This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a "fully" sequenced genome, ii) rapid (~3 month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics to assess gene function. Gene knockdown in embryos and the production of transgenic strains are now standard techniques being used to assess physiology. This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists and developmental biologists. - Integrates and synthesizes the biology of the zebrafish under one cover - Features contributions from the leading researchers in their fields - Reaches a wider audience of researchers and biologists with its broad inclusion of subjects relating to zebrafish physiology

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

August Krogh, the son of a brewer, studied zoology in Copenhagen and earned his doctoral degree under the physiologist Christian Bohr, the father of the world-renowned nuclear physicist Niels Bohr. Krogh's unusual ability to construct instruments and complex apparatuses and his intuitive understanding of physical principles made it possible for him to improve on Bohr's methods. His findings led him to challenge Christian Bohr's ideas about oxygen secretion, and when Bohr refused to accept his findings, Krogh unwillingly came into a painful conflict with his own mentor. Krogh's continued studies of how oxygen is supplied to the tissues led to his realization that the blood flow in the finest blood vessels, the capillaries, has to be regulated through a mechanism that opens and closes the capillaries according to the tissue's need for oxygen. This idea and his scientific proof were at the time so new and revolutionary that he was promptly (in 1920) awarded the Nobel Prize. His fame in Denmark and all over the world continued to grow until his death in 1949. His scientific discoveries extended from respiration, exercise physiology and capillary physiology into comparative osmoregulation, isotope studies, active transport of ions in plants and animals, and finally insect flight. Another dramatic story of Krogh's life began when he introduced insulin production in Denmark in 1922. This move saved his own wife's life as well as numerous other lives and helped make Denmark's Novo-Nordisk the largest producer of insulin in the world today. Krogh's wife, Marie, became a physician and a renowned scientist in her own right. Throughout their harmonious marriage and partnership, Marie played an important role in her husband's life both scientifically and personally. Written by the proud daughter of August and Marie Krogh, this biography is based on numerous letters, scientific papers, interviews, symposia, and other sources as well as the author's own knowledge of her parents. The intertwining of the scientific work and personal lives of these two remarkable people is beautifully illustrated in a well-rounded picture of their struggles and triumphs. It is a unique book, full of human warmth and scientific understanding.

Hematology encompasses the physiology and pathology of blood and of the blood-forming organs. In common with other areas of medicine, the pace of change in hematology has been breathtaking over recent years. There are now many treatment options available to the modern hematologist and, happily, a greatly improved outlook for the vast majority of patients with blood disorders and malignancies. Improvements in the clinic reflect, and in many respects are driven by, advances in our scientific understanding of hematological processes under both normal and disease conditions. Hematology - Science and Practice consists of a selection of essays which aim to inform both specialist and non-specialist readers about some of the latest advances in hematology, in both laboratory and clinic.