"Everyone dies, and so, we naturally associate death with the end of an individual life. However, life is much more complicated, and death is actually interwoven into biology at many levels. Normal development and life could not exist without carefully regulated death of certain cells and as one defense against disease. Other cells wear out and die and must be replaced regularly. On a larger scale, death has influenced the direction of entire species. In fact, death has shaped all life through the cycle of life and death, throughout time, and in normal development. It affects our cells, our development, and our life"--

Why do we die? Do all living creatures share this fate? Is the body's slow degradation with the passage of time unavoidable, or can the secrets of longevity be unlocked? Over the past two decades, scientists studying the workings of genes and cells have uncovered some of the clues necessary to solve these mysteries. In this fascinating and accessible book, two neurobiologists share the often-surprising findings from that research, including the possibility that aging and natural death may not be forever a certainty for most living beings. André Klarsfeld and Frédéric Revah discuss in detail the latest scientific findings and views on death and longevity. They challenge many popular assumptions, such as the idea that the death of individual organisms serves to rejuvenate species or that death and sexual reproduction are necessarily linked. Finally, they describe current experimental approaches to postpone natural death in lower organisms as well as in mammals. Are all organisms that survive until late in life condemned to a "natural" death, as a consequence of aging, even if they live in a well-protected, supportive environment? The variability of the adult life span--from a few hours for some insects to more than a millennium for the sequoia and thirteen times that for certain wild berry bushes--challenges the notion that death is unavoidable. Evolutionary theory helps explain why and how some species have achieved biological mechanisms that seemingly allow them to resist time. Death cannot be understood without looking into cells--the essential building blocks of life. Intriguingly, at the level of cells, death is not always an accident; it is often programmed as an indispensable aspect of life, which benefits the organism as a whole.

In this introduction to philosophy of biology, Kim Sterelny and Paul E. Griffiths present both the science and the philosophical context necessary for a critical understanding of the debates shaping biology at the end of the 20th century.

The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.

This book is open access under a CC BY 4.0 licence. This book is a multidisciplinary work that investigates the notion of posthumous harm over time. The question what is and when is death, affects how we understand the possibility of posthumous harm and redemption. Whilst it is impossible to hurt the dead, it is possible to harm the wishes, beliefs and memories of persons that once lived. In this way, this book highlights the vulnerability of the dead, and makes connections to a historical oeuvre, to add critical value to similar concepts in history that are overlooked by most philosophers. There is a long historical view of case studies that illustrate the conceptual character of posthumous punishment; that is, dissection and gibbetting of the criminal corpse after the Murder Act (1752), and those shot at dawn during the First World War. A long historical view is also taken of posthumous harm; that is, body-snatching in the late Georgian period, and organ-snatching at Alder Hey in the 1990s.

With its easy-to-read and personal style, this book provides some intriguing new explanations of the physiology of death and the dying experience.--Susan Blackmore, PhD, Author of Dying to LiveDying is the last conscious experience undergone by each person. But what do the dying experience? In the last few decades a good deal of publicity has surrounded people who have been close to death and then reported intense experiences that seem to suggest a supernatural existence beyond death. Does the conscious mind somehow continue to exist after the body has passed away? Mortal Minds answers these questions.Dr. G. M. Woerlee explains how the normal functioning of the human body near death can generate beliefs in the reality of the supernatural and life after death. An anesthesiologist with more than twenty years of hospital experience, Dr. Woerlee has been struck over the years by the similarities between the body's symptoms under anesthesia and its reactions near death. Among the issues he addresses are the sensations of being disembodied that those near death often describe, the perception that mind and body are separate components of existence, whether there is such a thing as a soul, the physical effects of decreased oxygen to the brain, and the visions that the dying sometimes report, from rapturous experiences of eternal peace to diabolical dreams.While not dismissing near death experiences as mere hallucinations, Dr. Woerlee is also careful to point out that even powerful psychological impressions by themselves do not constitute scientific proof of life after death. Taking this balanced, objective stance, he succeeds in conveying a better understanding of the dying process and helping us all to realize the nature of these final experiences.G. M. Woerlee (Leiden, The Netherlands) is an anesthesiologist affiliated with the Rijnland Hospital in Leiderdorp, The Netherlands, and the author of two books on anesthesiology.

The question of why an individual would actively kill itself has long been an evolutionary mystery. Pierre M. Durand’s ambitious book answers this question through close inspection of life and death in the earliest cellular life. As Durand shows us, cell death is a fascinating lens through which to examine the interconnectedness, in evolutionary terms, of life and death. It is a truism to note that one does not exist without the other, but just how does this play out in evolutionary history? These two processes have been studied from philosophical, theoretical, experimental, and genomic angles, but no one has yet integrated the information from these various disciplines. In this work, Durand synthesizes cellular studies of life and death looking at the origin of life and the evolutionary significance of programmed cellular death. The exciting and unexpected outcome of Durand’s analysis is the realization that life and death exhibit features of coevolution. The evolution of more complex cellular life depended on the coadaptation between traits that promote life and those that promote death. In an ironic twist, it becomes clear that, in many circumstances, programmed cell death is essential for sustaining life.

In The Evolution of Death, the follow-up to Becoming Immortal: Combining Cloning and Stem-Cell Therapy, also published by SUNY Press, Stanley Shostak argues that death, like life, can evolve. Observing that literature, philosophy, religion, genetics, physics, and gerontology still struggle to explain why we die, Shostak explores the mystery of death from a biological perspective. Death, Shostak claims, is not the end of a linear journey, static and indifferent to change. Instead, he suggests, the current efforts to live longer have profoundly affected our ecological niche, and we are evolving into a long-lived species. Pointing to the artificial means currently used to prolong life, he argues that as we become increasingly juvenilized in our adult life, death will become significantly and evolutionarily delayed. As bodies evolve, the embryos of succeeding generations may be accumulating the stem cells that preserve and restore, providing the resources necessary to live longer and longer. If trends like this continue, Shostak contends, future human beings may join the ranks of other animals with indefinite life spans.

A million cells in our bodies die every second--they commit suicide by activating a process called apoptosis or other forms of programmed cell death. These mechanisms are essential for survival of the body as a whole and play critical roles in various developmental processes, the immune system, and cancer. In this second edition of Douglas Green's essential book on cell death, Green retains the bottom-up approach of the first edition, starting with the enzymes that carry out the execution (caspases) and their cellular targets before examining the machinery that connects them to signals that cause cell death. He also describes the roles of cell death in development, neuronal selection, and the development of self-tolerance in the immune system, as well as how the body uses cell death to defend against cancer. The new edition is fully updated to cover the many recent advances in our understanding of the death machinery and signals that control cell death. These include the mechanisms regulating necroptosis, mitophagy, and newly identified processes, such as ferroptosis. The book will thus be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time.