Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

A union list of serials commencing publication after Dec. 31, 1949.

This study is an outgrowth of our interest in the history of modern chemistry. The paucity of reliable, quantitative knowledge about past science was brought home forcibly to us when we undertook a research seminar in the comparative history of modern chemistry in Britain, Germany, and the United States. That seminar, which took place at the University of Pennsylvania in the spring of 1975, was paralleled by one devoted to the work of the "Annales School". The two seminars together catalyzed the attempt to construct historical measures of change in aspects of one science, or "chem ical indicators". The present volume displays our results. Perhaps our labors may be most usefully compared with the work of those students of medieval science who devote their best efforts to the establish ment of texts. Only when acceptable texts have been constructed from fragmentary and corrupt sources can scholars move on to the more satisfying business of making history. So too in the modern period, a necessary pre liminary to the full history of any scientific profession is the establishing of reliable quantitative information in the form of statistical series. This volume does not offer history. Instead it provides certain element- indicators -- that may be useful to individuals interested in the history of American chemistry and chemical industry, and suggestive for policy.