The most comprehensive, current sickle cell disease resource—for both clinicians and researchers A Doody's Core Title for 2023! The first and only resource of its kind, Sickle Cell Disease examines this blood disorder through both clinical and research lenses. More than 80 dedicated experts in the field present their combined clinical knowledge of basic mechanisms, screening, diagnosis, management, and treatment of myriad complex complications of a single base point mutation in the human genome. Case studies with “How I Treat” authoritative insights provide overviews of common and rare complications, and Key Facts offer at-a-glance high-yield information. Filled with clinical photos, illustrations, numerous original diagrams, and with free updates available online, this unmatched resource covers: Mechanisms of sickle cell disease Historic and current research approaches The latest work in gene therapy and editing Guidelines for patient care, diagnosis, unique cases, and therapies Rare and common complications, including domestic and internationally relevant topics Psychosocial and supportive care The newest standards of therapy and future treatment options in children and adults Cardiopulmonary complications

For the first time in nearly 100 years, The Sickle by William W Walter, Volume 1 is now available to the general public. This Metaphysical classic, as well as its companion volume, "The Sharp Sickle, A Text Book of Eschatology, Volume 2" were far ahead of their time when written and even now stands firmly on its feet among Christian Science practitioners as well as those with a deep interest in metaphysics and healing. Mr. Walter was known throughout the world through his teaching, healing and writing. He had many students from Canada, England, South Africa, New Zealand, Australia, and most every state in the United States. Wishing to give to the world the benefit of his finding he wrote a book entitled "The Sickle," which acted as a bridge between mind and matter and brought the readers' thought up gradually. After a few years of study of this book, he wrote "The Sharp Sickle," which became the text-book of Eschatology. AudioEnlightenment has done an incredible service in finding, and bringing these books to the attention of the public once again for those that seek truth wherever it presents itself. The Sickle, William W Walter, from the preface This book was written for the thinker, and not the trifler; it was not written to benefit the writer, but to enlighten the honest searcher for truth. The price was placed at twenty-five dollars to prevent its fall into the hands of the trifler, for the trifler takes paper and binding and size into consideration in determining the value of the book, the thinker scan the contents. To the trifler it would be dear at any price and to the actual thinker it would be cheap at any price. That large sales or financial gain were not the intent of the writer, should be evident. Were this true, the book would have been put on the market at the usual price. This is a metaphysical work, and therefore, the determination of its price was based upon the metaphysical (mental) viewpoint, --that the human mind values cheaply that which it estimates as cheap, but craves that which it finds difficulty in obtaining. Some honest thinkers may object to the price as being a bar to the worthy poor. It can be argued in reply that the family in humble circumstances usually succeeds in obtaining the necessary sum, were it twice twenty-five dollars, --to pay for a remedial appliance, electric belt, battery, etc., ordered or advised by the physician. This book is a mental battery, charged to its fullest capacity, not with lightning, but with enlightening true thought, or Truth, the true elixir of Life, and this current of true thought, rightly applied, will not heal body and mind merely, but the purse as well. This work should not be loaned to the trifler for he is not ready for the meat of the Word. He will not exert the necessary effort to understand it, and may therefore turn and rend you mentally for your ill-chosen charity. It is a mistaken kindness to loan it to the casual thinker. He will read it hurriedly and doubtless think that he has gained all the good contained therein through this hurried reading, whereas, if he had paid twenty-five dollars for a copy, he would be inclined to read it carefully and more than once. It is well to tell the earnest seeker about the book, or read a fitting chapter to him or permit him to read it in your presence, but to loan the book outright will in most cases tend to deprive the ones you wish to benefit, of the very good they would gain by their owning and studying it. In Matthew, chapter 7, verse 6, we read: "Give not that which is holy unto the dogs, neither cast ye your pearls before swine, lest they trample them under their feet, and turn again and rend you." The necessity for such strong language must have existed, else Jesus would not have used it. So use due caution in giving the plain truth, and thus save yourselves unnecessary rending by the narrow minded.

