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Professor Carroll Quigley presents crucial "keys" without which 20th century political, economic, and military events can never be fully understood. The reader will see that this applies to events past-present-and future. "The Rhodes Scholarships, established by the terms of Cecil Rhode's seventh will, are known to everyone. What is not so widely known is that Rhodes in five previous wills left his fortune to form a secret society, which was to devote itself to the preservation and expansion of the British Empire. And what does not seem to be known to anyone is that this secret society ... continues to exist to this day. ... This group is, as I shall show, one of the most important historical facts of the twentieth century." -Quigley

Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.