In this book, we embark on a journey into the realm of predictive data modeling for biomedical data and imaging in healthcare. It explores the potential of predictive analytics in the field of medical science through utilizing various tools and techniques to unravel insights and enhance patient care. This volume creates a medium for an interchange of knowledge from expertise and concerns in the field of predictive data modeling. In detail, the research work on this will include the effective use of predictive data modeling algorithms to run image analysis tasks for understanding. Predictive Data Modelling for Biomedical Data and Imaging is divided into three sections, namely Section I – Beginning of Predictive Data Modeling for Biomedical Data and Imaging/Healthcare, Section II – Data Design and Analysis for Biomedical Data and Imaging/Healthcare, and Section III – Case Studies of Predictive Analytics for Biomedical Data and Imaging/Healthcare. We hope this book will inspire further research and innovation in the field of predictive data modeling for biomedical data and imaging in healthcare. By exploring diverse case studies and methodologies, this book contributes to the advancement of healthcare practices, ultimately improving patient outcomes and well-being.

Predictive Modeling in Biomedical Data Mining and Analysis presents major technical advancements and research findings in the field of machine learning in biomedical image and data analysis. The book examines recent technologies and studies in preclinical and clinical practice in computational intelligence. The authors present leading-edge research in the science of processing, analyzing and utilizing all aspects of advanced computational machine learning in biomedical image and data analysis. As the application of machine learning is spreading to a variety of biomedical problems, including automatic image segmentation, image classification, disease classification, fundamental biological processes, and treatments, this is an ideal reference. Machine Learning techniques are used as predictive models for many types of applications, including biomedical applications. These techniques have shown impressive results across a variety of domains in biomedical engineering research. Biology and medicine are data-rich disciplines, but the data are complex and often ill-understood, hence the need for new resources and information. - Includes predictive modeling algorithms for both Supervised Learning and Unsupervised Learning for medical diagnosis, data summarization and pattern identification - Offers complete coverage of predictive modeling in biomedical applications, including data visualization, information retrieval, data mining, image pre-processing and segmentation, mathematical models and deep neural networks - Provides readers with leading-edge coverage of biomedical data processing, including high dimension data, data reduction, clinical decision-making, deep machine learning in large data sets, multimodal, multi-task, and transfer learning, as well as machine learning with Internet of Biomedical Things applications

Overview of biomedical data science -- Spreadsheet tools and tips -- Biostatistics primer -- Data visualization -- Introduction to databases -- Big data -- Bioinformatics and precision medicine -- Programming languages for data analysis -- Machine learning -- Artificial intelligence -- Biomedical data science resources -- Appendix A: Glossary -- Appendix B: Using data.world -- Appendix C: Chapter exercises.

The second edition of this volume provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but a sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice. There is an increasing need for personalized evidence-based medicine that uses an individualized approach to medical decision-making. In this Big Data era, there is expanded access to large volumes of routinely collected data and an increased number of applications for prediction models, such as targeted early detection of disease and individualized approaches to diagnostic testing and treatment. Clinical Prediction Models presents a practical checklist that needs to be considered for development of a valid prediction model. Steps include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formatting. The text also addresses common issues that make prediction models suboptimal, such as small sample sizes, exaggerated claims, and poor generalizability. The text is primarily intended for clinical epidemiologists and biostatisticians. Including many case studies and publicly available R code and data sets, the book is also appropriate as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. While practical in nature, the book also provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. Updates to this new and expanded edition include: • A discussion of Big Data and its implications for the design of prediction models • Machine learning issues • More simulations with missing ‘y’ values • Extended discussion on between-cohort heterogeneity • Description of ShinyApp • Updated LASSO illustration • New case studies

