Exposure to toxic chemicals or environmental pollutants may harm the health of the nation¿s 74 million children and contribute to increases in asthma and developmental impairments. In 1997, Executive Order 13045 mandated that agencies place a high priority on children¿s risks and required that policies, programs, activities, and standards address those risks. In response, the EPA created the Office of Children¿s Health Protection and convened the Children¿s Health Protection Advisory Comm. This report assesses the extent to which EPA has institutionalized consideration of children¿s health through: (1) strategies and priorities; (2) key offices and other child-focused resources; and (3) participation in interagency efforts. Charts and tables.

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives w

Human and Ecological Risk Assessment: Theory and Practice assembles the expertise of more than fifty authorities from fifteen different fields, forming a comprehensive reference and textbook on risk assessment. Containing two dozen case studies of environmental or human health risk assessments, the text not only presents the theoretical underpinnings of the discipline, but also serves as a complete handbook and "how-to" guide for individuals conducting or interpreting risk assessments. In addition, more than 4,000 published papers and books in the field are cited. Editor Dennis Paustenbach has assembled chapters that present the most current methods for conducting hazard identification, dose-response and exposure assessment, and risk characterization components for risk assessments of any chemical hazard to humans or wildlife (fish, birds, and terrestrials). Topics addressed include hazards posed by: Air emissions Radiological hazards Contaminated soil and foods Agricultural hazards Occupational hazards Consumer products and water Hazardous waste sites Contaminated air and water The bringing together of so many of the world's authorities on these topics, plus the comprehensive nature of the text, promises to make Human and Ecological Risk Assessment the text against which others will be measured in the coming years.

This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European EMEA legislation, and how to develop appropriate information for submission to both agencies. It also provides practical study designs and approaches that can be used to meet international requirements. Covering the full scope of non-clinical testing, regulations, models, practice, and relation to clinical trials, this text offers a comprehensive and up-to-date resource.

"Children are exposed to a series of environmental threats to their health, physical and mental development--even their survival. Preliminary estimates suggest that up to one-third of the global burden of disease can be attributed to negative environmental indicators, such as polluted water and air. The good news is that morbidity and mortality due to unhealth environmental conditions are largely preventable by taking decisive action and finding innovative, healthy, cost-effective and sustainable ways to develop and improve our livelihoods. As this books outlines, prevention is the only sustainable solution: a healthy future for our children will be ensured only through safeguarding the environment. By illustrating the link between the environment and the well-being of our children, Children in the new millennium intends to raise awareness and deepen our understanding of environmental health issues. Providing an informed basis for action and practical recommendations at different levels, the three United Nations agencies involved with the production of Children in the new millennium hope to inspire everyone who cares about children to take decisive action that will improve both their helath and that of the environment.