Rna As A Drug Target
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Author |
: John Schneekloth |
Publisher |
: John Wiley & Sons |
Total Pages |
: 418 |
Release |
: 2024-10-07 |
ISBN-10 |
: 9783527351008 |
ISBN-13 |
: 3527351000 |
Rating |
: 4/5 (08 Downloads) |
Synopsis RNA as a Drug Target by : John Schneekloth
Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete “toolbox” for working with RNA, from structure determination to screening and lead generation techniques A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry.
Author |
: Paloma H. Giangrande |
Publisher |
: Academic Press |
Total Pages |
: 474 |
Release |
: 2022-04-10 |
ISBN-10 |
: 9780128217399 |
ISBN-13 |
: 0128217391 |
Rating |
: 4/5 (99 Downloads) |
Synopsis RNA Therapeutics by : Paloma H. Giangrande
RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. - Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies - Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics - Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects
Author |
: Stanley T. Crooke |
Publisher |
: CRC Press |
Total Pages |
: 848 |
Release |
: 2007-07-25 |
ISBN-10 |
: 9781439832509 |
ISBN-13 |
: 1439832501 |
Rating |
: 4/5 (09 Downloads) |
Synopsis Antisense Drug Technology by : Stanley T. Crooke
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati
Author |
: Steven T. Runyon |
Publisher |
: |
Total Pages |
: 468 |
Release |
: 2002 |
ISBN-10 |
: UCAL:X67935 |
ISBN-13 |
: |
Rating |
: 4/5 (35 Downloads) |
Synopsis RNA as a Drug Target by : Steven T. Runyon
Author |
: Olga N. Ilinskaya |
Publisher |
: Frontiers Media SA |
Total Pages |
: 251 |
Release |
: 2020-06-04 |
ISBN-10 |
: 9782889637751 |
ISBN-13 |
: 2889637751 |
Rating |
: 4/5 (51 Downloads) |
Synopsis New Advances in RNA Targeting by : Olga N. Ilinskaya
Author |
: Michael J Gait |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 566 |
Release |
: 2019-02-11 |
ISBN-10 |
: 9781788012096 |
ISBN-13 |
: 1788012097 |
Rating |
: 4/5 (96 Downloads) |
Synopsis Advances in Nucleic Acid Therapeutics by : Michael J Gait
The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.
Author |
: Paul H. Johnson |
Publisher |
: John Wiley & Sons |
Total Pages |
: 375 |
Release |
: 2011-03-01 |
ISBN-10 |
: 9780470934678 |
ISBN-13 |
: 0470934670 |
Rating |
: 4/5 (78 Downloads) |
Synopsis RNA Interference by : Paul H. Johnson
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
Author |
: Amanda L. Garner |
Publisher |
: Springer |
Total Pages |
: 263 |
Release |
: 2017-09-26 |
ISBN-10 |
: 9783319680910 |
ISBN-13 |
: 3319680919 |
Rating |
: 4/5 (10 Downloads) |
Synopsis RNA Therapeutics by : Amanda L. Garner
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author |
: |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2002 |
ISBN-10 |
: 0815332181 |
ISBN-13 |
: 9780815332183 |
Rating |
: 4/5 (81 Downloads) |
Synopsis Molecular Biology of the Cell by :
Author |
: Edward D. Zanders |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 396 |
Release |
: 2011-07-08 |
ISBN-10 |
: 9781441999023 |
ISBN-13 |
: 1441999027 |
Rating |
: 4/5 (23 Downloads) |
Synopsis The Science and Business of Drug Discovery by : Edward D. Zanders
The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the nineteen chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators.