In the literary pantheon, Charles Bukowski remains a counterculture luminary. A hard-drinking wild man of literature and a stubborn outsider to the poetry world, he has struck a chord with generations of readers, writing raw, tough poetry about booze, work, and women in an authentic voice that is, like the work of the Beats, iconoclastic and even dangerous. Edited by his longtime publisher, John Martin, of Black Sparrow Press, and now in paperback, The Continual Condition includes more of this legend’s never-before-collected poems.

In the literary pantheon, Charles Bukowski remains a counterculture luminary. A hard-drinking wild man of literature and a stubborn outsider to the poetry world, he has struck a chord with generations of readers, writing raw, tough poetry about booze, work, and women in an authentic voice that is, like the work of the Beats, iconoclastic and even dangerous. Edited by his longtime publisher, John Martin, of Black Sparrow Press, and now in paperback, The Continual Condition includes more of this legend’s never-before-collected poems.

From Jan Karon, the #1 New York Times bestselling author of the Mitford series comes a collection of Father Tim's favorite words of wisdom and spiritual inspiration... For years, Mitford’s Father Tim Kavanagh has transcribed into his dog-eared journals words of wisdom, faith, and encouragement. Written in his own hand or typed on his idiosyncratic Royal typewriter, A Continual Feast contains the lively ideas, common sense, profound wisdom, and plain good humor he has gleaned from the likes of C. S. Lewis, Emily Dickinson, William Blake, Helen Keller, G. K. Chesterton, and Will Rogers, to name just a few. Together with its successful companion volume, Patches of Godlight, Father Tim’s latest quote journal is sure proof of the truth of an entry from Lord Byron: "A small drop of ink produces that which makes thousands think." This entertaining and useful handbook is for all those who relish a good “Aha!,” including authors, clergy, speechmakers, dog lovers, and anyone who enjoys provocative insight into everything from the righteous to the ridiculous.

Not all scientific discoveries are genius. Continual Raving tells the combined stories of how scientists across the 19th and 20th centuries defeated meningitis -- not through flawless scientific research, but often through a series of serendipitous events, misplaced assumptions, and flawed conclusions. The result is a story of not just a vanquished disease, but how scientific accomplishment sometimes occurs where it's least expected. Although symptoms of meningitis were recorded as early as Hippocrates and the ancient Greeks, our understanding of the disease's origins and mechanisms remained obscure for most of human history. That changed in 1892, when German physician Richard Pfeiffer observed and isolated bacteria ultimately shown to cause meningitis in children -- and concluded that those bacteria cause influenza. Haemophilus influenzae, as thee meningitis-causing bacteria have been erroneously named ever since, continued their strange journey to discovery in the decades that followed. Continual Raving traces the disease's strange encounters with science, including: - Heinrich Quincke, the German internist who first used a needle to draw spinal fluid from between a patient's back bones - Simon Flexner's management of American meningitis epidemics using immune serum from a horse - American bacteriologist Margaret Pittman's discovery (during the Great Depression, no less) of a sugar overcoat that protects the bacteria from white blood cells - Pediatrician Ashley Weech, who gave the first antibiotic used in America (based on instructions written in German) to a young patient sick with meningitis - Microbiologist Hattie Alexander, who learned why these antibiotics sometimes fail in such patients - Four scientists, in two teams, as they vied to be the first to create the right vaccine to prevent meningitis in infants In each of these deeply human stories, variables of chance, circumstance, and incorrect assumptions intervene to shape not just the arc of the scientists' lives, but the trajectory of how humans have come to understand one of our most pernicious diseases. Continual Raving is a mosaic tale of how science conquered meningitis -- and a larger story of the sometimes winding road to discovery.

A collection of daily devotionals of substance. This lovely gift edition includes a meditation and poem for each day of the year, plus a yearly Scripture-reading plan.

South of No North is a collection of short stories written by Charles Bukowski that explore loneliness and struggles on the fringes of society.

This publication focuses on continual service improvement (CSI) from both an IT service and IT service management perspective. It introduces the concept of CSI at a high level and defines its value before describing common methods and techniques. The guidance is written for managers and practitioners at all levels.

A decade after the sudden and tragic loss of his father, we witness the unfolding of grief. “In the night I brush / my teeth with a razor,” he tells us, in one of the collection’s piercing two-line poems. Capturing the strange silence of bereavement (“Not the storm / but the calm / that slays me”), Kevin Young acknowledges, even celebrates, life’s passages, his loss transformed and tempered in a sequence about the birth of his son: in “Crowning,” he delivers what is surely one of the most powerful birth poems written by a man, describing “her face / full of fire, then groaning your face / out like a flower, blood-bloom,/ crocused into air.” Ending this book of both birth and grief, the gorgeous title sequence brings acceptance, asking “What good/are wishes if they aren’t / used up?” while understanding “How to listen / to what’s gone.” Young’s frank music speaks directly to the reader in these elemental poems, reminding us that the right words can both comfort us and enlarge our understanding of life’s mysteries.

As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, Dose Finding by the Continual Reassessment Method features: Real clinical trial examples that illustrate the methods and techniques throughout the book Detailed calibration techniques that enable biostatisticians to design a CRM in timely manner Limitations of the CRM are outlined to aid in correct use of method This book supplies practical, efficient dose-finding methods based on cutting edge statistical research. More than just a cookbook, it provides full, unified coverage of the CRM in addition to step-by-step guidelines to automation and parameterization of the methods used on a regular basis. A detailed exposition of the calibration of the CRM for applied statisticians working with dose-finding in phase I trials, the book focuses on the R package ‘dfcrm’ for the CRM and its major variants. The author recognizes clinicians’ skepticism of model-based designs, and addresses their concerns that the time, professional, and computational resources necessary for accurate model-based designs can be major bottlenecks to the widespread use of appropriate dose-finding methods in phase I practice. The theoretically- and empirically-based methods in Dose Finding by the Continual Reassessment Method will lessen the statistician’s burden and encourage the continuing development and implementation of model-based dose-finding methods.

One of the most gifted poets of our time, Adam Zagajewski is a contemporary classic. Few writers in poetry or prose have attained the lucid intelligence and limpid economy of style that are the trademarks of his work. His wry humor, gentle skepticism, and perpetual sense of history's dark possibilities have earned him a devoted international following. This collection, gracefully translated by Clare Cavanagh, finds the poet returning to the themes that have defined his career—moving meditations on place, language, and history. Unseen Hand is a luminous meeting of art and everyday life.