Ten years ago I placed "The Sickle" before the thinkers in a very careful and methodical manner; and for the past five years I have waited patiently (Did I say patiently? Well, sometimes rather impatiently), for the thought of the advanced thinkers to unfold so that I could put this book before them with the assurance that they were ready for the "last things," the actual science of actuality; and not merely a science of physical harmony. This book is not for general distribution at this time (1925), for the general public has not yet awakened to where they can appreciate the facts stated here. They, like those who have entered this work before them, will need to take the necessary preliminary steps; and through study of my lesser writings, or through being taught the lesser things by my teachers, unfold their thought to a state where this work can be assimilated, understood and demonstrated. The price I ask for this work does not interest the public at all, for it will not be sold to the public at this time; and those to whom it will be sold, will gladly give twice the price I ask for it. If there be some who would gladly pay the price but have it not, this is positive proof that they have not applied the primary lessons sufficiently; and consequently, are not ready for this work. I would advise such as these to spend their time on "The Sickle," until their thought regarding supply has been mastered and the necessary supply is bountifully forthcoming. In the science of Eschatology, fruitage is a sure sign of actual understanding. When Jesus told the multitude that henceforth they would need to work out their own salvation, that the free bread line was abolished, many turned their back on his leadership. Noting this, the Master Mind turned to his disciples and asked, "Will ye not also go away?" Then Simon Peter answered him saying, "Lord, to whom shall we go? Thou hast the words of eternal life." Simon Peter had some understanding of the actual; those who turned back had not. The same holds true to this day; and this should explain the actions of those who leave this science and go hither and thither seeking an easier way. This book, as well as the predecessor, The Sickle, have more or less been artificially suppressed for nearly 100 years. Now is the time for these volumes to be made available to the general public and those seeking the truth. As Walter states in the preface of The Sickle, these books are not for the trifler or those on a casual search. The journey is well worth the effort and the time is right with the expanding of human consciousness worldwide to re introduce these volumes into the collective consciousness. Enjoy the Journey Barry J Peterson, CEO, Audio Enlightenment

"Swing the Sickle for the Harvest Is Ripe" compares the work, family, and economic experiences of enslaved women and men in upcountry and lowland Georgia during the nineteenth century. Mining planters' daybooks, plantation records, and a wealth of other sources, Daina Ramey Berry shows how slaves' experiences on large plantations, which were essentially self-contained, closed communities, contrasted with those on small plantations, where planters' interests in sharing their workforce allowed slaves more open, fluid communications. By inviting readers into slaves' internal lives through her detailed examination of domestic violence, separation and sale, and forced breeding, Berry also reveals important new ways of understanding what it meant to be a female or male slave, as well as how public and private aspects of slave life influenced each other on the plantation.

Sickle cell disease can be severe and disabling. When properly treated, patients live longer and with better quality life. This is a US government publication intended to provide evidence-based guidelines for the care of these patients for the use of all concerned providers as well as patients and family members. This book is available in print here for convenience.

Norway. The 1800s. Endre must to take over the family farm from his father--his father, who swings the sickle and sharpens the scythe, and says this is the only way in which rocks and stones and mounts and waves can still be ours. But Endre is strange, he keeps to himself, unlike his brothers who are merry and full of joy. He wants to live in the farm without longing to leave, but he is struggling. Then he meets Abelone--"the bearer of light." Tall and thin, always sitting with her books, sharper than all she went to school with, she is about to be a teacher. They appear to come from different worlds--one from the ancient, traditional, natural world; the other from the forward-looking world of modernity, of breaking away, and of renewal. But there is love--great and immediate. With new ideas and new languages, Abelone opens up the world of Endre--whose name means "change." A novel written in lyrical verse, Ruth Lillegraven's Sickle is an unforgettable evocation of longing and loss, of dreams and reality, and the importance of language itself.

Ferdinandus Van Sycklin (ca. 1635-ca. 1712) emigrated from Holland, Netherlands to Kings County, Long Island, New York in 1652. He married Eva Antonis Jansen about 1660, and settled as pioneers on Long Island. Descendants (chiefly spelling surname Van Sicklen or or Van Sickle) and relatives lived in New York, New Jersey, Ohio, Indiana, Wisconsin, Minnesota and elsewhere.

Can a two-career couple really pick up stakes and move to Provence?Keith and Val had a dream ? to live in Provence, the land of brilliant sunlight, charming hilltop villages and the deep blue waters of the Mediterranean.But there were two problems: they weren't French speakers and they had full-time jobs. So they came up with a plan?Follow their adventures (and misadventures) as they quit their jobs, become consultants and split their time between two countries. Laugh along as they build a life in Provence, slowly mastering a new language and making friends with the locals over long meals and just a bit too much wine.This light and breezy memoir is full of wry observations on France, like the power of cheese to sway elections, the right and wrong ways for men to kiss each other, and the law requiring that blood donors must speak French.If you've ever dreamed of changing gears and learning what joie de vivre is really all about, you won't want to miss this delightful book.

When Battle of the Bulge veteran, Woody Wilson, realizes that Alzheimer's is about to ground him forever, he goes on the run. While the police, his wife of sixty years, and his only son search for him, a diabolical mystery man from Woody's past tracks him down and kidnaps him. He escapes his captor only to find himself facing an automatic life sentence in a criminal justice system gone haywire. Thrown into events he neither controls nor understands, he demonstrates in his last heroic battle the depth of his inner resolve never to fail those he loves. The Sickle's Compass, Stephen Woodfin's fourth novel, is a fast-paced legal thriller, a poignant story of threadbare yet resilient love, and a scathing indictment of America's refusal to make preparation for the coming tsunami: Alzheimer's Disease.