The term arthrogryposis describes a range of congenital contractures that lead to childhood deformities. It encompasses a number of syndromes and sporadic deformities that are rare individually but collectively are not uncommon. Yet, the existing medical literature on arthrogryposis is sparse and often confusing. The aim of this book is to provide individuals affected with arthrogryposis, their families, and health care professionals with a helpful guide to better understand the condition and its therapy. With this goal in mind, the editors have taken great care to ensure that the presentation of complex clinical information is at once scientifically accurate, patient oriented, and accessible to readers without a medical background. The book is authored primarily by members of the medical staff of the Arthrogryposis Clinic at Children's Hospital and Medical Center in Seattle, Washington, one of the leading teams in the management of the condition, and will be an invaluable resource for both health care professionals and families of affected individuals.

Gregory Bateson was a philosopher, anthropologist, photographer, naturalist, and poet, as well as the husband and collaborator of Margaret Mead. This classic anthology of his major work includes a new Foreword by his daughter, Mary Katherine Bateson. 5 line drawings.

Paperback version of the 2002 paper published in the journal Progress in Information, Complexity, and Design (PCID). ABSTRACT Inasmuch as science is observational or perceptual in nature, the goal of providing a scientific model and mechanism for the evolution of complex systems ultimately requires a supporting theory of reality of which perception itself is the model (or theory-to-universe mapping). Where information is the abstract currency of perception, such a theory must incorporate the theory of information while extending the information concept to incorporate reflexive self-processing in order to achieve an intrinsic (self-contained) description of reality. This extension is associated with a limiting formulation of model theory identifying mental and physical reality, resulting in a reflexively self-generating, self-modeling theory of reality identical to its universe on the syntactic level. By the nature of its derivation, this theory, the Cognitive Theoretic Model of the Universe or CTMU, can be regarded as a supertautological reality-theoretic extension of logic. Uniting the theory of reality with an advanced form of computational language theory, the CTMU describes reality as a Self Configuring Self-Processing Language or SCSPL, a reflexive intrinsic language characterized not only by self-reference and recursive self-definition, but full self-configuration and self-execution (reflexive read-write functionality). SCSPL reality embodies a dual-aspect monism consisting of infocognition, self-transducing information residing in self-recognizing SCSPL elements called syntactic operators. The CTMU identifies itself with the structure of these operators and thus with the distributive syntax of its self-modeling SCSPL universe, including the reflexive grammar by which the universe refines itself from unbound telesis or UBT, a primordial realm of infocognitive potential free of informational constraint. Under the guidance of a limiting (intrinsic) form of anthropic principle called the Telic Principle, SCSPL evolves by telic recursion, jointly configuring syntax and state while maximizing a generalized self-selection parameter and adjusting on the fly to freely-changing internal conditions. SCSPL relates space, time and object by means of conspansive duality and conspansion, an SCSPL-grammatical process featuring an alternation between dual phases of existence associated with design and actualization and related to the familiar wave-particle duality of quantum mechanics. By distributing the design phase of reality over the actualization phase, conspansive spacetime also provides a distributed mechanism for Intelligent Design, adjoining to the restrictive principle of natural selection a basic means of generating information and complexity. Addressing physical evolution on not only the biological but cosmic level, the CTMU addresses the most evident deficiencies and paradoxes associated with conventional discrete and continuum models of reality, including temporal directionality and accelerating cosmic expansion, while preserving virtually all of the major benefits of current scientific and mathematical paradigms.

This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.

This paper provides guidelines for new high-throughput screening methods – both phenotypic and genotypic – to enable the detection of rare mutant traits, and reviews techniques for increasing the efficiency of crop mutation breeding.

Biological evolution is a fact—but the many conflicting theories of evolution remain controversial even today. When Adaptation and Natural Selection was first published in 1966, it struck a powerful blow against those who argued for the concept of group selection—the idea that evolution acts to select entire species rather than individuals. Williams’s famous work in favor of simple Darwinism over group selection has become a classic of science literature, valued for its thorough and convincing argument and its relevance to many fields outside of biology. Now with a new foreword by Richard Dawkins, Adaptation and Natural Selection is an essential text for understanding the nature of scientific debate.

Developmental biology is at the core of all biology. This text emphasizes the principles and key developments in order to provide an approach and style that will appeal to students at all levels.

Elegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things. Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine. Lewis Thomas writes, "Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us."

The second edition of this quick reference handbook for obstetricians and gynecologists and primary care physicians is designed to complement the parent textbook Clinical Obstetrics: The Fetus & Mother The third edition of Clinical Obstetrics: The Fetus & Mother is unique in that it gives in-depth attention to the two patients – fetus and mother, with special coverage of each patient. Clinical Obstetrics thoroughly reviews the biology, pathology, and clinical management of disorders affecting both the fetus and the mother. Clinical Obstetrics: The Fetus & Mother - Handbook provides the practising physician with succinct, clinically focused information in an easily retrievable format that facilitates diagnosis, evaluation, and treatment. When you need fast answers to specific questions, you can turn with confidence to this streamlined, updated reference.