'This book is pretty life-changing – encouraging, optimistic, rich with information. It got me off the sofa.' Jeremy Vine 'This is such a lovely, ambitious, fascinating book. Essential lockdown reading. It allows us to reimagine our world and our bodies: we can move more.' Dr Xand van Tulleken, TV presenter 'Truly uplifting' Chris Boardman What is the 'miracle pill', the simple lifestyle change with such enormous health benefits that, if it was turned into a drug, would be the most valuable drug in the world? The answer is movement and the good news is that it's free, easy and available to everyone. Four in ten British adults, and 80% of children, are so sedentary they don’t meet even the minimum recommended levels for movement. What’s going on? The answer is simple: activity became exercise. What for centuries was universal and everyday has become the fetishised pursuit of a minority, whether the superhuman feats of elite athletes, or a chore slotted into busy schedules. Yes, most people know physical activity is good for us. And yet 1.5 billion people around the world are so inactive they are at greater risk of everything from heart disease to diabetes, cancer, arthritis and depression, even dementia. Sedentary living now kills more people than obesity, despite receiving much less attention, and is causing a pandemic of chronic ill health many experts predict could soon bankrupt the NHS. How did we get here? Daily, constant exertion was an integral part of humanity for millennia, but in just a few decades movement was virtually designed out of people’s lives through transformed workplaces, the dominance of the car, and a built environment which encourages people to be static. In a world now also infiltrated by ubiquitous screens, app-summoned taxis and shopping delivered to your door, it can be shocking to realise exactly how sedentary many of us are. A recent study found almost half of middle-aged English people don’t walk continuously for ten minutes or more in an average month. At current trends, scientists forecast, the average US adult will expend little more energy in an average week than someone who spent all their time in bed. This book is a chronicle of this very modern and largely unexplored catastrophe, and the story of the people trying to turn it around. Through interviews with experts in various fields - doctors, scientists, architects and politicians - Peter Walker explores how to bring more movement into the modern world and, most importantly, into your life. Forget the gym, introducing quick and easy lifestyle changes can slow down the ageing process and even reverse many illnesses and increase mental wellbeing.

What if there were a drug to treat every illness, across all body systems, proven potent against heart disease, depression, arthritis, PMS and erectile dysfunction—even in chronic diseases such as asthma, dementia, and certain types of cancer? What if it had no side effects, was completely free, readily available, and worked for everyone? Every single person who took it decreased her risk of premature death and raised his quality of life. Would you want it? In a healthcare system that spends 17% of GDP, roughly $2.7 trillion, mostly on disease treatment, how do we save money and prevent illness? By increasing the use of the world's most effective preventive medicine: exercise. Jordan D. Metzl, MD, explains how everyone can maximize their daily dose in his groundbreaking new book, The Exercise Cure. In The Exercise Cure, Dr. Metzl—nationally renowned sports medicine physician—offers malady-specific and well-researched exercise prescriptions to help readers stay healthy, heal disease, drop pounds, increase longevity, and transform their lives. Today's medical system is largely focused on fixing rather than preventing problems, and many treatments carry significant side effects. Cholesterol-lowering drugs are linked to frequent muscle and joint problems, anti-hypertensive drugs like Beta-blockers cause headaches and diminished energy, and Prozac and other popular anti-depressant medications carry multiple consequences including sexual dysfunction. Dr. Metzl knows that exercise is inexpensive, powerful medicine that has benefits in prevention and treatment of disease without disturbing side effects. Even in older adults, daily exercise has been found to prevent dementia by generating neuron development in the hippocampus, the memory center of the brain. Combining the latest data and his proven motivational skills, Dr. Metzl addresses the common maladies troubling millions. He discusses our cardiovascular, pulmonary, metabolic, musculoskeletal, neurologic, reproductive, and endocrinologic body systems, with special sections on sleep problems and cancer prevention, presenting the science behind the role of exercise as medicine. Then, he details fun, fat-torching, life-prolonging workouts that can be tailored easily to any fitness level, beginner to advanced, and provides nutritional information, including meal plans for healthy eating and disease prevention, as well.

A Chicago Tribune "Best Books of 2014" • A Slate "Best Books 2014: Staff Picks" • A St. Louis Post-Dispatch "Best Books of 2014" The fascinating story of one of the most important scientific discoveries of the twentieth century. We know it simply as "the pill," yet its genesis was anything but simple. Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic; the visionary scientist Gregory Pincus, who was dismissed by Harvard in the 1930s as a result of his experimentation with in vitro fertilization but who, after he was approached by Sanger and McCormick, grew obsessed with the idea of inventing a drug that could stop ovulation; and the telegenic John Rock, a Catholic doctor from Boston who battled his own church to become an enormously effective advocate in the effort to win public approval for the drug that would be marketed by Searle as Enovid. Spanning the years from Sanger’s heady Greenwich Village days in the early twentieth century to trial tests in Puerto Rico in the 1950s to the cusp of the sexual revolution in the 1960s, this is a grand story of radical feminist politics, scientific ingenuity, establishment opposition, and, ultimately, a sea change in social attitudes. Brilliantly researched and briskly written, The Birth of the Pill is gripping social, cultural, and scientific history.

History of the breakthrough of the cancer pill "Gleevec."

Miracle drug or deal with the devil? After forty years of marriage, Jill and Don Stegman had it all—two beautiful children, a stable relationship, fulfilling careers. But a brush with cancer and subsequent complications upended their lives. Don survived the cancer but was saddled with a sinister sidekick that transformed this gentle Dr. Jekyll into an evil Mr. Hyde: a white pill called prednisone. What was supposed to save him instead killed him—by his own hand. With 44 million prescriptions written per year, for everything from allergies to immune system disorders, prednisone is something of a miracle drug. But the side effects—mania, psychosis, depression—took Don's life and nearly ruined Jill's. In the months and years after Don's death, Jill reels from grief but finds her own way of coping. A memoir written in beautiful prose, One Pill Makes You Stronger is a love story, a cautionary tale, and a true testament to human resilience.

To the millions of Americans who suffer from chronic pain and arthritis, Vioxx seemed like a miracle. One of the most widely promoted and prescribed pain medications in the world -- used by more than twenty million people -- it was endorsed by the medical establishment and celebrities such as Olympic champion figure skater Dorothy Hamill. With annual sales of $2.5 billion, Vioxx became a pharmaceutical bonanza before being abruptly taken off the market in September 2004, after it was revealed that it led to an increased risk of heart-related disease and death. Drawing on internal documents, video footage, court testimony, and exclusive interviews, as well as three decades of experience inside the medical industry, Tom Nesi tells the dramatic story of what the drug's manufacturer, Merck, knew and when. It is a compelling narrative of business and medical science run amok, with a cast of characters ranging from those at the highest levels of the multibillion-dollar pharmaceutical industry to research scientists, marketers, and drug company sales reps. Here also are accounts from physicians, lawyers, financial analysts, and patients and their families whose lives have been forever altered by Vioxx. Set against a fascinating history of the origins of the modern pharmaceutical industry, POISON PILLS is a shocking tale that involves the breakdown of the United States medical system, the failures of the Food and Drug Administration, and enormous profits made by a large pharmaceutical corporation at the potential cost of thousands of lives.

In 1960, the FDA approved the contraceptive commonly known as “the pill.” Advocates, developers, and manufacturers believed that the convenient new drug would put an end to unwanted pregnancy, ensure happy marriages, and even eradicate poverty. But as renowned historian Elaine Tyler May reveals inAmerica and the Pill, it was women who embraced it and created change. They used the pill to challenge the authority of doctors, pharmaceutical companies, and lawmakers. They demonstrated that the pill was about much more than family planning—it offered women control over their bodies and their lives. From little-known accounts of the early years to personal testimonies from young women today, May illuminates what the pill did and didnotachieve during its half century on the market.

Mangano discusses a unique, all-natural system for lowering blood pressure that is not based on a single approach such as stress reduction, herbs or special foods, or exercise. It's based on a combination of methods that have been scientifically proven to work.

A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.

Peter Walker—reporter at the Guardian and curator of its popular bike blog—shows how the future of humanity depends on the bicycle. Car culture has ensnared much of the world—and it's no wonder. Convenience and comfort (as well as some clever lobbying) have made the car the transportation method of choice for generations. But as the world evolves, the high cost of the automobile is made clearer—with its dramatic effects on pollution, the way it cuts people off from their communities, and the alarming rate at which people are injured and killed in crashes. Walker argues that the simplest way to tackle many of these problems at once is with one of humankind's most perfect inventions—the bicycle. In How Cycling Can Save the World, Walker takes readers on a tour of cities like Copenhagen and Utrecht, where everyday cycling has taken root, demonstrating cycling’s proven effect on reducing smog and obesity, and improving quality of life and mental health. Interviews with public figures—such as Janette Sadik-Khan, who led the charge to create more pedestrian- and cyclist- friendly infrastructure in New York City—provide case studies on how it can be done, and prove that you can make a big change with just a few cycling lanes and a paradigm shift. Meticulously researched and incredibly inspiring, How Cycling Can Save the World delivers on its lofty promise and leads readers to the realization that cycling could not only save the world, but have a lasting and positive impact on their own lives.