The explosive growth of organoselenium chemistry over the past 12 years can be attributed to the specific properties of organic selenium molecules, which fit the requirements of modern organic synthesis. Most of them are well adapted to chemo-, regio- and stereo-selectivities. In addition, they can be used in mild experimental conditions which are compatible with the stability of both substrates and products in the preparation of unsaturated and functional complex molecules, especially in the field of natural products. This book describes and illustrates different synthetic routes to organic structures using selenium reagents or intermediates. The approach emphasizes that such transformations are simple, efficient and often carried out at room temperature. The scope ranges from the preparation of both inorganic and organic selenium reagents, through descriptions of structure, toxicity, biological aspects and nuclear magnetic resonance, to applications of specific selenium compounds in various syntheses including natural products and biologically active compounds.

Embarking on a new millennium, the book in hands describes the recent developments of organsoselenium chemistry in all facets. Various distinguished scientists have contributed, with their skill and expertise, making this book a valuable source for synthetic oriented organic chemists and for those, who want to get a first insight into the chemistry of selenium.

Selenium and Tellurium Reagents provides an in-depth overview of recent advances on the chemistry of these elements. Written by internationally recognized experts, it gives insight into the synthesis, structure, analysis and mechanistic studies of these compounds. The book is organized into four parts which reflect the applications of Se and Te reagents in four areas: inorganic chemistry, organic chemistry, materials science and biochemistry.

The explosive growth of organoselenium chemistry over the past 12 years can be attributed to the specific properties of organic selenium molecules, which fit the requirements of modern organic synthesis. Most of them are well adapted to chemo-, regio- and stereo-selectivities. In addition, they can be used in mild experimental conditions which are compatible with the stability of both substrates and products in the preparation of unsaturated and functional complex molecules, especially in the field of natural products. This book describes and illustrates different synthetic routes to organic structures using selenium reagents or intermediates. The approach emphasizes that such transformations are simple, efficient and often carried out at room temperature. The scope ranges from the preparation of both inorganic and organic selenium reagents, through descriptions of structure, toxicity, biological aspects and nuclear magnetic resonance, to applications of specific selenium compounds in various syntheses including natural products and biologically active compounds.

This book presents recent advances in and perspectives on the use of organoselenium compounds, primarily highlighting the new frontiers in the field of Green Chemistry, their therapeutic and biological relevance and new materials. Throughout its 200 pages, readers will find an updated and comprehensive review of new aspects of organoselenium chemistry and biochemistry. Fully referenced and written in an easy to read style, it offers readers a primary resource for including organoselenium derivatives in their projects. This book will be of interest to specialists, students and researchers involved in a broad range of fields, from synthetic green chemistry to medicinal chemistry and the chemistry of natural products. The connection between organoselenium compounds and green chemistry, despite having only recently emerged, is one of the subjects of this book. The first chapter highlights the use of Se-containing molecules as reagents and catalysts in new green protocols to access important organic transformations. The book provides a wealth of examples of bioactive Se-containing molecules, especially focusing on those with potential therapeutic uses. The second chapter focuses on the state of the art concerning the role of organoselenium compounds as antioxidants, GPx mimics, and derivatives endowed with different bioactive properties. “Organoselenium in nature” is the title of the third chapter, which equips readers with essential information on the main natural organoselenium compounds and where they are found. Selected aspects of the metabolism of selenium in plants and microorganisms are also discussed. In closing, the book includes a chapter dedicated to recent advances concerning the nonbonding interactions between organochalcogen compounds. This is currently a hot topic in selenium chemistry and biochemistry, and here readers will find key insights into the chalcogen bond and its role in the biological activity of organoselenium compounds.

Selenium-based methods in synthetic chemistry have developed rapidly over the past years and are now offering highly useful tools for organic synthesis. Filling the gap for a comprehensive handbook and ready reference, this book covers all modern developments within the field, including biochemical aspects. The chemistry chapters are organized according to the different reactivities of various selenium compounds and reagents, with each chapter dealing with a special reaction type. Also includes a table with 77Se NMR shifts to aid in practical problems. From the Contents: * Electrophilic and Nucleophilic Selenium * Selenium Compounds in Radical Reactions * Selenium-Stabilized Carbanions * Selenium Compounds with Valency Higher than Two * Selenocarbonyls * Selenoxide Elimination and [2,3]-Sigmatropic Rearrangement * Selenium Compounds as Ligands and Catalysts * Biological and Biochemical Aspects of Selenium Compounds

The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part A covers fundamental structural topics and basic mechanistic types. It can stand-alone; together, with Part B: Reaction and Synthesis, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for study of structure, reaction and selectivity for students and exercise solutions for instructors.

The increasing number of publications that use tellurium clearly demonstrates the important role of tellurium compounds as unique and powerful tools in a broad range of organic chemical manipulations, often characterized by their selective behavior. Tellurium in Organic Synthesis provides an overview of the principal aspects of organic tellurium chemistry. Many chapters have been enriched and updated in this second edition. New chapters include overviews of toxicology and pharmacology and a review on the preparation and reactivity of several tellurium heterocycles. The first part of the book focuses on the preparation of selected inorganic tellurium compounds and on the main classes of organotellurium compounds. The second part, and main interest of the book, details the use of these inorganic and organic compounds as reagents to perform specific organic manipulations and synthesis. Reactions covered include reduction, formation and reaction of anionic species, deprotection, tellurium cyclizations, formation of alkenes, use of vinyllic tellurides, free radical chemistry, transmetallations, and removal of tellurium. - Overview of inorganic and organic tellurium chemistry - Synthetic applications of tellurium compounds - All topics accompanied by detailed experimental procedures

This book is about the recognition of new principles in Organic Chemistry. It is also about the discovery and invention of Chemical Reactions. In addition, it deals with the determination of structure by chemical degradation during the epoch when physical methods were not well developed. Also presented are new reagents and new types of functional groups never seen in chemistry before. The overall aim of the collected papers is to show how thought can direct original research and to demonstrate how thought about old or new chemical facts can lead to originality. This is further illuminated by commentaries which Prof Barton has written to accompany these papers.

Organoselenium chemistry is proving increasingly valuable to the synthetic organic chemist. Selenium residues are easily introduced into organic molecules, they serve to effect a variety of useful transformations, and are easily removed at the end of the sequence. These processes are often characterized by high chemo- regio- and stereoselectivity. Recent enantioselective variations of selenium-mediated reactions are further extending their scope and utility. The use of organoselenium compounds in organic conductors is another area of intense current interest. Organoselenium Chemistry - A Practical Approach is written by an international group of experts in the field.