This guide presents information on planning and managing microfilming projects, incorporating co-operative programmes, service bureaux and the impact of automation for library staff with deteriorating collections.

This volume highlights recent research efforts in the conservation and investigation of works of art on wood. Through eleven case studies it showcases different experimental methods ranging from X-ray analysis of objects to the study of cross-sections made from micro-samples. New research focusing on the technical study, treatment and assessment of works of art on wood in its many forms is featured in this edited volume. Technical studies include the attribution and investigations of a triptych by Hans Memling and a sculpture from workshop of Michel and Gregor Erhart, decorated Syrian rooms, and investigations of finely carved Gothic wooden objects. Synchrotron-based methods are presented for studying the alteration of 19th c. verdigris in Norway, and multi-analytical methods are employed for the investigations of 16th to 19th c. East Asian lacquer from the Kunsthistorisches Museum in Vienna. Novel methods for the cleaning of gilded surfaces using gels and emulsions are shown, as are innovative strategies for the consolidation for waterlogged wood, providing key data for the assessment of risks and benefits of new methods, and the short and long-term effects on gilding layers and archaeological wood. The book clearly shows how collaboration between engineers, physicists, biologists and chemists and conservators of different types of materials can lead to new research in conservation science. This book is crucial reading for conservators and conservation scientists, as well as for technical art historians, providing key methodological case studies of polychromy from different temporal and geographical contexts.

This is an investigation into the extent of student mobility in and out of 32 European countries for the purposes of higher education. The authors present and analyse mobility statistics and also make recommendations for the improvement of future data collection techniques in order that they more accurately reflect distinctions between various types of international students.

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. - Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands - Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease - Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

PART I. Optical Biosensors: The Present -- Chapter 1. Optrode-based Fiber Optic Biosensors -- Israel Biran and David R. Walt -- Chapter 2. Evanescent Wave Fiber Optic Biosensors -- Chris Rowe Taitt and Frances S. Ligler -- Chapter 3. Planar Waveguides for Fluorescence Biosensors -- Kim Sapsford, Chris Rowe Taitt, and Frances S. Ligler -- Chapter 4. Flow Immnosensor -- Anne W. Kusterbeck -- Chapter 5. Time Resolved Fluorescence -- Richard Thompson -- Chapter 6. Electrochemiluminescence -- Mark M. Richter -- Chapter 7. Surface Plasmon Resonance Biosensors -- Jiri Homola, Sinclair Yee, and David Myszka -- Chapter 8. The Resonant Mirror Optical Biosensor -- Tim Kinning and Paul Edwards -- Chapter 9. Interferometric Biosensors -- Daniel P. Campbell and Candice J. McCloskey -- Part II. Optical Biosensors: The Future -- Chapter 10. Genetic Engineering of Signaling Molecules -- Agatha Feltus and Sylvia Daunert -- Chapter 11. Artificial Receptors for Chemosensors -- Thomas W. Bell and Nicholas ...

Providing in-depth information on how to obtain high-performance materials by controlling their nanostructures, this ready reference covers both the bottom-up and the top-down approaches to the synthesis and processing of nanostructured materials. The focus is on advanced methods of mechanical nanostructuring such as severe plastic deformation, including high pressure torsion, equal channel angular processing, cyclic extrusion compression, accumulative roll bonding, and surface mechanical attrition treatment. As such, the contents are inherently application-oriented, with the methods presented able to be easily integrated into existing production processes. In addition, the structure-property relationships and ways of influencing the nanostructure in order to exhibit a desired functionality are reviewed in detail. The whole is rounded off by a look at future directions, followed by an overview of applications in various fields of structural and mechanical engineering. With its solutions for successful processing of complex-shaped workpieces and large-scale specimens with desired properties, this is an indispensable tool for purposeful materials design.

One of the major challenges of modern biology and medicine consists in finding means to visualize biomolecules in their natural environment with the greatest level of accuracy, so as to gain insight into their properties and behaviour in a physiological and pathological setting. This has been achieved thanks to the design of novel imaging agents, in particular to fluorescent biosensors. Fluorescence Biosensors comprise a large set of tools which are useful for fundamental purposes as well as for applications in biomedicine, drug discovery and biotechnology. These tools have been designed and engineered thanks to the combined efforts of chemists and biologists over the last decade, and developed hand in hand together with imaging technologies. This volume will convey the many exciting developments the field of fluorescent biosensors and reporters has witnessed over the recent years, from concepts to applications, including chapters on the chemistry of fluorescent probes, on technologies for monitoring protein/protein interactions and technologies for imaging biosensors in cultured cells and in vivo. Other chapters are devoted to specific examples of genetically-encoded reporters, or to protein and peptide biosensors, together with examples illustrating their application to cellular and in vivo imaging, biomedical applications, drug discovery and high throughput screening. - Contributions from leading authorities - Informs and updates on all the latest developments in the field

Recognition of the potentially deleterious implications of inequality in opportunity originating in a skewed asset distribution has spawned considerable interest in land reforms. However, little attention has been devoted to the fact that, in the longer-term, the measures used to implement land reforms, especially rental restrictions, could negatively affect productivity. Use of state level data on rental restrictions, together with a nationally representative survey from India suggests that, contrary to original intentions, rental restrictions negatively affect productivity and equity by reducing scope for efficiency-enhancing rental transactions that benefit poor producers. Simulations suggest that, by doubling the number of producers with access to land through rental, from about 15 million currently, liberalization of rental markets could have far-reaching impacts.

A guidebook for hikers, bikers, and equestrians, Hiking from Portland to the Coast explores the many trails and logging roads that crisscross the northern portion of Oregon's Coast Range. Designed to showcase convenient "looped" routes, it also describes complete throughways connecting Portland to the coastal communities of Seaside and Tillamook. Each of the 30 trails described includes a backstory to help users appreciate the history and significance of the places through which they are traveling.

Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment. - Contains contributions from leading authorities on the topic - Publishes cutting-edge reviews in molecular biology - Informs and updates on all the latest developments available regarding the research of gonadotropins