This textbook integrates important mathematical foundations, efficient computational algorithms, applied statistical inference techniques, and cutting-edge machine learning approaches to address a wide range of crucial biomedical informatics, health analytics applications, and decision science challenges. Each concept in the book includes a rigorous symbolic formulation coupled with computational algorithms and complete end-to-end pipeline protocols implemented as functional R electronic markdown notebooks. These workflows support active learning and demonstrate comprehensive data manipulations, interactive visualizations, and sophisticated analytics. The content includes open problems, state-of-the-art scientific knowledge, ethical integration of heterogeneous scientific tools, and procedures for systematic validation and dissemination of reproducible research findings. Complementary to the enormous challenges related to handling, interrogating, and understanding massive amounts of complex structured and unstructured data, there are unique opportunities that come with access to a wealth of feature-rich, high-dimensional, and time-varying information. The topics covered in Data Science and Predictive Analytics address specific knowledge gaps, resolve educational barriers, and mitigate workforce information-readiness and data science deficiencies. Specifically, it provides a transdisciplinary curriculum integrating core mathematical principles, modern computational methods, advanced data science techniques, model-based machine learning, model-free artificial intelligence, and innovative biomedical applications. The book’s fourteen chapters start with an introduction and progressively build foundational skills from visualization to linear modeling, dimensionality reduction, supervised classification, black-box machine learning techniques, qualitative learning methods, unsupervised clustering, model performance assessment, feature selection strategies, longitudinal data analytics, optimization, neural networks, and deep learning. The second edition of the book includes additional learning-based strategies utilizing generative adversarial networks, transfer learning, and synthetic data generation, as well as eight complementary electronic appendices. This textbook is suitable for formal didactic instructor-guided course education, as well as for individual or team-supported self-learning. The material is presented at the upper-division and graduate-level college courses and covers applied and interdisciplinary mathematics, contemporary learning-based data science techniques, computational algorithm development, optimization theory, statistical computing, and biomedical sciences. The analytical techniques and predictive scientific methods described in the book may be useful to a wide range of readers, formal and informal learners, college instructors, researchers, and engineers throughout the academy, industry, government, regulatory, funding, and policy agencies. The supporting book website provides many examples, datasets, functional scripts, complete electronic notebooks, extensive appendices, and additional materials.

This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.

Predictive Intelligence in Biomedical and Health Informatics focuses on imaging, computer-aided diagnosis and therapy as well as intelligent biomedical image processing and analysis. It develops computational models, methods and tools for biomedical engineering related to computer-aided diagnostics (CAD), computer-aided surgery (CAS), computational anatomy and bioinformatics. Large volumes of complex data are often a key feature of biomedical and engineering problems and computational intelligence helps to address such problems. Practical and validated solutions to hard biomedical and engineering problems can be developed by the applications of neural networks, support vector machines, reservoir computing, evolutionary optimization, biosignal processing, pattern recognition methods and other techniques to address complex problems of the real world.

Data Analytics in Biomedical Engineering and Healthcare explores key applications using data analytics, machine learning, and deep learning in health sciences and biomedical data. The book is useful for those working with big data analytics in biomedical research, medical industries, and medical research scientists. The book covers health analytics, data science, and machine and deep learning applications for biomedical data, covering areas such as predictive health analysis, electronic health records, medical image analysis, computational drug discovery, and genome structure prediction using predictive modeling. Case studies demonstrate big data applications in healthcare using the MapReduce and Hadoop frameworks. - Examines the development and application of data analytics applications in biomedical data - Presents innovative classification and regression models for predicting various diseases - Discusses genome structure prediction using predictive modeling - Shows readers how to develop clinical decision support systems - Shows researchers and specialists how to use hybrid learning for better medical diagnosis, including case studies of healthcare applications using the MapReduce and Hadoop frameworks

This book constitutes the refereed proceedings of the First International Conference on Bioengineering and Biomedical Signal and Image Processing, BIOMESIP 2021, held in Meloneras, Gran Canaria, Spain, in July 2021. The 41 full and 5 short papers were carefully reviewed and selected from 121 submissions. The papers are grouped in topical issues on biomedical applications in molecular, structural, and functional imaging; biomedical computing; biomedical signal measurement, acquisition and processing; computerized medical imaging and graphics; disease control and diagnosis; neuroimaging; pattern recognition and machine learning for biosignal data; personalized medicine; and COVID-19.

This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.