Pyrrhic Progress analyses over half a century of antibiotic use, regulation, and resistance in US and British food production. Mass-introduced after 1945, antibiotics helped revolutionize post-war agriculture. Food producers used antibiotics to prevent and treat disease, protect plants, preserve food, and promote animals' growth. Many soon became dependent on routine antibiotic use to sustain and increase production. The resulting growth of antibiotic infrastructures came at a price. Critics blamed antibiotics for leaving dangerous residues in food, enabling bad animal welfare, and selecting for antimicrobial resistance (AMR) in bacteria, which could no longer be treated with antibiotics. Pyrrhic Progress reconstructs the complicated negotiations that accompanied this process of risk prioritization between consumers, farmers, and regulators on both sides of the Atlantic. Unsurprisingly, solutions differed: while Europeans implemented precautionary antibiotic restrictions to curb AMR, consumer concerns and cost-benefit assessments made US regulators focus on curbing drug residues in food. The result was a growing divergence of antibiotic stewardship and a rise of AMR. Kirchhelle's comprehensive analysis of evolving non-human antibiotic use and the historical complexities of antibiotic stewardship provides important insights for current debates on the global burden of AMR.

Winner of the 2021 Joan Thirsk Memorial Prize from the British Agricultural History Society​ 2020 Choice​ Outstanding Academic Title​ Winner of the 2020 Turriano Prize from ICOHTEC Short-listed and highly commended for the Antibiotic Guardian Award from Public Health England​ Long-listed for the Michel Déon Prize from the Royal Irish Academy​ Pyrrhic Progress analyses over half a century of antibiotic use, regulation, and resistance in US and British food production. Mass-introduced after 1945, antibiotics helped revolutionize post-war agriculture. Food producers used antibiotics to prevent and treat disease, protect plants, preserve food, and promote animals’ growth. Many soon became dependent on routine antibiotic use to sustain and increase production. The resulting growth of antibiotic infrastructures came at a price. Critics blamed antibiotics for leaving dangerous residues in food, enabling bad animal welfare, and selecting for antimicrobial resistance (AMR) in bacteria, which could no longer be treated with antibiotics. Pyrrhic Progress reconstructs the complicated negotiations that accompanied this process of risk prioritization between consumers, farmers, and regulators on both sides of the Atlantic. Unsurprisingly, solutions differed: while Europeans implemented precautionary antibiotic restrictions to curb AMR, consumer concerns and cost-benefit assessments made US regulators focus on curbing drug residues in food. The result was a growing divergence of antibiotic stewardship and a rise of AMR. Kirchhelle’s comprehensive analysis of evolving non-human antibiotic use and the historical complexities of antibiotic stewardship provides important insights for current debates on the global burden of AMR. This Open Access ebook is available under a CC-BY-NC-ND license, and is supported by a generous grant from Wellcome Trust.

In the early 1990s, Russian President Boris Yeltsin revealed that for the previous thirty years the Soviet Union had dumped vast amounts of dangerous radioactive waste into rivers and seas in blatant violation of international agreements. The disclosure caused outrage throughout the Western world, particularly since officials from the Soviet Union had denounced environmental pollution by the United States and Britain throughout the cold war. Poison in the Well provides a balanced look at the policy decisions, scientific conflicts, public relations strategies, and the myriad mishaps and subsequent cover-ups that were born out of the dilemma of where to house deadly nuclear materials. Why did scientists and politicians choose the sea for waste disposal? How did negotiations about the uses of the sea change the way scientists, government officials, and ultimately the lay public envisioned the oceans? Jacob Darwin Hamblin traces the development of the issue in Western countries from the end of World War II to the blossoming of the environmental movement in the early 1970s. This is an important book for students and scholars in the history of science who want to explore a striking case study of the conflicts that so often occur at the intersection of science, politics, and international diplomacy.

The lives of four high school seniors intersect weeks before a meteor is set to pass through Earth's orbit, with a 66.6% chance of striking and destroying all life on the planet.

With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.

In the pantheon of air power spokesmen, Giulio Douhet holds center stage. His writings, more often cited than perhaps actually read, appear as excerpts and aphorisms in the writings of numerous other air power spokesmen, advocates-and critics. Though a highly controversial figure, the very controversy that surrounds him offers to us a testimonial of the value and depth of his work, and the need for airmen today to become familiar with his thought. The progressive development of air power to the point where, today, it is more correct to refer to aerospace power has not outdated the notions of Douhet in the slightest In fact, in many ways, the kinds of technological capabilities that we enjoy as a global air power provider attest to the breadth of his vision. Douhet, together with Hugh “Boom” Trenchard of Great Britain and William “Billy” Mitchell of the United States, is justly recognized as one of the three great spokesmen of the early air power era. This reprint is offered in the spirit of continuing the dialogue that Douhet himself so perceptively began with the first edition of this book, published in 1921. Readers may well find much that they disagree with in this book, but also much that is of enduring value. The vital necessity of Douhet’s central vision-that command of the air is all important in modern warfare-has been proven throughout the history of wars in this century, from the fighting over the Somme to the air war over Kuwait and Iraq.

The revolution was not the beginning of agriculture but the beginning of agriculture on a large scale, in one place, with refined tools. Tudge offers a persuasive hypothesis about a puzzling epoch, along the way providing new insights into the Pleistocene overkill, the demise of the Neanderthals, the location of the biblical Eden, and much more."--BOOK JACKET.

During the latter half of the twentieth century, federal funding in the United States for scientific research and development increased dramatically. Yet despite the infusion of public funds into research centers, the relationship between public policy and research and development remains poorly understood. How does the federal government attempt to harness scientific knowledge and resources for the nation's economic welfare and competitiveness in the global marketplace? Who makes decisions about controversial scientific experiments, such as genetic engineering and space exploration? Who is held accountable when things go wrong? In this lucidly-written introduction to the topic, Sylvia Kraemer draws upon her extensive experience in government to develop a useful and powerful framework for thinking about the American approach to shaping and managing scientific innovation. Kraemer suggests that the history of science, technology, and politics is best understood as a negotiation of ongoing tensions between open and closed systems. Open systems depend on universal access to information that is complete, verifiable, and appropriately used. Closed systems, in contrast, are composed of unique and often proprietary features, which are designed to control usage. From the Constitution's patent clause to current debates over intellectual property, stem cells, and internet regulation, Kraemer shows the promise-as well as the limits-of open systems in advancing scientific progress as well as the nation's economic vitality.

The history of medicine is much more than the story of doctors, nurses, and hospitals. Seeking to understand the patient's perspective, historians scour the archives, searching for rare personal accounts. Bringing together a trove of more than 400 family letters by Charles Dwight Willard, Suffering in the Land of Sunshine provides a unique window into the experience of sickness. A Los Angeles civic leader at the turn of the twentieth century, Willard is well known to historians of the West, but exclusively for his public life as a booster and reformer. Willard's evocative story offers fresh insights into several critical issues, including how concepts of gender, class, and race shape patients' representations of their illness, how expectations of cure affect the illness experience, how different cultures constrain the coping strategies of the sick, and why robust health is such an exalted value in certain societies.