Harvard Public Health Magazine, Best Public Health Books and Journalism of 2022 The definitive social history of tuberculosis, from its origins as a haunting mystery to its modern reemergence that now threatens populations around the world. It killed novelist George Orwell, Eleanor Roosevelt, and millions of others – rich and poor. Desmond Tutu, Amitabh Bachchan, and Nelson Mandela survived it, just. For centuries, tuberculosis has ravaged cities and plagued the human body. In Phantom Plague, Vidya Krishnan, traces the history of tuberculosis from the slums of 19th-century New York to modern Mumbai. In a narrative spanning century, Krishnan shows how superstition and folk-remedies, made way for scientific understanding of TB, such that it was controlled and cured in the West. The cure was never available to black and brown nations. And the tuberculosis bacillus showed a remarkable ability to adapt – so that at the very moment it could have been extinguished as a threat to humanity, it found a way back, aided by authoritarian government, toxic kindness of philanthropists, science denialism and medical apartheid. Krishnan’s original reporting paints a granular portrait of the post-antibiotic era as a new, aggressive, drug resistant strain of TB takes over. Phantom Plague is an urgent, riveting and fascinating narrative that deftly exposes the weakest links in our battle against this ancient foe.

The definitive social history of tuberculosis, from its origins as a haunting mystery to its modern reemergence that now threatens populations around the world. It killed novelist George Orwell, Eleanor Roosevelt, and millions of others-rich and poor. Desmond Tutu, Amitabh Bachchan, and Nelson Mandela survived it, just. For centuries, tuberculosis has ravaged cities and plagued the human body. In Phantom Plague, Vidya Krishnan, traces the history of tuberculosis from the slums of 19th-century New York to modern Mumbai. In a narrative spanning century, Krishnan shows how superstition and folk-remedies, made way for scientific understanding of TB, such that it was controlled and cured in the West. The cure was never available to black and brown nations. And the tuberculosis bacillus showed a remarkable ability to adapt-so that at the very moment it could have been extinguished as a threat to humanity, it found a way back, aided by authoritarian government, toxic kindness of philanthropists, science denialism and medical apartheid. Krishnan's original reporting paints a granular portrait of the post-antibiotic era as a new, aggressive, drug resistant strain of TB takes over. Phantom Plague is an urgent, riveting and fascinating narrative that deftly exposes the weakest links in our battle against this ancient foe.

HAPPILY MARRIED for over a year and more in love than ever, Darcy and Elizabeth can’t imagine anything interrupting their bliss-filled days. Then an intense snowstorm strands a group of travelers at Pemberley, and terrifying accidents and mysterious deaths begin to plague the manor. Everyone seems convinced that it is the work of a phan-tom—a Shadow Man who is haunting the Darcy family’s grand estate. Darcy and Elizabeth believe the truth is much more menacing and that someone is trying to murder them. But Pem-berley is filled with family guests as well as the unexpected travelers—any one of whom could be the culprit—so unraveling the mystery of the murderer’s identity forces the newlyweds to trust each other’s strengths and work together. Written in the style of the era and including Austen’s romantic playfulness and sardonic humor, this suspense-packed sequel to Pride and Prejudice recasts Darcy and Elizabeth as a husband-and-wife detective team who must solve the mystery at Pemberley and catch the murderer—before it’s too late.

Consider two polar images of the same medical condition: the pale and fragile Camille ensconced on a chaise in a Victorian parlor, daintily coughing a small spot of blood onto her white lace pillow, and a wretched poor man in a Bowery flophouse spreading a dread and deadly infection. Now Katherine Ott chronicles how in one century a romantic, ambiguous affliction of the spirit was transformed into a disease that threatened public health and civic order. She persuasively argues that there was no constant identity to the disease over time, no "core" tuberculosis. What we understand today as pulmonary tuberculosis would have been largely unintelligible to a physician or patient in the late nineteenth century. Although medically the two terms described the same disease of the lungs, Ott shows that "tuberculosis" and "consumption" were diagnosed, defined, and treated distinctively by both lay and professional health workers. Ott traces the shift from the pre-industrial world of 1870, in which consumption was conceived of primarily as a middle-class malaise that conferred virtue, heightened spirituality, and gentility on the sufferer, to the post-industrial world of today, in which tuberculosis is viewed as a microscopic enemy, fought on an urban battleground and attacking primarily the outcast poor and AIDS patients. Ott's focus is the changing definition of the disease in different historical eras and environments. She explores its external trappings, from the symptoms doctors chose to notice (whether a pale complexion or a tubercle in a dish) to the significance of the economic and social circumstances of the patient. Emphasizing the material culture of disease--medical supplies, advertisements for faraway rest cures, outdoor sick porches, and invalid hammocks--Ott provides insight into people's understanding of illness and how to combat it. Fevered Lives underscores the shifting meanings of consumption/tuberculosis in an extraordinarily readable cultural history.

Infectious disease has the terrifying power to disrupt everyday life on a global scale, overwhelming public and private resources and bringing trade and transportation to a halt. In today's world, it's easier than ever to move people, animals, and materials around the planet, but the same advances that make modern infrastructure so efficient have made epidemics and even pandemics nearly inevitable. So what can -- and must -- we do in order to protect ourselves? Drawing on the latest medical science, case studies, and policy research, Deadliest enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease.--

"Few diseases have been more inextricably linked with our past than tuberculosis. The ancient Greeks called it phthisis or consumption, names still familiar in the early twentieth century. They knew that coughing up or spitting of blood were bad signs. Through the Medieval Period to the modern day, Helen Bynum explores the history and development of TB throughout the world, touching on the various discoveries that have emerged about the disease, and focusing on the clinical and experimental approaches of Rene Laennec (1781-1826) and Robert Koch (1842-1910). Therapies included miraculous touching, bleeding, travel, vaccines, sanatoria, open-air therapy, and surgery, although none proved successful. A real cure finally arrived after World War II, with anti-tuberculosis drugs, characterizing a new optimism about science, health, and society. Although concerns about TB faded away in the mid-twentieth century, the disease has now returned with a vengeance. Bynum describes the emerging picture from the World Health Organization of the difficulties in managing new drug-resistant forms of the disease that have established themselves in the developing world, and in poorer parts of large cities worldwide. The story of tuberculosis, it seems, is far from over."--

In 1950, a diagnosis of cancer was all but a death sentence. Mortality rates only got worse, and as late as 1986, an article in the New England Journal of Medicine lamented: "We are losing the war against cancer." Cancer is one of humankind's oldest and most persistent enemies; it has been called the existential disease. But we are now entering a new, and more positive, phase in this long campaign. While cancer has not been cured -- and a cure may elude us for a long time yet -- there has been a revolution in our understanding of its nature. Years of brilliant science have revealed how this individualistic disease seizes control of the foundations of life -- our genes -- and produces guerrilla cells that can attack and elude treatments. Armed with those insights, scientists have been developing more effective weapons and producing better outcomes for patients. Paul A. Marks, MD, has been a leader in these efforts to finally control this devastating disease. Marks helped establish the strategy for the "war on cancer" in 1971 as a researcher and member of President Nixon's cancer panel. As the president and chief executive officer for nineteen years at the world's pre-eminent cancer hospital, the Memorial Sloan-Kettering Cancer Center, he was instrumental in ending the years of futility. He also developed better therapies that promise a new era of cancer containment. Some cancers, like childhood leukemia and non-Hodgkin's lymphoma, that were once deadly conditions, are now survivable -- even curable. New steps in prevention and early diagnosis are giving patients even more hope. On the Cancer Frontier is Marks' account of the transformation in our understanding of cancer and why there is growing optimism in our ability to stop it.

A piercing and scientifically grounded look at the emergence of the coronavirus pandemic and how it will change the way we live—"excellent and timely." (The New Yorker) Apollo's Arrow offers a riveting account of the impact of the coronavirus pandemic as it swept through American society in 2020, and of how the recovery will unfold in the coming years. Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species. Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

Tuberculosis is an ancient disease, but it's not a disease of history. With more than a million victims every year - more than any other disease, including malaria - and antibiotic resistance now found in every country worldwide, tuberculosis is once again proving itself to be one of the smartest killers humanity has ever faced. But it's hardly surprising considering how long it's had to hone its skills. Forty-thousand years ago, our ancestors set off from the cradle of civilisation on their journey towards populating the planet. Tuberculosis hitched a lift and came with us, and it's been there ever since; waiting, watching, and learning. In The Robber of Youth, Kathryn Lougheed, a former TB research scientist, tells the story of how tuberculosis and humanity have grown up together, with each being shaped by the other in more ways than you could imagine. This relationship between man and microbe has spanned many millennia and has left its mark on both species. We can see evidence of its constant shadow in our genes; in the bones of the ancient dead; in art, music and literature. Tuberculosis has shaped societies -- and it continues to do so today.The organism responsible for TB, Mycobacterium tuberculosis, has had plenty of time to adapt to its chosen habitat - human lungs - and has learnt through natural selection to be an almost perfect pathogen. Using our own immune cells as a Trojan Horse to aid its spread, it's come up with clever ways to avoid being killed by antibiotics. But patience has been its biggest lesson -- the bacterium can enter into a latent state when times are tough, only to come back to life when a host's immune system can no longer put up a fight. Today, more than one million people die of the disease every year and around one-third of the world's population are believed to be infected. That's more than two billion people. Throw in the compounding problems of drug resistance, the HIV epidemic and poverty, and it's clear that tuberculosis remains one of the most serious problems in world medicine. The Robber of Youth follows the history of TB through the ages, from its time as an infection of hunter-gatherers to the first human villages, which set it up with everything it needed to become the monstrous disease it is today, through to the perils of industrialisation and urbanisation. It goes on to look at the latest research in fighting the disease, with stories of modern scientific research, interviews doctors on the frontline treating the disease, and the personal experiences of those affected by TB.