Coping with modern technology in the life sciences (biology and medicine) became a major issue for people living in the Twentieth Century, and continues to be so in the present century. Biotechnology creates new opportunities and possibilities, but also new dangers, risks, and ethical concerns. In this volume, ethical dilemmas in the context of a specific biomedical technology are discussed. Experts in ethics, philosophy, psychoanalysis, and medicine jointly investigated a field of prenatal and genetic research that seems particularly challenging: prenatal diagnostics. In many European countries amniocentesis, for example, is a routine diagnostic tool for women becoming pregnant after the age of thirty-five. In recent decades, enormous progress has been made in diagnosing genetically-based diseases and other serious prenatal abnormalities. Today, we know that a positive prenatal genetic diagnostic creates distress for all women and their partners, and necessitates making the difficult decision as to whether or not to allow the pregnancy to continue. As is demonstrated in this volume through the summaries of interviews with couples, the reactions of women and their partners who are facing this situation can be very different. The new and innovative interdisciplinary dialogue on this topic that is presented in this volume offers a deeper understanding of the ethical dilemmas raised by prenatal and genetic diagnostics, and explores ways to support couples in this extremely difficult situation.

For Jones the establishment of a definitive relationship between individual and society is central to the development of both engaged Buddhism and sociology. Here he tells readers how to bridge their spiritual practice to social action.

Together with Consulting Editor Dr. William Rayburn, Drs. D. Michael Nelson and Leslie Myatt have put together a unique issue that discusses The Human Placenta in Health and Disease. Expert authors have contributed clinical review articles on the following topics: Why obstetricians know the future health of the babies they deliver; How obstetricians can predict the future health of mothers after a complicated pregnancy; What obstetricians need to know about placental pathology; Immunology of the placenta; Diabetes mellitus, obesity, and the placenta; Intrauterine growth restriction and placental dysfunction; The placenta as the root cause for preeclampsia; Placental anatomy and function in twin gestations; Placental implantation disorders: accreta, previa, and abruptio placentae; Key infections in the placenta; Chorioamnion function in normal and abnormal pregnancy; The future for imaging modalities of the human placenta; Artificial reproductive technologies and the decidual and placental development interface; and When the fetus goes still and the birth is tragic: The role of the placenta in stillbirths. Readers will come away with the clinical information they need to improve outcomes in the women, mothers, and infants.

Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way. - Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseases - Summarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was established - Provides stimulating discussions on developing new medical therapiesHighlights the importance of studying humans to understand mechanisms of disease that affect humans

The Handbook of Chronic Kidney Disease Management focuses on practical aspects of managing patients with mild to moderate Chronic Kidney Disease (CKD), incorporating the expertise of cardiologists, endocrinologists, general internists, and nephrologists. Chapters include case vignettes and management algorithms, and treatment recommendations reconcile recently published clinical guidelines from NKF, AHA, NCEP, and ADA. In addition, treatment recommendations in this handbook take into account the realities of reimbursements in the U.S.

Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. - Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles - Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology - Delves into unanswered questions and future directions of this important blood-clotting complex

With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease. This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology, immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk–benefit ratios when managing patients with rheumatic irAE. Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.

In this issue of Clinics in Chest Medicine, guest editors Drs. Erick Forno and Gregory Sawicki bring their considerable expertise to the topic of Pediatric Respiratory Disease. Top experts discuss COVID-19 in pediatric populations; environmental exposures and pediatric respiratory disease; genetics and genomics in childhood respiratory diseases; microbiome and metabolome: their role in pediatric respiratory disease; and more. - Contains 21 relevant, practice-oriented topics including sickle cell disease and the lung; pediatric lung transplantation; health equity and advocacy in pediatric pulmonology; pediatric pulmonology in low-middle income countries; childhood interstitial lung diseases; primary cilliary dyskinesia; and more. - Provides in-depth clinical reviews on pediatric respiratory disease, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Published in association with the Society for Vascular Surgery, Rutherford’s Vascular Surgery presents state-of-the-art updates on all aspects of vascular health care. Extensively revised by many new authors to meet the needs of surgeons, interventionalists, and vascular medicine specialists, this medical reference book incorporates medical, endovascular and surgical treatment, as well as diagnostic techniques, decision making and fundamental vascular biology. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a full-color layout and images. Get answers you can depend on. Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, is written by international experts, and includes up-to-date bibliographies and annotated recommended references. Discover emerging techniques in rapidly advancing topics, with special emphasis on endovascular coverage, vascular imaging, angiography, CT and MRI. Explore brand new chapters on dialysis catheters, renovascular disease, and management of branches during endovascular aneurysm. Stay up-to-date with the latest coverage of endovascular procedures that reflects the changing practices and techniques in vascular surgery. Access videos at Expert Consult.