The Alzheimer Conundrum

The Alzheimer Conundrum
Author :
Publisher : Princeton University Press
Total Pages : 328
Release :
ISBN-10 : 9780691168470
ISBN-13 : 0691168474
Rating : 4/5 (70 Downloads)

Synopsis The Alzheimer Conundrum by : Margaret Lock

Why our approaches to Alzheimer's and dementia are problematic and contradictory Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.

The Alzheimer Conundrum

The Alzheimer Conundrum
Author :
Publisher :
Total Pages : 328
Release :
ISBN-10 : OCLC:1105801082
ISBN-13 :
Rating : 4/5 (82 Downloads)

Synopsis The Alzheimer Conundrum by : Margaret Lock

Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.

Alzheimer's Disease Memoirs

Alzheimer's Disease Memoirs
Author :
Publisher : Springer Nature
Total Pages : 160
Release :
ISBN-10 : 9789811661129
ISBN-13 : 981166112X
Rating : 4/5 (29 Downloads)

Synopsis Alzheimer's Disease Memoirs by : Pramod K Nayar

This book examines writings by people living with Alzheimer's Disease and their caregivers. Its focus areas include the construction of the self in the face of diminishing linguistic and cognitive abilities, the stigmatization of ageing, the various narrative strategies that these texts (often collaborative) employ, the health activism and advocacy generated via a 'biosociality,' and the ethics of care. It examines the 'disease writing' genre about a condition that ravages the ability to use language. It serves as a "literary" examination of the work done in this area through a critical reading of the memoirs of those with AD and caregivers and a healthy dose of literary theory. The book is a valuable resource for those interested in literary and critical theory and researchers in the field of ageing/dementia studies.

The End of Alzheimer's

The End of Alzheimer's
Author :
Publisher : Academic Press
Total Pages : 484
Release :
ISBN-10 : 9780128121139
ISBN-13 : 0128121130
Rating : 4/5 (39 Downloads)

Synopsis The End of Alzheimer's by : Thomas J. Lewis

The End of Alzheimer's: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer's outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer's disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer's outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer's, and will hopefully redirect many into new avenues of cellular research and discovery. - Comprehensive literature-based summary of the current state of molecular Alzheimer's disease research - Details the shortcomings of the prevailing model and therapeutics in development - Reviews blood-based biomarkers for Alzheimer's and their link to amyloid- and Tau-independent causes outside the brain - Describes the tissues outside the brain impacted by Alzheimer's and the underlying molecular causes - Explains the whole-body risks associated with Alzheimer's, along with concomitant measures to slow or prevent the disease - Provides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer's patients

Emerging Technologies for Diagnosing Alzheimer's Disease

Emerging Technologies for Diagnosing Alzheimer's Disease
Author :
Publisher : Springer
Total Pages : 300
Release :
ISBN-10 : 9781137540973
ISBN-13 : 1137540974
Rating : 4/5 (73 Downloads)

Synopsis Emerging Technologies for Diagnosing Alzheimer's Disease by : Marianne Boenink

This book explores international biomedical research and development on the early diagnosis of Alzheimer's disease. It offers timely, multidisciplinary reflections on the social and ethical issues raised by promises of early diagnostics and asks under which conditions emerging diagnostic technologies can be considered a responsible innovation. The initial chapters in this edited volume provide an overview and a critical discussion of recent developments in biomedical research on Alzheimer's disease. Subsequent contributions explore the values at stake in current practices of dealing with Alzheimer's disease and dementia, both within and outside the biomedical domain. Novel diagnostic technologies for Alzheimer's disease emerge in a complex and shifting field, full of controversies. Innovating with care requires a precise mapping of how concepts, values and responsibilities are filled in through the confrontation of practices. In doing so, the volume offers a practice-based approach of responsible innovation that is also applicable to other fields of innovation.

The Neuropathology of Dementia

The Neuropathology of Dementia
Author :
Publisher : Cambridge University Press
Total Pages : 600
Release :
ISBN-10 : 0521819156
ISBN-13 : 9780521819152
Rating : 4/5 (56 Downloads)

Synopsis The Neuropathology of Dementia by : Margaret M. Esiri

Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta
Author :
Publisher : Springer Science & Business Media
Total Pages : 442
Release :
ISBN-10 : 0387232257
ISBN-13 : 9780387232256
Rating : 4/5 (57 Downloads)

Synopsis Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta by : J. Robin Harris

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

The Problem of Alzheimer's

The Problem of Alzheimer's
Author :
Publisher : St. Martin's Press
Total Pages : 269
Release :
ISBN-10 : 9781250218742
ISBN-13 : 1250218748
Rating : 4/5 (42 Downloads)

Synopsis The Problem of Alzheimer's by : Jason Karlawish

A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.

Chronic Inflammation

Chronic Inflammation
Author :
Publisher : Springer
Total Pages : 679
Release :
ISBN-10 : 9784431560685
ISBN-13 : 4431560688
Rating : 4/5 (85 Downloads)

Synopsis Chronic Inflammation by : Masayuki Miyasaka

This book provides readers with the most up-to-date information on cutting-edge research concerning chronic inflammation. We now know that when inflammation becomes chronic, it acts as a strong disease-promoting factor in a variety of disorders including arteriosclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation is hence called as the “silent killer”; it upsets the body’s homeostatic mechanism insidiously. In spite of these developments, we know very little about the mechanism underlying chronic inflammation. Particularly, we do not know precisely what induces chronic inflammation or what promotes its prolongation in a spatiotemporal framework. Neither do we have clear knowledge about how chronic inflammation destroys various tissues or how it predisposes individuals to many different diseases. To make the situation worse, we have no effective treatment against chronic inflammation. Since 2010, two major research programs (CREST and PRESTO) aimed at clarifying the mechanisms underlying chronic inflammation were launched in Japan, and investigators of different research areas with a brilliant track record were selected by their research proposals. Subsequently they have made their best efforts to answer the conundrum concerning chronic inflammation. This book is a compendium of such research efforts. In each chapter, the CREST- or PRESTO-funded researchers summarize their original work concerning mechanisms of induction, progression, or resolution underlying chronic inflammation. The most emphasized characteristic is the molecular aspect of chronic inflammation. The book thus presents the most recent progress made in the molecular understanding of chronic inflammation.

The End of Alzheimer's?

The End of Alzheimer's?
Author :
Publisher : Tjlphd, LLC
Total Pages : 480
Release :
ISBN-10 : 0692349855
ISBN-13 : 9780692349854
Rating : 4/5 (55 Downloads)

Synopsis The End of Alzheimer's? by : Thomas J Lewis Ph D

There is hope for sufferers of Alzheimer's disease and for those concerned about their future risk for the disease. The solution lies in the diagnosis, not in the treatments designated for the disease today. Alzheimer's is NOT a disease exclusively of the brain. A thorough broad and deep diagnosis of your entire health will often provide answers about the causes of Alzheimer's. With this knowledge in hand, you and your doctor may take measures to prevent, slow, stop, or reverse Alzheimer's and other forms of dementia. In "The End of Alzheimer's - A Differential Diagnosis Toward a Cure." Drs. Lewis and Trempe explore the disease and a proper diagnosis in detail. They describe the pitfalls and shortcoming of current medical research and clinical medicine. Most importantly they provide a simplified guide through a mountain of emerging science and medical information and explain what to obtain for a proper and comprehensive diagnosis, why there is hope for disease sufferers today, and forecast optimism for effective treatments in the future. They also include a 5-phase program to prevent Alzheimer's, diagnosis the disease in asymptomatic people, find route causes of the disease, and offer disease management and treatment advice. Here is what experts are saying about "The End of Alzheimer's?" Dr. Alzheimer, for whom Alzheimer's disease is named, would be totally perplexed and disheartened at the fact that after a century of research and over 100,000 scientific and medical papers written on the subject, patients presently diagnosed with Alzheimer's disease are no better off now than they were in 1907, when he diagnosed the first Alzheimer's case. This fact alone invites the troubling question, are we on the right track to finding a way to help Alzheimer patients? To search for an answer to this consequential question, one needs to read "The End of Alzheimer's?" by Dr. Thomas Lewis and Dr. Clement Trempe who write about this disquieting problem and possible ways to solve it. Drs. Lewis and Trempe have written a mind-opening, well-informed and intelligent account of the history, present and future interventions, and distillation of keen thinking on the subject of Alzheimer's disease. This book will be the focus of many prospective and pivotal discussions on how medical research will eventually govern this mind-shattering disorder. Jack C. de la Torre, MD, PhD, Professor of Psychology, University of Texas, Austin Austin, Texas 79712, Senior Editor, Journal of Alzheimer's Disease The brilliant strategy by Drs. Lewis and Trempe takes advantage of revolutionary new concepts for guiding enhancement of immune function and treatment of chronic infections in prevention and treatment of Alzheimer's disease. The diagnosis of mild cognitive impairment by psychological testing, combined with assessment of ophthalmological abnormalities and determination of health status through thorough testing of biochemical markers related to infection and inflammation, are necessary for improving the prognosis and reducing the risk of dementia. The implications of this strategy for the individual and for the population are enormous. Control of dementia, atherosclerosis, and degenerative diseases of aging by the insights of Drs. Lewis and Trempe has the potential for revolutionizing management of chronic disease in the general population. Kilmer S. McCully, MD, Chief of Pathology and Laboratory Medicine, United States Department of Veterans Affairs Medical Center, VA Boston Healthcare System, Boston, MA 02132. Pioneer of the Homocysteine Theory.