Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

Ptolemy's Almagest is one of the most influential scientific works in history. A masterpiece of technical exposition, it was the basic textbook of astronomy for more than a thousand years, and still is the main source for our knowledge of ancient astronomy. This translation, based on the standard Greek text of Heiberg, makes the work accessible to English readers in an intelligible and reliable form. It contains numerous corrections derived from medieval Arabic translations and extensive footnotes that take account of the great progress in understanding the work made in this century, due to the discovery of Babylonian records and other researches. It is designed to stand by itself as an interpretation of the original, but it will also be useful as an aid to reading the Greek text.

Writing at the time of political and social crisis in Athens, Aristophanes was an eloquent yet bawdy challenger to the demagogue and the sophist. The Achanians is a plea for peace set against the background of the long war with Sparta.