Most ecological risk assessments consider the risk to individual organisms or organism-level attributes. From a management perspective, however, risks to population-level attributes and processes are often more relevant. Despite many published calls for population risk assessment and the abundance of available scientific research and technical tool

Most ecological risk assessments consider the risk to individual organisms or organism-level attributes. From a management perspective, however, risks to population-level attributes and processes are often more relevant. Despite many published calls for population risk assessment and the abundance of available scientific research and technical tool

Recently, environmental scientists have been required to perform a new type of assessment-ecological risk assessment. This is the first book that explains how to perform ecological risk assessments and gives assessors access to the full range of useful data, models, and conceptual approaches they need to perform an accurate assessment. It explains how ecological risk assessment relates to more familiar types of assessments. It also shows how to organize and conduct an ecological risk assessment, including defining the source, selecting endpoints, describing the relevant features of the receiving environment, estimating exposure, estimating effects, characterizing the risks, and interacting with the risk manager. Specific technical topics include finding and selecting toxicity data; statistical and mathematical models of effects on organisms, populations, and ecosystems; estimation of chemical fate parameters; modeling of chemical transport and fate; estimation of chemical uptake by organisms; and estimation, propagation, and presentation of uncertainty. Ecological Risk Assessment also covers conventional risk assessments, risk assessments for existing contamination, large scale problems, exotic organisms, and risk assessments based on environmental monitoring. Environmental assessors at regulatory agencies, consulting firms, industry, and government labs need this book for its approaches and methods for ecological risk assessment. Professors in ecology and other environmental sciences will find the book's practical preparation useful for classroom instruction. Environmental toxicologists and chemists will appreciate the discussion of the utility for risk assessment of particular toxicity tests and chemical determinations.

Most ecological risk assessments consider the risk to individual organisms or organism-level attributes. From a management perspective, however, risks to population-level attributes and processes are often more relevant. Despite many published calls for population risk assessment and the abundance of available scientific research and technical tools assessing risks to populations, risk assessors worldwide still have difficulty determining how population level considerations can be integrated into environmental decision-making. Population-Level Ecological Risk Assessment establishes a framework for goals, methods, and data needs for different assessment applications and for integrating population-level risk assessment into risk management decisions. Beginning with a summary of legal, regulatory, business, and other contexts, the book presents population-level ecological risk assessment as an internationally recognized, science-based tool and offers specific recommendations for using this tool to support environmental management decisions. It gives clear, explicit, operational population assessment definitions and explains the relevance of density dependence, genetics, and spatial considerations, as well as applicable lessons from conservation biology and natural resource management. The authors provide a "tool box" of empirical and modeling methods and describe the general approaches, assumptions, data requirements, strengths, and limitations of each method. They establish a working foundation for designing and conducting population-level ecological risk assessments consistent with North American, European, and Japanese risk management approaches. The book concludes by highlighting key considerations needed to improve the scientific quality and interpretation of assessments. Detailed appendices include examples of population-level assessment approaches applicable to specific environmental management contexts, a modeling case study, and a supplemental r

Toxic chemicals can exert effects on all levels of the biological hierarchy, from cells to organs to organisms to populations to entire ecosystems. However, most risk assessment models express their results in terms of effects on individual organisms, without corresponding information on how populations, groups of species, or whole ecosystems may respond to chemical stressors. Ecological Modeling in Risk Assessment: Chemical Effects on Populations, Ecosystems, and Landscapes takes a new approach by compiling and evaluating models that can be used in assessing risk at the population, ecosystem, and landscape levels. The authors give an overview of the current process of ecological risk assessment for toxic chemicals and of how modeling of populations, ecosystems, and landscapes could improve the status quo. They present a classification of ecological models and explain the differences between population, ecosystem, landscape, and toxicity-extrapolation models. The authors describe the model evaluation process and define evaluation criteria. Finally, the results of the model evaluations are presented in a concise format with recommendations on modeling approaches to use now and develop further. The authors present and evaluate various models on the basis of their realism and complexity, prediction of relevant assessment endpoints, treatment of uncertainty, regulatory acceptance, resource efficiency, and other criteria. They provide models that will improve the ecological relevance of risk assessments and make data collection more cost-effective. Ecological Modeling in Risk Assessment serves as a reference for selecting and applying the best models when performing a risk assessment.

In spite of the growing importance of Species Sensitivity Distribution models (SSDs) in ecological risk assessments, the conceptual basis, strengths, and weaknesses of using them have not been comprehensively reviewed. This book fills that need. Written by a panel of international experts, Species Sensitivity Distributions in Ecotoxicology reviews

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

The definitive reference in its field, Ecological Risk Assessment, Second Edition details the latest advances in science and practice. In the fourteen years since the publication of the best-selling first edition, ecological risk assessment (ERA) has moved from the margins into the spotlight. It is now commonly applied to the regulation of c

Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants. This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species. The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments. - Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS) - Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay - Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess