"A gifted and thoughtful writer, Metzl brings us to the frontiers of biology and technology, and reveals a world full of promise and peril." — Siddhartha Mukherjee MD, New York Times bestselling author of The Emperor of All Maladies and The Gene A groundbreaking exploration of genetic engineering and its impact on the future of our species from leading geopolitical expert and technology futurist, Jamie Metzl. At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race. Enter the laboratories where scientists are turning science fiction into reality. In this captivating and thought-provoking nonfiction science book, Jamie Metzl delves into the ethical, scientific, political, and technological dimensions of genetic engineering, and shares how it will shape the course of human evolution. Cutting-edge insights into the field of genetic engineering and its implications for humanity's future Explores the transformative power of genetic technologies and their potential to reshape human life Examines the ethical considerations surrounding genetic engineering and the choices we face as a species Engaging narrative that delves into the scientific breakthroughs and real-world applications of genetic technologies Provides a balanced perspective on the promises and risks associated with genetic engineering Raises thought-provoking questions about the future of reproduction, human health, and our relationship with nature Drawing on his extensive background in genetics, national security, and foreign policy, Metzl paints a vivid picture of a world where advancements in technology empower us to take control of our own evolution, but also cautions against the pitfalls and ethical dilemmas that could arise if not properly managed. Hacking Darwin is a must-read for anyone interested in the intersection of science, technology, and humanity's future.

As one of the eighteen field-specific reports comprising the comprehensive scope of the strategic general report of the Chinese Academy of Sciences, this sub-report addresses long-range planning for developing science and technology in the field of space science. They each craft a roadmap for their sphere of development to 2050. In their entirety, the general and sub-group reports analyze the evolution and laws governing the development of science and technology, describe the decisive impact of science and technology on the modernization process, predict that the world is on the eve of an impending S&T revolution, and call for China to be fully prepared for this new round of S&T advancement. Based on the detailed study of the demands on S&T innovation in China's modernization, the reports draw a framework for eight basic and strategic systems of socio-economic development with the support of science and technology, work out China's S&T roadmaps for the relevant eight basic and strategic systems in line with China's reality, further detail S&T initiatives of strategic importance to China's modernization, and provide S&T decision-makers with comprehensive consultations for the development of S&T innovation consistent with China's reality. Supported by illustrations and tables of data, the reports provide researchers, government officials and entrepreneurs with guidance concerning research directions, the planning process, and investment. Founded in 1949, the Chinese Academy of Sciences is the nation's highest academic institution in natural sciences. Its major responsibilities are to conduct research in basic and technological sciences, to undertake nationwide integrated surveys on natural resources and ecological environment, to provide the country with scientific data and consultations for government's decision-making, to undertake government-assigned projects with regard to key S&T problems in the process of socio-economic development, to initiate personnel training, and to promote China's high-tech enterprises through its active engagement in these areas.

Blue Magic, the latest designer drug linked to a rash of overdoses, might explain the needle mark on the arm of a young woman found dead in her Kansas City apartment. But when Star reporter Rich Azadian digs deeper, the clues point to a far more explosive story: MaryLee Stock was a special protégée of evangelical megapastor and power broker Cobalt Becker, who is poised to deliver his followers and the presidency to a firebrand right-wing senator in the next election. When Azadian sets out to prove that MaryLee’s death was no accident and she may have been carrying Becker’s genetically enhanced baby, the stakes become life itself. In 2023 America—bankrupt, violently divided by the culture wars, and beholden to archrival China—the rules of the game are complicated. With the danger mounting, the dead bodies of young women piling up, Chinese agents circling, and the US Department of National Competitiveness moving in to quash his investigation, Azadian’s only option is to go rogue, assemble a team of brilliant misfits like himself, and begin the fight of his life to find out who is killing these women and why, and if any others like them may still be alive. Skyhorse Publishing, as well as our Arcade, Yucca, and Good Books imprints, are proud to publish a broad range of books for readers interested in fiction—novels, novellas, political and medical thrillers, comedy, satire, historical fiction, romance, erotic and love stories, mystery, classic literature, folklore and mythology, literary classics including Shakespeare, Dumas, Wilde, Cather, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.

A Guardian Book of the Week Longlisted for the PEN / E. O. Wilson Literary Science Writing Award An award-winning physician and scientist makes the game-changing case that genetic females are stronger than males at every stage of life Here are some facts: Women live longer than men. They have stronger immune systems. They're better at fighting cancer and surviving famine, and even see the world in a wider variety of colors. They are simply stronger than men at every stage of life. Why is this? And why are we taught the opposite? To find out, Dr. Sharon Moalem drew on his own medical experiences - treating premature babies in the neonatal intensive care unit; recruiting the elderly for neurogenetic studies; tending to HIV-positive orphans in Thailand - and tried to understand why in every instance men were consistently less likely to thrive. The answer, he discovered, lies in our genetics: two X chromosomes offer a powerful survival advantage. With clear, captivating prose that weaves together eye-opening research, case studies, diverse examples ranging from the behavior of honeybees to American pioneers, as well as experiences from his personal life and his own patients, Moalem explains why genetic females triumph over males when it comes to resiliency, intellect, stamina, immunity and much more. He also calls for a reconsideration of our male-centric, one-size-fits-all view of medical studies and even how we prescribe medications - a view that still sees women through the lens of men. Revolutionary and yet utterly convincing, The Better Half will make you see humanity and the survival of our species anew.

One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. IIf our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington’s disease. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

In the "black box function optimization" problem, a search strategy is required to find an extremal point of a function without knowing the structure of the function or the range of possible function values. Solving such problems efficiently requires two abilities. On the one hand, a strategy must be capable of learning while searching: It must gather global information about the space and concentrate the search in the most promising regions. On the other hand, a strategy must be capable of sustained exploration: If a search of the most promising region does not uncover a satisfactory point, the strategy must redirect its efforts into other regions of the space. This dissertation describes a connectionist learning machine that produces a search strategy called stochastic iterated genetic hillclimb ing (SIGH). Viewed over a short period of time, SIGH displays a coarse-to-fine searching strategy, like simulated annealing and genetic algorithms. However, in SIGH the convergence process is reversible. The connectionist implementation makes it possible to diverge the search after it has converged, and to recover coarse-grained informa tion about the space that was suppressed during convergence. The successful optimization of a complex function by SIGH usually in volves a series of such converge/diverge cycles.

INTERVENTION challenges two of the most sacred tenets of modern society, innovation and technology, from the perspective of the unique risks they present. Using genetic engineering as its model, it paints a vivid picture of the scientific uncertainties that biotech risk evaluations dismiss or ignore, and lays bare the power and money conflicts between academia, industry and regulators that have sped these risky innovations to the market. Intervention champions an alternative method for assessing the risks of technology, developed by the world's top risk experts, that can eliminate such conflicts, help regain public trust in science and government, and drive research and development toward more useful, safer products.

A crucial guide to life before—and after—Tinder, IVF, and robots. What will happen to our notions of marriage and parenthood as reproductive technologies increasingly allow for newfangled ways of creating babies? What will happen to our understanding of gender as medical advances enable individuals to transition from one set of sexual characteristics to another, or to remain happily perched in between? What will happen to love and sex and romance as our relationships migrate from the real world to the Internet? Can people fall in love with robots? Will they? In short, what will happen to our most basic notions of humanity as we entangle our lives and emotions with the machines we have created? In Work Mate Marry Love, Harvard Business School professor and former Barnard College president Debora L. Spar offers an incisive and provocative account of how technology has transformed our intimate lives in the past, and how it will do so again in the future. Surveying the course of history, she shows how marriage as we understand it resulted from the rise of agriculture, and that the nuclear family emerged with the industrial revolution. In their day, the street light, the car, and later the pill all upended courtship and sex. Now, as we enter an era of artificial intelligence and robots, how will our deepest feelings and attachments evolve? In the past, the prevailing modes of production produced a world dominated by heterosexual, mostly-monogamous, two-parent families. In the future, however, these patterns are almost certain to be reshaped, creating entirely new norms for sex and romance, and for the construction of families and the raising of children. Steering clear of both techno-euphoria and alarmism, Spar offers a bold and inclusive vision of how our lives might be changed for the better.

A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.