In order to try to initiate the development of a responsible regulatory framework for any eventual release of transgenic insects, the FAO, IAEA and IPPC convened a consultants meeting in Rome during 2002. This publication summarizes the deliberations of the group and provides full texts of the working papers.

Genetic engineering suggests new avenues for constructing useful products, but it also poses hazards to the health of the environment and the public. Delineating those hazards is complicated, difficult, and important at every level of risk assessment and risk management decision-making. Risk assessment and risk management may be further complicated

Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnologyâ€"key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effectsâ€"the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.

Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.

Technology for modifying the genotypes and phenotypes of insects and other arthropods has steadily progressed with the development of more precise and powerful methods, most prominently transgenic modification. For many insect pests, there is now almost unlimited ability to modify phenotypes to benefit human health and agriculture. Precise DNA modifications and gene drive have the power to make wild-type populations less harmful in ways that could never have been performed with previous transgenic approaches. This transition from primarily laboratory science to greater application for field use has also necessitated greater development of modeling, ethical considerations and regulatory oversight. The 2nd Edition of Transgenic Insects contains chapters contributed by experts in the field that cover technologies and applications that are now possible. This edition includes increased attention to associated challenges of risk assessment, regulation, and public engagement. This book will be very valuable to students and researchers in entomology, molecular biology, genetics, public health and agriculture, and will also appeal to practitioners who are implementing the technology, and to regulators, stakeholders and ethicists.

Insect Molecular Genetics

Biotechnology has contribute much to the field of insect pest management so far, from side to side development of transgenic plants and other novel ecofriendly products to manage insects. Recognition of the importance and relevance of biotechnological applications in insect control is gaining momentum. There is also improved interest among scientists in developing novel strategies for insect pest management. Realizing the possible benefits and constraints in the use of biotechnology in insect pest management, a national symposium on 'Biotechnology and Insect Pest Management' was organized freshly. Deliberations during the symposium covered various aspects such as insect resistant transgenic crops, microbial pesticides - process and development, botanical pesticides - process and development, hybridization techniques in the production of potential natural enemies, insect and animal vectors of diseases and biosafety concerns, etc. Genetic engineering has been used to enhance the insecticidal efficacy of various strains of Bt by increasing virulence, extending host range, and increasing field stability, and by introducing alternative toxins to facilitate resistance management. Techniques have been developed for production by genetic means of new strains of Bt with new combinations of toxin genes. Crop varieties resistant to insects are far less common than disease-resistant varieties, because plant breeders have traditionally focused more on disease resistance. However, if they are available, resistant varieties can be an effective defense against insect pests. But even when insect-resistant cultivars are not available, some varieties may be less attractive to pest species or may tolerate more damage than others. Plant size, shape, coloration, leaf hair, cuticle thickness, and natural chemicals (attractants and repellents) can all affect pest susceptibility. Farmers can do their own breeding by collecting non-hybrid seed from healthy plants in the field. Plants well adapted to local conditions will be more likely to resist pests. This book throws new light on alternative technologies to control insect pests. Scientists from different institutions from all over world have provided various biotechnology based techniques and other means to manage insect pests.

Drivers behind food security and crop protection issues vis-à-vis the food losses caused by pests include rapid human population increase, climate change, loss of beneficial on-farm biodiversity, reduction in per capita cropped land, water shortages, and pesticide withdrawals. Integrated pest management, therefore, becomes a compulsory strategy in agriculture, which offers a 'toolbox' of complementary crop- and region-specific crop protection solutions to address these rising pressures. IPM aims at more sustainable solutions by using complementary technologies and one of them is the use of biopesticides including genetically modified cropping systems. The aim is to reduce pests below economic thresholds utilizing key 'ecological services', particularly biocontrol systems via semiochemicals, biopesticides, precision pest monitoring tools, and rapid diagnostics. In fact, we are facing twin problems of environment and food security for the expanding population and it is necessary to ensure adequate pesticide-free food. The ecofriendly nature of biopesticide products suggests environment protection and safety for natural enemies and non-target organisms. However, their adoption and use have lagged behind due to certain constraints like variable performance under field situations, lack of quality standards and interest by big industrial houses, and cumbersome regulatory procedures. The present book is an attempt to critically debate over all these issues and suggest a road map for future.

Agricultural biotechnology takes many forms and applications, with the number and diversity of products ever increasing. With this rapid development, regulatory authorities have sought to keep pace through regulatory adjustments and advances to ensure the safe and beneficial use of this critical technology. The regulatory systems for the U.S. and Canada are not static and must evolve in order to maintain relevance, efficiency and applicability to the challenges encountered. The diverse authors, drawn from the biotechnology industry, academia, government research and regulatory agencies, offer their perspectives of the historical and current system and suggest where it can be improved in the future. Based upon vast experience interacting with the regulatory system, the editors and authors offer demystifying views of the US and Canadian regulatory structures and how they came to be. We know of no other effort to present the biotechnology regulatory systems of the US and Canada in an open forum which will benefit those in the regulated community as well as those charged with oversight of the products of biotechnology, and ultimately the consumer!