accumulated in molecular biology with its applications for laboratory diagnosis, immunisation and antiviral chemotherapy. Each chapter highlights the clinical features and epidemiological patterns of infection. Similarly, in response to the global concern of the threat posed by new viruses, a new chapter on Emerging Infections is included. There is also new material on Hospital Acquired Infections, including some advice relating to SARS, that will be of benefit to those dealing with the day-to-day management of patients in hospital.

Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. - Features updated and expanded coverage of pathogenesis and immunity - Contains the latest laboratory diagnostic methods - Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

The most complete and definitive reference to all aspects of poultry diseases, Diseases of Poultry, Fourteenth Edition has been fully revised and updated to offer a comprehensive survey of current knowledge. Updates the definitive reference of poultry health and disease Provides more clinically relevant information on management of specific diseases, contributed by clinical poultry veterinarians Offers information on disease control in organic and antibiotic-free production Presents more concise, streamlined chapters for ease of use Incorporates advances in the field, from new diagnostic tools and information to changes brought about by the increasing globalization and the re-emergence of zoonotic pathogens

Approximately 75% of emerging infectious diseases are zoonoses, and the rate of emergence of zoonotic diseases is on the rise. Bats are being increasingly recognised as an important reservoir of zoonotic viruses of different families, including SARS coronavirus, Nipah virus, Hendra virus and Ebola virus. Understanding bats’ role in emerging zoonotic diseases is crucial to this rapidly expanding area of research. Bats and Viruses: A New Frontier of Emerging Infectious Diseases provides an updated overview of research focusing on bat biology and the role bats play as hosts of many major zoonotic viruses. The text covers bat biology, immunology, and genomics. Chapters also delve into the various major bat-borne virus families, including lyssaviruses, paramyxoviruses, coronaviruses, filoviruses and reoviruses, among others. Edited by leaders in the field, Bats and Viruses: A New Frontier of Emerging Infectious Diseases is a timely, invaluable reference for bat researchers studying microbiology, virology and immunology, as well as infectious disease workers and epidemiologists, among others.

This book provides a timely and comprehensive review of current knowledge of all paramyxoviruses and is written by renowned scientists who have made seminal contributions in their respective paramyxovirus fields of expertise. Topics include: mumps virus, simian virus 5, parainfluenza viruses, Newcastle disease and related avian paramyxoviruses, Sendai virus, Hendra virus, Nipah virus, measles virus, canine distemper virus, rinderpest virus, peste des petits ruminants virus, human respiratory syncytial virus, metapneumoviruses, and new and emerging paramyxoviruses. Each chapter covers our curre.

The essential reference of clinical virology Virology is one of the most dynamic and rapidly changing fields of clinical medicine. For example, sequencing techniques from human specimens have identified numerous new members of several virus families, including new polyomaviruses, orthomyxoviruses, and bunyaviruses. Clinical Virology, Fourth Edition, has been extensively revised and updated to incorporate the latest developments and relevant research. Chapters written by internationally recognized experts cover novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, organized into two major sections: Section 1 provides information regarding broad topics in virology, including immune responses, vaccinology, laboratory diagnosis, principles of antiviral therapy, and detailed considerations of important organ system manifestations and syndromes caused by viral infections. Section 2 provides overviews of specific etiologic agents and discusses their biology, epidemiology, pathogenesis of disease causation, clinical manifestations, laboratory diagnosis, and management. Clinical Virology provides the critical information scientists and health care professionals require about all aspects of this rapidly evolving field.

An important resource that reviews the various infectious diseases that affect bats and bat populations Bats and Human Health: Ebola, SARS, Rabies and Beyond covers existing literature on viral, bacterial, protozoan, and fungal infections of bats and how these infections affect bat populations. The book also offers an overview of the potential for zoonotic transmission of infectious diseases from bats to humans or domestic animals. While most prior publications on the subject have dealt only with bat viral infections, this text closely covers a wide range of bat infections, from viral and bacterial infections to protist and fungal infections. Chapters on viral infections cover rabies, filoviruses, henipaviruses, and other RNA viruses, as well as information on bat virome studies. The book then provides information on bacterial infections–including arthropod-borne and other bacteria that affect bats–before moving on to protist infections, including apicomplexans and kinetoplastids, and fungal infections, including white-nose syndrome, histoplasma capsulatum, and other fungi. Comprehensive in scope, yet another key feature of this book is a searchable database that includes bat species, bat family, bat diet, bat location, type and classification of infecting microbes, and categories of microbes. This vital resource also: Provides a history and comprehensive overview of bat-borne diseases Incorporates information from the World Health Organization, as well as historical data from the National Libraries of Health and infectious disease journals Covers a variety of diseases including viral infections, bacterial infections, protist infections, and fungal infections Written for microbiologist, bat researchers, and conservationists, Bats and Human Health provides a comprehensive exploration of the various types of microbes that affect bats and their potential to affect human populations.

also occurs. New outbreaks of yellow fever have occurred in Colombia and Trinidad and new outbreaks of rift valley fever have occurred in Egypt. Chapter 6, Arenaviruses: The biochemical and physical properties have now been clar ified, and they show a remarkable uniformity in the various viruses constituting the group. The possibility that prenatal infection with LCM may result in hydrocephalus and chorioretinitis has been raised. Serologic surveys have suggested the existence of Lassa virus infection in Guinea, Central African Empire, Mali, Senegal, Cameroon, and Benin, in addition to earlier identification in Nigeria, Liberia, and Sierra Leone. Chapter 7, Coronaviruses: New studies have confirmed the important role of these viruses in common respiratory illnesses of children and adults. The viruses are now known to contain a single positive strand of RNA. About 50% of corona virus infections result in clinical illness. About 5% of common colds are caused by strain DC 43 in winter. Chapter 8, Cytomegalovirus: Sections on pathogenesis of CMV in relation to organ transplantation and mononucleosis, as well as sections on the risk and features of con genital infection and disease, have been expanded. There are encouraging preliminary results with a live CMV vaccine, but the questions of viral persistence and oncogenicity require further evaluation.